Hepatocellular Carcinoma - Challenges and Opportunities of a Multidisciplinary Approach [Working Title]最新文献

Surgical Therapy of Hepatocellular Carcinoma: State of the Art Liver Resection 肝细胞癌的外科治疗:肝切除术的现状

Hepatocellular Carcinoma - Challenges and Opportunities of a Multidisciplinary Approach [Working Title] Pub Date : 2021-10-25 DOI: 10.5772/intechopen.100231

S. Davakis, M. Vailas, Alexandros Kozadinos, P. Sakarellos, A. Karampa, D. Korkolis, G. Glantzounis, Alexandros Papalampros, E. Felekouras

{"title":"Surgical Therapy of Hepatocellular Carcinoma: State of the Art Liver Resection","authors":"S. Davakis, M. Vailas, Alexandros Kozadinos, P. Sakarellos, A. Karampa, D. Korkolis, G. Glantzounis, Alexandros Papalampros, E. Felekouras","doi":"10.5772/intechopen.100231","DOIUrl":"https://doi.org/10.5772/intechopen.100231","url":null,"abstract":"Hepatocellular carcinoma (HCC) represents the third most common cause of cancer-related death, showing incremental growth rates throughout the last decades. HCC requires multidisciplinary approach in a group of patients suffering from underlying chronic liver disease, usually in the setting of cirrhosis. The mainstay of treatment in resectable cases is surgery, with anatomic and non-anatomic liver resections widely implemented, as well as liver transplantation in well-selected individuals. Nowadays, there is a variety of liver parenchyma transection devices used by hepatobiliary surgeons in specialized centers, which has significantly improved postoperative outcomes in HCC patients. Therefore, hepatectomy is considered safe and feasible and should be the main therapeutic option for HCC patients, candidates for resection. Liver resection utilizing cavitron ultrasonic aspirator in combination with bipolar radiofrequency ablation is safe and effective for the treatment of HCC with favorable clinical and oncological outcomes.","PeriodicalId":298586,"journal":{"name":"Hepatocellular Carcinoma - Challenges and Opportunities of a Multidisciplinary Approach [Working Title]","volume":"129 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116333151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Minimally Invasive Surgery for Hepatocellular Carcinoma; Latest Advances 肝细胞癌的微创手术治疗最新进展

Hepatocellular Carcinoma - Challenges and Opportunities of a Multidisciplinary Approach [Working Title] Pub Date : 2021-10-04 DOI: 10.5772/intechopen.99840

A. Giakoustidis, A. Koffas, D. Giakoustidis, Vasileios N. Papadopoulos

引用次数: 0

Systemic Therapy in Hepatocellular Carcinoma 肝细胞癌的全身治疗

Hepatocellular Carcinoma - Challenges and Opportunities of a Multidisciplinary Approach [Working Title] Pub Date : 2021-09-20 DOI: 10.5772/intechopen.100257

charonpongsuntorn Charonpongsuntorn

引用次数: 0

Hepatitis B Virus (HBV) - Induced Hepatocarcinogenesis, a Founding Framework of Cancer Evolution & Development (Cancer Evo-Dev) 乙型肝炎病毒(HBV)诱导的肝癌发生，癌症进化与发展的基础框架(Cancer Evo-Dev)

Hepatocellular Carcinoma - Challenges and Opportunities of a Multidisciplinary Approach [Working Title] Pub Date : 2021-09-09 DOI: 10.5772/intechopen.99838

Wenbin Liu, Guangwen Cao

{"title":"Hepatitis B Virus (HBV) - Induced Hepatocarcinogenesis, a Founding Framework of Cancer Evolution & Development (Cancer Evo-Dev)","authors":"Wenbin Liu, Guangwen Cao","doi":"10.5772/intechopen.99838","DOIUrl":"https://doi.org/10.5772/intechopen.99838","url":null,"abstract":"In this chapter, we present the founding framework of a novel theory termed as Cancer Evolution-Development (Cancer Evo-Dev), based on the current understanding of hepatitis B virus (HBV) induced hepatocarcinogenesis. The interactions of genetic predispositions and HBV infection is responsible for the maintenance of chronic non-resolving inflammation. Under the inflammatory microenvironment, pro-inflammatory factors trans-activate the expression of cytidine deaminases and suppress the expression of uracil DNA glycosylase. The imbalance between the mutagenic forces and mutation-correcting forces facilitates the generations of somatic mutations, viral mutations, and viral integrations into the host genomes. The majority of cells with genomic mutations and mutated viruses are eliminated in survival competition. Only a small percentage of the mutated cells adapted to the hostile environment can survive, retro-differentiate, and function as cancer-initiating cells, representing a process of “mutation-selection-adaptation”. Cancer Evo-Dev lays the theoretical foundation for understanding the mechanisms by which chronic infection of HBV promotes hepatocarcinogenesis. This theory also plays an important role in specific prophylaxis, prediction, early diagnosis, and targeted treatment of cancers.","PeriodicalId":298586,"journal":{"name":"Hepatocellular Carcinoma - Challenges and Opportunities of a Multidisciplinary Approach [Working Title]","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114869699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Classification of Hepatocellular Carcinoma Using Machine Learning 使用机器学习的肝细胞癌分类

Hepatocellular Carcinoma - Challenges and Opportunities of a Multidisciplinary Approach [Working Title] Pub Date : 2021-09-07 DOI: 10.5772/intechopen.99841

Lekshmi Kalinathan, Deepika Sivasankaran, Janet Reshma Jeyasingh, Amritha Sennappa Sudharsan, Hareni Marimuthu

