American Journal of Medical and Biological Research最新文献

{"title":"Assessment of T2 Hyperintens Focies in Case of Occurrence of Arterial Hypertension and Type 2 Diabetes Mellitus Together and Separately","authors":"Guluzade L.Ch., Sultanova M.C, Gafarov I.A.","doi":"10.12691/ajmbr-11-1-1","DOIUrl":"https://doi.org/10.12691/ajmbr-11-1-1","url":null,"abstract":"","PeriodicalId":301254,"journal":{"name":"American Journal of Medical and Biological Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130323303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tenascin-C (TNC) Promotes Breast Cancer Cell Invasion and Proliferation: Functional Effects of TNC Knockdown in Highly Invasive Breast Cancer Cell Lines","authors":"Ali S Alharth, Musaad A Alsuliman, Abo Baker I Alshomrani, Waleed A Alyami","doi":"10.12691/ajmbr-9-1-4","DOIUrl":"https://doi.org/10.12691/ajmbr-9-1-4","url":null,"abstract":"","PeriodicalId":301254,"journal":{"name":"American Journal of Medical and Biological Research","volume":"216 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124265909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Key Predictors of Anemia in Under Five Children in Rural Setting of Bangladesh: A Cross Sectional Study","authors":"Md. Moniruzzaman Mollah, A. Mosaddik, As-Saba Hossain, S. Naznin, Andrew Asim Roy, Md. ShukurAli, P. Hassan, Md. Ashraful Islam","doi":"10.12691/ajmbr-9-1-3","DOIUrl":"https://doi.org/10.12691/ajmbr-9-1-3","url":null,"abstract":"Introduction: Anemia is a substantial public health problem that happens worldwide with higher prevalence noted in children less than 5 years and rural children. The studywas aimed to explore the keypredictors of anemia of study population in rural setting of Bangladesh. Methodology & Materials: This cross-sectional study was conducted in the rural Bangladesh from 1 July 2018 to December 2019. Under-five children aged six months to below sixty months were enrolled in the study. Data were collected through face-to-face interview from attending primary caregiver and from the results of laboratory tests of blood sample from target children. Data were analyzed through SPSS 23 software. Initially univariate analysis was done to identify predictors of anaemia followed by multivariate analysis to explore the key predictors through logistic regression. Results: A total data of258 under-five children aged 6-59 month were included in this study from the rural areas of Bangladesh. Among the studied children overall prevalence of anaemia was found 61.8%. The significant predictors (p <0.05) of anaemia through univariate analysis are age, maternal education level, monthly family income, exclusive breast feeding, proper complementary feeding practice as well as regular consumption of animal protein, fruits and vegetables. In addition, children who were under-weight stunted and wasted. Through multivariate analysis the key factors were explored as age group 6-24 month (AOR=0.02; p=0.006), family income less than 10000 BDT group-i.e 5000BDT or below (AOR=0.27;p=0.01) and 5001- 10000 BDT (AOR=8.84; 0.02), early and late weaning practiced children (AOR=0.23;p=0.002), low consumption of animal protein (AOR=0.05; p=0.001), and vegetables (AOR=0.18; p<0.001), stunting (AOR=0.18;p<0.001), wasting (AOR=0.14; p=0.03) and children who have chronic or recent infection (AOR=0.33; p=0.008). Conclusion: The keypredictors of anaemia are explored in this study are age below 2 year, family income less than 10000 BDT (in 2018 AD) or below, early and late weaning practice, low consumption of animal protein and vegetables, chronic malnutrition, acute malnutrition and chronic or recent infection. Rising mass awareness among the caregiver group on child care, nutrition and special focus to the children below age of two years will be the key strategies to prevent and control this extensive public health problem in Bangladesh.","PeriodicalId":301254,"journal":{"name":"American Journal of Medical and Biological Research","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125138187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Platelet-rich Plasma in Osteoarthritis of Knee-joint","authors":"Sheikh Forhad, Erfanul Huq Siddiqui, Md. Shamsul Alam, Anjumun Ara, Jannat Sultana","doi":"10.12691/AJMBR-9-1-1","DOIUrl":"https://doi.org/10.12691/AJMBR-9-1-1","url":null,"abstract":"","PeriodicalId":301254,"journal":{"name":"American Journal of Medical and Biological Research","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128512454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Atypical Expression of Retinoic Acid Inducible GATA6 Protein in Placenta is a Convenient Biomarker for Newborn Health Assessment","authors":"Abel Kangnidé, Denis Akpovo, C. D. Capo-chichi","doi":"10.12691/ajmbr-8-1-3","DOIUrl":"https://doi.org/10.12691/ajmbr-8-1-3","url":null,"abstract":"Background: Embryonic