Fiyz最新文献

筛选

英文中文

Biochemical and pathological study of protective effect of Vitamin A in Azathioprine - induced hepatotoxicity in Rat 维生素A对硫唑嘌呤所致大鼠肝毒性保护作用的生化及病理研究

Fiyz Pub Date : 2009-04-01 DOI: 10.3923/JBS.2009.339.344

B. A. Tabrizi, D. Mohajeri, Yosef Doostar, Saed Baradaran Alizade, A. Khodadadi, Farzin Farajzade

{"title":"Biochemical and pathological study of protective effect of Vitamin A in Azathioprine - induced hepatotoxicity in Rat","authors":"B. A. Tabrizi, D. Mohajeri, Yosef Doostar, Saed Baradaran Alizade, A. Khodadadi, Farzin Farajzade","doi":"10.3923/JBS.2009.339.344","DOIUrl":"https://doi.org/10.3923/JBS.2009.339.344","url":null,"abstract":"Background: Azathioprine (AZA) is the most widely used immunosuppressive drug for preventing graft rejection and autoimmune disease. However, the therapeutic treatment induces several side effects such as toxicity to bone marrow, pancrease, liver and gastrointestinal tract. One of the major functions of Vitamin A is to act as a natural antioxidant by scavenging free radicals. Considering the kind of Azathioprine-induced damage in Liver tissue, we decided to study the protective effect of Vitamin A against Azathiprine-induced toxicity. Materials and Methods: Forty Male Wistar rats were divided into 4 groups (each group contains 10 rats). Group 1 was control group and only took normal saline. Groups 2 & 3 were administrated daily use of Vitamin A for 7 days I.M. and Group 4 was administrated with normal saline instead of Vitamin A in same condition as groups 2&3. In the last day groups 3 & 4 were administrated with single dose of AZA, 15 mg/kg (IP). After 24 hours, we took the animals blood and tissue samples and studied them for biochemical and pathological examinations. Results: This study showed that Azathioprine-induced damage on liver in group 3 is less than that in group 4 while the function of organ in group 3 is nearly the same as control group. Also vitamin A decreases Azathioprine-induced hepatotoxicity in rats. Conclusion: Regarding importance of Azathioprine-induced damage, the usage rate of this drug in medicine, and the results of this study, we suggest that co-administration of Azathioprine and vitamin E decreases the toxicity of this drug.","PeriodicalId":32133,"journal":{"name":"Fiyz","volume":"5 1","pages":"180-187"},"PeriodicalIF":0.0,"publicationDate":"2009-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76049405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

A comparison between the effect of oxytocin only and oxytocin plus propranolol on the labor: A double blind randomized trial 双盲随机对照试验:单纯使用催产素与催产素加心得安对产程的影响

Fiyz Pub Date : 2008-11-01 DOI: 10.1097/01.OGX.0000334692.42853.C2

M. Kashanian, Zahra Zarrin

{"title":"A comparison between the effect of oxytocin only and oxytocin plus propranolol on the labor: A double blind randomized trial","authors":"M. Kashanian, Zahra Zarrin","doi":"10.1097/01.OGX.0000334692.42853.C2","DOIUrl":"https://doi.org/10.1097/01.OGX.0000334692.42853.C2","url":null,"abstract":"Background: The purpose of the present study is the comparison between the effect of oxytocin alone or in combination with propranolol on the labor. Materials & Methods : A double blind randomized controlled trial was performed on 150 nuliparas with gestational age of 39-41 weeks of pregnancy and Bishop score of ≤5, singleton, and cephalic presentation. The patients were randomly assigned in two groups. In the first group (oxytocin group=75), oxytocin was started at the rate of 2 mIu/ml and increased to a dose of 2 mIu/ml every 15 minutes until desired contractions were obtained Then it was continued at this rate for 8 hours. If the patients entered the active phase of labor, induction would be continued until delivery otherwise, the induction would be discontinued and patients would be transferred to the pre-labor ward, and on the next day, the protocol was performed again, unless patients were entered the active phase and deliver, cesarean would be performed. In the second group (propranolol group=75 cases), before the beginning of oxytoicn, 2mg propranolol was slowly injected intravenously then the oxytocin was initiated similar to the previous group and, in the second day of induction, before beginning of oxytocin, a 2mg propranolol was injected intravenously again and inductions were performed completely like the other group. Results: There were no statistically significant difference between the two groups according to maternal and gestational age, primary Bishop score and neonatal birth weight. The number of patients who delivered at the first day did not show statistically significant difference between the two groups. [54 (72%) patients in Oxytocin group vs 62(82.6%) patients in propranolol group]. The mean duration for obtaining good contractions was shorter in propranolol group in the both first and second day of induction (2.59±0.87 h vs 3.7±2 h, p=0.000 for the first day and 1.8±1 h vs 3.9±0.89 h, p Conclusion: Propranolol may shorten the induction duration and labor and reduce the amount of necessary oxytocin.","PeriodicalId":32133,"journal":{"name":"Fiyz","volume":"147 1","pages":"7-11"},"PeriodicalIF":0.0,"publicationDate":"2008-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76549963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9