PharmSciRN: Excipients & Biomaterials (Sub-Topic)最新文献

{"title":"Superhydrophilic Coating Platform Supported Synergistic Antimicrobial Ability for Enhanced Wound Healing","authors":"Linhua Li, Yanan Wang, Bo Zhang, Yunbing Wang, Li Yang, Xiaorong Lan, Rifang Luo","doi":"10.2139/ssrn.3493849","DOIUrl":"https://doi.org/10.2139/ssrn.3493849","url":null,"abstract":"Nowadays, medical device infections constitute a major healthcare burden, particular administration of combating bacterial infections is of significance. In this work, robust mussel-inspired superhydrophilic coating was established, mainly based on the rapid polydopamine formation in the presence of sodium periodate. The stable superhydrophilicity was maintained due to the hydrophilic chemical components and nanoparticles-stacked surface topography. The superhydrophilicity allowed the coating to interfere with the protein adsorption effectively, and resulted in impressive antifouling performance. Moreover, due to the existence of aromatic catechol moieties, utilizing π-π stacking/hydrophobic interactions antibiotics (e.g. norfloxacin and cephalexin) were synchronously assembled into the superhydrophilic coating, respectively, endowing the surface with antibacterial ability. Interestingly, the embedded antibiotics presented meaningful sustained release with less than 15% released amount even after 30 days incubation, suggesting effective and safe antibacterial ability in a low dose-dependent manner, due to the antifouling supported 'release killing' of bacteria. The in vivo cutaneous wound healing evaluation further strongly demonstrated the synchronous effect of anti-infection and promoting wound healing. Such superhydrophilicity supported antifouling is also believed to open a new window for modifying biomedical devices with combined wound healing, antibacterial, and antifouling properties.","PeriodicalId":323490,"journal":{"name":"PharmSciRN: Excipients & Biomaterials (Sub-Topic)","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127361023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma Deposited Poly-Oxazoline Nanotextured Surfaces Dictate Osteoimmunomodulation Towards Ameliorative Osteogenesis","authors":"Zetao Chen, R. Visalakshan, Jia Guo, Fei Wei, Linjun Zhang, Lingling Chen, Zhengmei Lin, K. Vasilev, Yin Xiao","doi":"10.2139/ssrn.3368394","DOIUrl":"https://doi.org/10.2139/ssrn.3368394","url":null,"abstract":"Developing \"osteoimmune-smart\" bone substitute materials have become the forefront of research in bone regeneration. Biocompatible polymer coatings are applied widely to improve the bioactivity of bone substitute materials. In this context, polyoxazolines (Pox) have attracted substantial attention recently due to properties such as biocompatibility, stability, and low biofouling.In view of these useful properties, it is interesting to explore the capacity of Pox as an osteoimmunomodulatory agent to generate a favorable osteoimmune environment for osteogenesis. We applied a technique called plasma polymerization and succeeded in preparing Pox-like coatings (Ppox) and engineered their nanotopography at the nanoscale. We found that Ppox switched macrophages towards M2 extreme, thus inhibiting the release of inflammatory cytokines. The underlying mechanism may be related to the suppression of TLR pathway. The generated osteoimmune environment improved osteogenesis while inhibited osteoclastogenesis. This may be related to the release of osteogenic factors, especially Wnt10b from macrophages. The addition of nanotopography (16nm, 38nm, 68nm) can tune the Ppox-mediated inhibition on inflammation and osteoclastic activities, while no significant effects were observed within the tested nano sizes on the Ppox-mediated osteogenesis. These results collectively suggest that Ppox can be useful as an effective osteoiumunomodulatory agent to endow bone substitute materials with favourable osteoimmunomodulatory property. STATEMENT OF SIGNIFICANCE: In this study, we succeeded in preparing plasma deposited Pox-like nano-coatings (Ppox) via plasma polymerization and found that Ppox nanotopographies are useful osteoimmunomodulatory tools. Their osteoimmunodolatory effects and underlying mechanisms are unveiled. It is the first investigation into the feasibility of applying poly-oxazoline as an osteoimmunomodulatory agent. This expand the application of poly-oxazoline into the forefront in bone regeneration area for the development of advanced \"osteoimmune-smart\" bone substitute materials.","PeriodicalId":323490,"journal":{"name":"PharmSciRN: Excipients & Biomaterials (Sub-Topic)","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121850894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}