{"title":"Melkersson-Rosenthal syndrome associated to Hashimoto's thyroiditis","authors":"S. Bouomrani, Ines Lamloum, Rim Mesfar","doi":"10.53986/IBJM.2020.0020","DOIUrl":"https://doi.org/10.53986/IBJM.2020.0020","url":null,"abstract":"Melkersson-Rosenthal syndrome (MRS) is a rare neuromucocutaneous granulomatous disorder classically defined by the triad: fissured tongue (lingua plicata), recurrent orofacial edema, and relapsing facial paralysis. Association with other dysimmune disorders was reported suggesting an immunological origin to this syndrome. The association with autoimmune thyroiditis remains exceptional and unusual. We report the original case of an MRS associated with Hashimoto autoimmune thyroiditis in a 39-year-old Tunisian man with favorable outcome under thyroxine and systemic glucosteroids. A dosage of thyroid hormones and a screening for anti-thyroid antibodies would be useful in patients with an MRS.","PeriodicalId":300001,"journal":{"name":"Clinical Sciences Research and Reports","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131889629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Angoules, A. Christakou, H. Tsibidakis, Georgios A Angoules, S. Kapetanakis
{"title":"Horse–related spine and spinal cord injuries","authors":"A. Angoules, A. Christakou, H. Tsibidakis, Georgios A Angoules, S. Kapetanakis","doi":"10.15761/csrr.1000122","DOIUrl":"https://doi.org/10.15761/csrr.1000122","url":null,"abstract":"Horse-related athletic, recreational and professional activities is a worldwide widespread practice involving people of all ages. This kind of activity, due to the particular risks involved, is associated with a significant number of accidents and injuries of the musculoskeletal system. Spine injuries (SI) and spinal cord injuries (SCI) are serious injuries that can have devastating consequences for the rider. In the present review, we examined their epidemiology, their characteristics in terms of the mechanism and type of injury, the neurological damage they cause and the injured region of the spine. The type of the therapeutic approach and its results were also analyzed. 19 papers that included 7.569 patients, 632 (8.3%) of whom suffered spine or spinal cord injuries, were analyzed. A total of 1.072 injuries were analyzed, 56 % of which concerned men and 44% women. The fall from a horse is considered to be the main mechanism that causes injuries associated with fractures of the thoracic and lumbar spine. 58% of the patients with such injuries were hospitalized. There was a complete neurological damage in 31.8% of the patients, while in a significant proportion of 53.5% of the patients; quadriplegia was caused by the injury. Although conservative treatment in simple cases without neurological damage appears to be an effective therapeutic approach, in cases of unstable injuries and neurological impairment surgical treatment can be a method of choice with satisfactory results such as better mobilization and quality of life. *Correspondence to: Antonios G Angoules, Orthopaedic Department, Athens Medical Center, Athens, Greece, Tel: +30 6977011617, E-mail: antoniosangoules@yahoo.com","PeriodicalId":300001,"journal":{"name":"Clinical Sciences Research and Reports","volume":"27 6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123584524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sayeedul Al-amin, K. F. Salahin, T. Husain, T. Abir, K. Agho
{"title":"Analysing the prevailing status of nurses at private hospitals in Bangladesh: A study on quality of work life","authors":"Sayeedul Al-amin, K. F. Salahin, T. Husain, T. Abir, K. Agho","doi":"10.15761/csrr.1000121","DOIUrl":"https://doi.org/10.15761/csrr.1000121","url":null,"abstract":"Enhancing the quality of the work of employees and the overall productivity of an organization are considered the basic premises of Quality of Work Life (QWL). The purpose of this study is to examine the prevailing status of the level of QWL of Nurses at private hospitals in Bangladesh, to identify the critical factors influencing the QWL, and to suggest some strategies to improve the QWL. This study follows a mixed method approach to collect and analyze the data. This study reveals in terms of QWL of Nurses at private hospitals in Bangladesh that the nurses are suffering from considerable discrepancies in the working environment, job security, payment structure, promotion policy, overtime and shifting, and pressure on the job. Based on the findings, this study suggests some strategies for the concerned authorities to mitigate the sufferings of the nurses at private hospitals and ensure the QWL on it. *Correspondence to: Kingsley Emwinyore Agho, Department of Biostatistics, School of Science and Health, Western Sydney University, Australia, E-mail: K.Agho@westernsydney.edu.au","PeriodicalId":300001,"journal":{"name":"Clinical Sciences Research and Reports","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122318947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Factors