Serbian Journal of Dermatology and Venerology最新文献

{"title":"Perianal Allergic Contact Dermatitis from Benzocaine – a Case Report","authors":"Malena Gergovska, K. Semkova, J. Kazandjieva, N. Tsankov","doi":"10.2478/sjdv-2013-0016","DOIUrl":"https://doi.org/10.2478/sjdv-2013-0016","url":null,"abstract":"Abstract A large number of contact allergic reactions to benzocaine have been reported since its introduction to the pharmaceutical market as an active ingredient in different over-the-counter anesthetic ointments. Benzocaine is used as a key ingredient in many pharmaceuticals, such as products for oral ulcers, wound and burn preparations, sunburn remedies, hemorrhoidal preparations, oral and gingival products, sore throat sprays/lozenges, callous and wart remedies, creams for treatment of poison ivy dermatitis, tooth ache and denture irritation products. We present a 56-year-old Caucasian male with chronic rash, accompanied by intense itching in the perianal area. The lesions occurred two months earlier and the patient was treated with a wide range of topical antifungals, antibiotics and corticosteroids, with temporary improvement. The skin lesions were consistent with chronic allergic contact dermatitis. The patient denied using any topical preparations other than those prescribed by his dermatologist. Patch testing with the European baseline series was performed. A strongly positive reaction to benzocaine was identified on reading days 2 and 3. Targeted history showed intermittent use of benzocaine anti-hemorrhoidal cream to treat concomitant hemorrhoids. Benzocaine was discontinued and treatment with methylprednisolone aceponate 0.1% was initiated, resulting in significant improvement. No relapse was observed at 3-month follow-up. In conclusion, patients with confirmed benzocaine allergy should pay special attention to product labels and avoid products that contain benzocaine and its related substances. All products labelled as “anaesthetic” or “caine” should be suspected of containing benzocaine or related compounds. Patient education and awareness are critical to avoid further episodes and relapses. Sažetak Uvod. U svetskoj stručnoj literaturi opisan je veliki broj slučajeva kontaktne senzibilizacije izazvane lokalnom upotrebom benzokaina. Ovo se može objasniti velikim brojem lokalnih farmaceutika prisutnih na farmaceutskom tržištu koji se bez lekarskog recepta mogu nabaviti, a koji u svom sastavu sadrže lokalni anestetik. Benzokain predstavlja ključnu aktivnu supstanciju u mnogim preparatima koji se koriste za lečenje oralnih ulceracija, promena na desnima, bolnih upala zuba i grla, opekotina, rana, hemoroida. Nalazi se u velikom broju preparata za ispiranje usta, ali i lokalnih pripravka za lečenje kalusa i klavusa. Prikaz slučaja. Prikazujemo 56 godina staru pacijentkinju čija je glavna tegoba bila intenzivan svrab u perianalnom predelu. Dva meseca pre pregleda kod nas, pored osećaja svraba, na koži perianalne regije pojavilo se intenzivno crvenilo. U tom vremenskom periodu, u terapiju je uvođen veći broj različitih preparata za lokalno lečenje: antimikotici, antibiotici, kortikosteroidi. Poboljšanje je bilo privremeno, tako da su u momentu pregleda promene odgovarale kliničkoj slici kontaktnog dermatitisa. Pacijentkinja je negirala upot","PeriodicalId":302906,"journal":{"name":"Serbian Journal of Dermatology and Venerology","volume":"303 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121323418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extramammary Paget’s Disease in the Pubic Region: a Case Report","authors":"S. Stojanović, N. Vuckovic, P. Jeremić, Biljana Jeremić","doi":"10.2478/sjdv-2013-0014","DOIUrl":"https://doi.org/10.2478/sjdv-2013-0014","url":null,"abstract":"Abstract The authors present a case of a patient with extramammary Paget’s disease in the pubic region treated by a dermatologist with a private practice for almost 4 years before incisional biopsy was performed. A thorough examination showed no evidence of malignancies of internal organs, whereas definite diagnosis was made by excision of the entire skin lesion and histopathological analysis. With regard to multiple criteria, findings in our patient were consistent with current literature data, but interestingly, the primary extramammary Paget’s disease has not spread into deeper tissues. Sažetak Autori prikazuju slučaj bolesnice sa ekstramamarnom Padžetovom bolesti u pubičnoj regiji koja je lečena kod dermatologa u privatnoj praksi skoro dve godine pre incizione biopsije promene. Detaljnom pretragom nije utvrđeno istovremeno prisustvo maligniteta unutrašnjih organa, a definitivna dijagnoza je postavljena ekscizijom kožne promene u celosti i odgovarajućom patohistološkom analizom. Po mnogim kriterijumima naša bolesnica odgovara navodima u savremenoj literaturi, ali je u ovom slučaju bilo zanimljivo to da nije došlo do širenja neoplazme sa mesta primarnog ekstramamarnog M. Padžet u dubinu tkiva.","PeriodicalId":302906,"journal":{"name":"Serbian Journal of Dermatology and Venerology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129938953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cheilitis Glandularis Apostematosa in a Female Patient – a Case