health assessment prior to delivery is not a priority in Africa due to the lack of efficient platforms for biomarker screening of defective heart or metabolic syndromes. Beside genetic mutations, some environmental, nutritional, or epigenetic events can induce abnormal protein expression impacting embryonic heart and gut developments. Among these proteins is the retinoic acid (vitamin A) inducible GATA6 which acts as transcription factor targeting the promoter of gene stimulated during placenta, embryonic heart and gut lineage specification. The objective of this study is to investigate GATA6 expression profile in placenta cells, to determine the impact of its abnormal expression on the newborn survival. Methods: Ethical approval of CER-ISBA) was obtained prior to placenta sample collection in the hospital obstetric service. Micro-fragments of placenta tissues (n=80) were collected after delivery and lysed for GATA6 analysis with immunoblot (western blot) method. Results: We observed two isoforms of GATA6 (long L and short S isoforms). All placenta lysates of living newborn expressed the type S isoform of GATA6 (n=76). In all 80 samples there is variable expression frequency for the type L isoform of GATA6. Normal expression of Type L isoform of GATA6 was observed in 63.8% of the samples; overexpression was observed in 7.5% of the samples; low expression was in 20% of them and totally lost in 8.7% of the samples. Retrospective analysis of 6 stillborn infant charts, linked 4 of them to deficient placental GATA6. Conclusion: Our preliminary data suggested that GATA6 could be used as biomarker for embryonic and newborn survival prognostic as well as for the postnatal screening of the risk to develop congenital heart diseases and metabolic syndromes during lifespan.","PeriodicalId":301254,"journal":{"name":"American Journal of Medical and Biological Research","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126994344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Alpha Lipoic Acid (ALA) on S. cerevisiae Cell Proliferation","authors":"Henna Purewal","doi":"10.12691/ajmbr-6-2-1","DOIUrl":"https://doi.org/10.12691/ajmbr-6-2-1","url":null,"abstract":"This experiment investigates what effect ALA may have on the growth of S. cerevisiae, based on extensive studies that have been conducted previously on the therapeutic capabilities of ALA (α-lipoic acid) in various cancers because of its potent antioxidant and apoptotic effects. It manages this because it serves a significant role in enzymatic processes crucial to energy production in cells. In energy metabolism, ALA is responsible for generating acetyl-CoA from pyruvate, and it thus plays a large role in the PDC (pyruvate dehydrogenase complex), an important link connecting glucose metabolism with the citric acid cycle [1]. It helps to shuttle carbon into aerobic respiration, specifically for converting pyruvate into acetyl-CoA and the formation of NADH and carbon dioxide. The process is regulated by enzymes called PDKs, which serve to catalyze suppression of the PDC when the cellular environment becomes nutrient-limited, or glucose scarce. PDKs are speculated to be able to inactivate the PDC via phosphorylation, thus preserving pyruvate for a different metabolic pathway. It is known that overexpression of PDKs blocks oxidative decarboxylation of pyruvate, so targeting the inhibition of PDKs could upregulate PDC activity [2]. Studies have revealed that PDC inhibition is associated with the mechanisms of many metabolic disorders, even cancer (Stacpoole, 2017). In S.cerevisiae cells, which are model organisms for cancer studies, energy is generated typically anaerobically through alcohol fermentation, until this is impacted and it switches to metabolism controlled by the citric acid cycle. This slows down cell proliferation, so it is predicted that as ALA concentrations are increased, cell proliferation will decrease, as indicated by an average cell count of each culture. After experimentation, results revealed that each ALA concentration, 0.125% (2.37×10-20), 0.25% (1.49×10-16), 0.5% (6.41×10-16), and 1% (9.36×10-18), significantly reduced the cell count of their respective cell culture, as compared to the control of 0% ALA. Also, alcohol test strips revealed that with higher concentrations, the cells switched to aerobic respiration as no alcohol was being produced, so fermentation was stopped. This supports the hypothesis that increasing concentrations of ALA will lead to a decrease in cell proliferation, and may indicate that ALA upregulates PDC activity via inhibition of PDKs, which makes it a potential candidate in adjuvant therapies for cancer treatment.","PeriodicalId":301254,"journal":{"name":"American Journal of Medical and Biological Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124401115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}