effecting frequency of occurrence of back pain syndromes","authors":"Jerzy E. Kiwerski","doi":"10.15761/csrr.1000123","DOIUrl":"https://doi.org/10.15761/csrr.1000123","url":null,"abstract":"Low back pain syndromes are in the group of the commonest diseases observed in recent years and bear serious medical, social and economical burden. According to European data more than 70% of population suffered from back pain at least for a week in the lifetime, and 15-40% of population experiences low back pain every year. There is alarming decrease in the age of first onset described by many authors. Peak morbidity is observed in persons aged between 35 and 55 years, but a recent Japanese study brings evidence that 66.7% of middle-school children has already experienced low back pain lasting for at least 1 week, and relapse rate exceeds 60%. Increase of incidence and morbidity of low back pain is linked to lifestyle alterations including significant limitation of physical activities since young age, changes of hobby preferences, alteration of work habits favoring activities performed in improper body position lasting for hours or even years, to dynamic physical work. Pain may be presented in any phase of spinal overload syndromes. Back pain may result from nocyceptive activation in spinal, paraspinal tissues as well as irritating of nervous structures within vertebral canal, when appears as a neuropathic pain. Pain in spondylolisthesis may be related to ligamentous constrain, particularly when posterior longitudinal ligament (densely supplied with nocyceptive endings) is involved. The paper describes the commonest back pain syndromes and spinal deformities resulting from long-lasting overload with their typical presentation.","PeriodicalId":300001,"journal":{"name":"Clinical Sciences Research and Reports","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127318871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abigail J. Manning, E. Mahdi, A. Pepper, C. Pepper, N. Al-Musayeib, J. Mahdi
{"title":"Hydroxybenzoate magnesium analogues induced apoptosis in HT-1080 human fibrosarcoma cells","authors":"Abigail J. Manning, E. Mahdi, A. Pepper, C. Pepper, N. Al-Musayeib, J. Mahdi","doi":"10.15761/csrr.1000124","DOIUrl":"https://doi.org/10.15761/csrr.1000124","url":null,"abstract":"Acetylsalicylic acid, or aspirin, is one of the most common non-steroidal anti-inflammatory drugs, which has been shown to have anti-cancer effects. However, high doses are needed making it unsuitable as an oncology agent. We have previously reported increased potency in a series of hydroxybenzoate zinc (HBZn) aspirin analogues. Here we show that 3-hydroxybenzoate magnesium (3-HBMg) and 4-hydroxybenzoate magnesium (4-HBMg) aspirin derivatives showed cytotoxic effects at doses as low as 1mM. At these concentrations, 3-HBMg and 4-HBMg aspirin increased the level of caspase-3, p53, Bax and decreased the expression of the anti-antiapoptotic protein, Bcl-2, in HT-1080 Human fibrosarcoma cells. *Correspondence to: Jassem G Mahdi, Cardiff School of Medicine, Cochrane Medical Education Centre, Heath Park, UK, E-mail: mahdij2@cardiff.ac.uk","PeriodicalId":300001,"journal":{"name":"Clinical Sciences Research and Reports","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128722690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Malnutrition among Indian Children","authors":"Cyril Kanmony","doi":"10.15761/CSRR.1000128","DOIUrl":"https://doi.org/10.15761/CSRR.1000128","url":null,"abstract":"To have a sustainable and steady economic development in an economy it is a prerequisite that its children should be healthy, educated and trained. Many children in India are illiterates and unskilled and the problem of malnutrition is rampant. It is still having the largest number of malnourished children in the world [1]. In absolute number, it is 26 million [2]. On the basis of data available in 2015, the rate of stunting was 38.7% and wasting 15.1%. The overall rank of India in the Global Hunger Index (GHI) 2015 was 93 with a score of 31.1 [3]. It is also reported that in India, the per capita disease burden due to child and maternal malnutrition is 12 times higher than that is in China [4]. Even in 2019, the rate of stunting stands at 37.9% and wasted is close to 21%. India’s rank in the Global Hunger Index 2019 is 102 out of 117 countries taken for comparison with a score of 30.3. It is sad to note that even Sri Lanka (66), Nepal (73), Bangladesh (88) and Pakistan (94) are in better positions in nutrition standard than India [5-7]. While the rate of stunting decreased from 42% in 2010 to 37.9% in 2019, (54.2% in 2000) the rate of wasting increased from 17.1% in 19982002 [7] to almost 21% in 2019 (GHI 2019). Every year India adds seven million potentially wasted and stunted children to its population.","PeriodicalId":300001,"journal":{"name":"Clinical Sciences Research and Reports","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134104044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}