Report","authors":"M. Paravina","doi":"10.2478/sjdv-2013-0015","DOIUrl":"https://doi.org/10.2478/sjdv-2013-0015","url":null,"abstract":"Abstract Cheilitis is an inflammatory condition of the vermilion border of the lips, which is the junction between the skin and the mucosa. Cheilitis may arise as a primary disorder of the vermilion zone; the inflammation may extend from the nearby skin, or less often from the oral mucosa. Primary cheilitis lesions are either superficial or deep. Deep types include cheilitis glandularis (inflammatory changes and lip gland swelling), and granulomatous cheilitis (chronic swelling of the lip due to granulomatous inflammation mostly of unknown origin). Cheilitis glandularis is a rare condition that mostly affects the lower lip and it is characterized by nodular enlargement, reduced mobility and lip erosion. Based on clinical presentation, cheilitis glandularis may be classified into three subtypes: simplex (described as Puente and Acevedo), superficial suppurative (described by Baelz-Unna), and the most severe type - deep suppurative, also known as cheilitis glandularis apostematosa (Volkmann’s cheilitis) characterized by deep-seated inflammation forming abscesses and fistulous tracts. This is a case report of a female patient with a deep suppurative type of cheilitis affecting both lips. Treatment with systemic antibiotics (using antibiogram tests), corticosteroids and topical therapy resulted in significant improvement. Sažetak Heilitis (Cheilitis) inflamatorno je oboljenje rumene zone usana (vermiliona) koja se nalazi na prelazu kože u sluzokožu. Heilitisi koji nastaju kao samostalna oboljenja mogu biti površni ili duboki. Duboki su Cheilitis glandularis i Cheilitis granulomatosa. Cheilitis glandularis (CG) retka je bolest koja najčešće zahvata donju usnu i karakteriše je nodularno uvećanje, redukovani mobilitet i everzija usne. Kliničke varijante su CG simplex (Puente and Acevedo), CG suppurativa superficiallis (Baelz-Unna) i CG suppurativa profunda seu CG apostematosa (Von Volkmann). Mi prikazujemo bolesnicu sa dubokom supurativnom formom heilitisa na obema usnama, kod koje je sistemska primena antibiotika, prema antibiogramu, i kortikosteroida, uz lokalnu terapiju, dovela do znatnog poboljšanja.","PeriodicalId":302906,"journal":{"name":"Serbian Journal of Dermatology and Venerology","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115386861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Penile Nodules: a Case Series of Three Patients","authors":"M. Bjekić","doi":"10.2478/sjdv-2013-0013","DOIUrl":"https://doi.org/10.2478/sjdv-2013-0013","url":null,"abstract":"Abstract Artificial penile nodules are inert objects inserted beneath the skin of the penis. Objects placed underneath the skin of the penile shaft may include plastic beads made from toothbrushes, silicon, metal pellets, glass, ivory, precious metals, marbles or pearls. The penile bead implantation is performed largely due to the belief that it will enhance sexual performance and pleasure of female or male sexual partners during intercourse. In this article, three cases with artificial penile nodules made of toothbrushes and dice are presented. All three men have implanted foreign bodies underneath the dorsal aspect of the penile skin during their prison stay and implantations were not followed by any side effects. However, insertion of foreign bodies may be followed by early and late complications and transmission of blood-borne viruses. Penile implants are important for dermatological consideration, because they make condom use more difficult and may represent a risk factor for sexually transmitted infections. Sažetak Uvod: Arteficijelni penisni nodusi su inertni objekti koji se postavljaju ispod kože penisa u cilju povećanja seksualnog zadovoljstva kako osobe koja ih je implantirala, tako i njenih budućih seksualnih partnera. Objekti koji se postavljaju pod kožu su obično od plastike, silikona, metalnih loptica, stakla, drveta, mermera ili dragocenih metala. Prikaz sučaja: U radu su prikazana tri pacijenta koji su tokom boravka u zatvoru pod kožu dorzalne strane penisa sami implantirali strana tela koja su napravili od plastike držača četkica za zube i od kockice za jamb. Proces implantacije je prošao bez neželjenih efekata. Diskusija: Iako ni u jednom od tri prikazana slučaja nije bilo neželjenih efekata, poznato je da se posle intervencija ove vrste mogu razviti rane i kasne komplikacije. Takođe je poznato na osnovu sluačjeva objavljenih u svetskoj literaturi, da postoji povišeni rizik za prenošenje virusa hepatitisa i HIV-a tokom ove prakse. Pacijente prikazujemo sa ciljem da dermatovenerologe upoznamo sa ovom praksom koja je sve više prisutna i u našoj sredini, kao i sa problemima koje ona nosi, kao što je, između ostalog, otežana upotreba kondoma tokom seksualnih odnosa, što vlasnike implantata dovodi u povećani rizik za polno prenosive infekcije. Zaključak: Na osnovu podataka iz nama dostupne literature, tri slučaja opisana u ovom radu predstavljaju prve slučajeve arteficijalnih penisnih implantata u Srbiji","PeriodicalId":302906,"journal":{"name":"Serbian Journal of Dermatology and Venerology","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115324853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}