Sterilisation of Tissues Using Ionising Radiations最新文献

筛选
英文 中文
VIRAL INFECTIONS TRANSMITTED THROUGH TISSUE TRANSPLANTATION 通过组织移植传播的病毒感染
Sterilisation of Tissues Using Ionising Radiations Pub Date : 2005-12-31 DOI: 10.1533/9781845690779.4.255
T. Eastlund
{"title":"VIRAL INFECTIONS TRANSMITTED THROUGH TISSUE TRANSPLANTATION","authors":"T. Eastlund","doi":"10.1533/9781845690779.4.255","DOIUrl":"https://doi.org/10.1533/9781845690779.4.255","url":null,"abstract":"\u0000 ABSTRACT\u0000 \u0000 \u0000 The incidence of tissue allograft-transmitted infection is unknown and can best be inferred from prospective studies – that have not yet been performed and reported. Viral infections have been transmitted via tissue allografts such as bone, skin, cornea, and heart valves. Bone allografts have transmitted hepatitis C, human immunodeficiency virus (HIV-1), and human T-cell leukaemia virus. Corneas have transmitted rabies, hepatitis B virus, cytomegalovirus (CMV), and herpes simplex virus. Heart valves have been implicated in transmitting hepatitis B. HIV-1 and CMV have been transmitted by skin allografts. Use of comprehensive donor eligibility criteria; excluding potential donors with behaviours risky for HIV-1 and hepatitis infection, and donor blood testing have greatly reduced the risk. Recent reports of HIV transmitted from a seronegative donors prompts the addition of viral nucleic acid testing of the donor. During tissue processing, many allografts are exposed to disinfectants and sterilisation steps such as gamma irradiation, which further reduce or remove the risk of transmitted disease. Some viruses are fairly resistant to gamma irradiation and the high doses needed may be harmful to the tissue allografts. Because the effectiveness of some tissue grafts depends on cellular viability, not all can be subjected to sterilisation steps, and, therefore, the risk of infectious disease transmission remains. For these, preventing the transmission of viral infection relies mostly on careful donor selection and viral testing, but processing with mild disinfectant can be useful. To further assure safety in the use of allografts, the physician and hospital should select tissue banks that follow national professional standards as their source for allografts.\u0000 \u0000","PeriodicalId":301097,"journal":{"name":"Sterilisation of Tissues Using Ionising Radiations","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128545428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信