引用次数: 0

Hepatocellular Carcinoma: Diagnosis and Surveillance 肝细胞癌:诊断和监测

Hepatocellular Carcinoma - Challenges and Opportunities of a Multidisciplinary Approach [Working Title] Pub Date : 2021-09-05 DOI: 10.5772/intechopen.99839

A. Kale

{"title":"Hepatocellular Carcinoma: Diagnosis and Surveillance","authors":"A. Kale","doi":"10.5772/intechopen.99839","DOIUrl":"https://doi.org/10.5772/intechopen.99839","url":null,"abstract":"Hepatocellular carcinoma arises commonly on the background of liver cirrhosis. Patients presenting with clinical symptoms have advanced stage and often are unsuitable for curative therapies. Diagnosis of hepatocellular carcinoma is commonly performed by multiphase computed tomography (CT) and / or magnetic resonance imag¬ing scans (MRI). Contrast enhanced ultrasound and MRI with hepatobiliary contrast agents are better in characterizing small lesions. Tumor markers play an adjunct role in diagnosis. For HCC in cirrhotic liver biopsy is seldom required and diagnosis is based on typical imaging features of non-rim arterial phase hyperenhancement and washout on delayed phase and pseudocapsule appearance. This is due to differential blood supply of liver parenchyma, regenerative nodules and tumor. Biopsy is only required in noncirrhotic liver, vascular liver diseases, atypical imaging features. Surveillance programs involving high risk groups can help in early detection of lesions which are amenable for curative therapies. Biannual ultrasound with or without alfa fetoprotein are commonly used surveillance tests. Multidisciplinary teams provide platform for care coordination, reassessments of clinical course, and fine changes in treatment plans required for management of this complex group of patients.","PeriodicalId":298586,"journal":{"name":"Hepatocellular Carcinoma - Challenges and Opportunities of a Multidisciplinary Approach [Working Title]","volume":"AES-3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126495047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment of Advanced Hepatocellular Carcinoma 晚期肝细胞癌的治疗

Hepatocellular Carcinoma - Challenges and Opportunities of a Multidisciplinary Approach [Working Title] Pub Date : 2021-08-30 DOI: 10.5772/intechopen.99837

M. Aryan, Ellery Altshuler, Xia Qian, Wei Zhang

{"title":"Treatment of Advanced Hepatocellular Carcinoma","authors":"M. Aryan, Ellery Altshuler, Xia Qian, Wei Zhang","doi":"10.5772/intechopen.99837","DOIUrl":"https://doi.org/10.5772/intechopen.99837","url":null,"abstract":"Hepatocellular Carcinoma (HCC) is the fifth most common cancer and represents the fourth most common cause of cancer related death worldwide. Treatment of HCC is dictated based upon cancer stage, with the most universally accepted staging system being the Barcelona Clinic Liver Cancer (BCLC) staging system. This system takes into account tumor burden, active liver function, and patient performance status. BCLC stage C HCC is deemed advanced disease, which is often characterized by preserved liver function (Child-Pugh A or B) with potential portal invasion, extrahepatic spread, cancer related symptoms, or decreased performance status. Sorafenib has been the standard treatment for advanced HCC over the past decade; however, its use is limited by low response rates, decreased tolerance, and limited survival benefit. Researchers and clinicians have been investigating effective treatment modalities for HCC over the past several years with a focus on systemic regimens, locoregional therapy, and invasive approaches. In this systemic review, we discuss the management of advanced HCC as well as the ongoing research on various treatment opportunities for these patients.","PeriodicalId":298586,"journal":{"name":"Hepatocellular Carcinoma - Challenges and Opportunities of a Multidisciplinary Approach [Working Title]","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114488402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multimodal Imaging of Hepatocellular Carcinoma Using Dynamic Liver Phantom 肝细胞癌的动态肝影多模态成像

Hepatocellular Carcinoma - Challenges and Opportunities of a Multidisciplinary Approach [Working Title] Pub Date : 2021-08-26 DOI: 10.5772/intechopen.99861

Muntaser S. Ahmad, Osama Makhamrah, M. Hjouj

引用次数: 4

Research Frontier of Accurate Diagnosis and Treatment Guided by Molecular Typing of Hepatocellular Carcinoma 肝细胞癌分子分型指导下准确诊治的研究前沿

Hepatocellular Carcinoma - Challenges and Opportunities of a Multidisciplinary Approach [Working Title] Pub Date : 2021-08-23 DOI: 10.5772/intechopen.99836

Haicaho Zhao, Changzhou Chen, Jiefeng He

{"title":"Research Frontier of Accurate Diagnosis and Treatment Guided by Molecular Typing of Hepatocellular Carcinoma","authors":"Haicaho Zhao, Changzhou Chen, Jiefeng He","doi":"10.5772/intechopen.99836","DOIUrl":"https://doi.org/10.5772/intechopen.99836","url":null,"abstract":"Liver cancer will continue to be a major disease threatening the lives and health of our people in the next few decades. In recent years, with the development of early diagnosis and treatment of liver cancer, precise liver resection, and the development of targeted and immunotherapeutic drugs, the survival rate of liver cancer patients has been improved. Nevertheless, due to the high heterogeneity of liver cancer, patients with liver cancer in the same clinical stage still have great differences in response to treatment and prognosis. New staging and classification indicators are urgently needed to facilitate accurate diagnosis and treatment of liver cancer, so as to further improve the survival rate of patients. The continuous progress and development of multi-omics technology, single-cell technology, tumor molecular visualization technology and medical artificial intelligence, etc., make the molecular classification of liver cancer more and more approaching the true nature of tumor biological characteristics, thus contributing to the accurate diagnosis and treatment of liver cancer.","PeriodicalId":298586,"journal":{"name":"Hepatocellular Carcinoma - Challenges and Opportunities of a Multidisciplinary Approach [Working Title]","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132944655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0