Ophthalmologie最新文献

筛选

英文中文

[Corneal epithelial thickness in keratoconus patients compared to healthy controls]. [圆锥角膜患者角膜上皮厚度与健康对照的比较]。

IF 0.6 4区医学

Ophthalmologie Pub Date : 2022-09-01 Epub Date: 2022-04-01 DOI: 10.1007/s00347-022-01606-6

Larissa Lahme, Jens Julian Storp, Raphael Diener, Nicole Eter, Uwe Hansen, Martin Dominik Leclaire, Maged Alnawaiseh

{"title":"[Corneal epithelial thickness in keratoconus patients compared to healthy controls].","authors":"Larissa Lahme, Jens Julian Storp, Raphael Diener, