A. Kachmazov, L. Bolotina, A. Kornietskaya, Yu. B. Karagodina, I. Droshneva, A. Fedenko
{"title":"Novel approaches to treatment of locally advanced rectal cancer","authors":"A. Kachmazov, L. Bolotina, A. Kornietskaya, Yu. B. Karagodina, I. Droshneva, A. Fedenko","doi":"10.17650/2686-9594-2020-10-3-4-73-83","DOIUrl":"https://doi.org/10.17650/2686-9594-2020-10-3-4-73-83","url":null,"abstract":"Combination of neoadjuvant chemoradiotherapy with subsequent total mesorectum excision and 6-months of adjuvant chemotherapy remains a standard approach to treatment of locally advanced rectal cancer (T3 or T4 and / or N1–3; M0) for more than 15 years, which is reflected in practical guidelines of most leading oncological societies. However, recent data suggests possibilities of more individualized treatment conceptions with a potential of further improvement of long-term therapy outcomes and patient’s quality of life. In this paper we present review of results of clinical trials which investigated new approaches to treatment of locally advanced rectal cancer.","PeriodicalId":320537,"journal":{"name":"Pelvic Surgery and Oncology","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116959724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}