Biofunctional Materials最新文献

Non-fickian diffusion of small-molecule drugs from phase- separated dextran hydrogels through host-guest complexation 相分离右旋糖酐水凝胶中小分子药物通过主客体络合的非粘性扩散

Biofunctional Materials Pub Date : 2023-03-15 DOI: 10.55092/bm20230002

Ki Hyun Bae, S. Ng, Li Li, M. Kurisawa

引用次数: 0

Biofunctional materials - an interdisciplinary and open access journal 生物功能材料-一个跨学科和开放获取期刊

Biofunctional Materials Pub Date : 2023-03-15 DOI: 10.55092/bm20230001

Gurtej Singh, M. Rafailovich

引用次数: 0

Polymicellar-based drug delivery systems for use in nanodentistry 纳米牙医学中基于聚胶束的药物输送系统

Biofunctional Materials Pub Date : 2023-03-15 DOI: 10.55092/bm20230003

Z. Haidar

引用次数: 0

Cell interactions and osteogenic differentiation on marine sponge-derived scaffolds: a systematic review 海洋海绵支架的细胞相互作用和成骨分化:系统综述

Biofunctional Materials Pub Date : 2023-01-01 DOI: 10.55092/bm20230007

Jonas de Araújo Silva, Adriel Filipe Santos Braga da Silva, Amanda Sardeli Alqualo, Beatriz Viegas, Ana Cláudia Muniz Rennó, Renata Neves Granito

{"title":"Cell interactions and osteogenic differentiation on marine sponge-derived scaffolds: a systematic review","authors":"Jonas de Araújo Silva, Adriel Filipe Santos Braga da Silva, Amanda Sardeli Alqualo, Beatriz Viegas, Ana Cláudia Muniz Rennó, Renata Neves Granito","doi":"10.55092/bm20230007","DOIUrl":"https://doi.org/10.55092/bm20230007","url":null,"abstract":"Marine sponges, with their unique blend of organic and inorganic components, hold promise as biomaterials for bone tissue engineering. In this study, we systematically reviewed and comprehensively analysed in vitro assays evaluating osteogenic cell behaviour on scaffolds derived from marine sponges. Additionally, we investigated the potential of these scaffolds to induce cell differentiation and viability. Our analysis included 2,291 publications, with nine studies meeting the eligibility criteria for qualitative analysis. Results consistently showed strong adhesion of osteogenic cells to marine sponge-derived scaffolds facilitated by the interconnected porous structure. Cells exhibited elongated morphologies along scaffold fibres, indicative of a favourable growth environment. Comparative analyses demonstrated superior cell adhesion on marine sponge-derived scaffolds compared to other materials. Cell proliferation was observed across all studies, with a notable increase throughout the culture period. Marine sponge-derived scaffolds induced osteogenic differentiation, evidenced by osteocalcin and osteopontin expression. Notably, differences in cellular differentiation were attributed to diverse scaffold manufacturing methods. Our study highlighted the lack of standardised test procedures and the moderate risk of bias in the analysed studies, emphasising the need for further research with established protocols. Overall, this comprehensive analysis sheds light on osteogenic cell interactions with marine sponge-derived scaffolds, positioning them as promising biomaterials for bone tissue engineering. Understanding cellular responses to these scaffolds opens new possibilities for advanced research and regenerative medicine applications.","PeriodicalId":302178,"journal":{"name":"Biofunctional Materials","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136207308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bubaline tissues-based extracellular matrix scaffolds for tissue regeneration: current use and future prospectives 用于组织再生的基于丁醛组织的细胞外基质支架:目前的使用和未来的展望

Biofunctional Materials Pub Date : 2023-01-01 DOI: 10.55092/bm20230008

Naveen Kumar, Vineet Kumar, Anil Kumar Gangwar, Sonal Saxena, Pawan Diwan Singh Raghuvansi, Dayamon D. Mathew, Sameer Shrivastava, Ashwathy Gopinathan

引用次数: 0

Encapsulation of fibrinogen and thrombin with calcium carbonate for hemorrhage control 碳酸钙包封纤维蛋白原和凝血酶控制出血

Biofunctional Materials Pub Date : 1900-01-01 DOI: 10.55092/bm20230004

Henry T. Peng, M. Siddiqui

{"title":"Encapsulation of fibrinogen and thrombin with calcium carbonate for hemorrhage control","authors":"Henry T. Peng, M. Siddiqui","doi":"10.55092/bm20230004","DOIUrl":"https://doi.org/10.55092/bm20230004","url":null,"abstract":": Hemorrhage remains the major cause of death in combat and civilian trauma, although significant advances in hemostatic agents and blood products have enhanced damage control resuscitation and reduced mortality. Currently, few hemostats are available for cessation of non-compressible torso hemorrhage, e.g., intra-abdominal hemorrhage. To address this hard-to-solve problem, self-propelling hemostatic particles composed of coagulation factors e.g., fibrinogen, thrombin, CaCO 3 and protonated tranexamic acid (TXA + ) that can move against blood flow and promote clot formation have been developed. This paper describes the preparation and characterization of CaCO 3 - encapsulated fibrinogen/thrombin particles. The particles were prepared by interfacial reaction method using water-oil-water emulsion under different conditions that varied in the concentrations of the coagulation factor and ammonium carbonate solutions, amounts of surfactants, mixing speed, volume ratio between water and oil phases. The resulting CaCO 3 encapsulated fibrinogen/thrombin particles were characterized via light microscopy for morphology, gel electrophoresis for presence of fibrinogen and thrombin, rotational thromboelastometry for hemostatic effects and reaction with TXA + for self-propulsion test. It was found that CaCO 3 particles had spherical structure with less than 10 µm in diameter, could encapsulate fibrinogen and thrombin, enhance blood coagulation, and generate bubbles for propulsion by reacting with TXA + . Moreover, when particles were combined with TXA + , a synergistic hemostatic effect was obtained. These hemostatic and self-propelling properties could be optimized via changes to preparation method and composition. Further studies in animal bleeding models are warranted.","PeriodicalId":302178,"journal":{"name":"Biofunctional Materials","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130649128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FRET-based carbazole-fluorescein ionic nanoparticle for use as an effective bioimaging agent 基于fret的咔唑荧光素离子纳米粒子作为一种有效的生物显像剂

Biofunctional Materials Pub Date : 1900-01-01 DOI: 10.55092/bm20230006

Amanda Jalihal, Hannah Krehbiel, Samantha Macchi, Mavis Forson, Mujeebat Bashiru, Thuy Le, Caroline Kornelsen, Noureen Siraj

引用次数: 0

The effect of high salinity on the infectivity of H1N1 and SARS-COV-2 viruses 高盐度对H1N1和SARS-COV-2病毒传染性的影响

Biofunctional Materials Pub Date : 1900-01-01 DOI: 10.55092/bm20230005

Kuan-Che Feng, Jacob.F Myers, Kaitlyn Swayze, Fan Yang, Won-Il Lee, S. Mueller, A. Khan, Karin Hasegawa, M. Simon, K. Levon, Peng Zhang, Yuefan Deng, M. Rafailovich

引用次数: 1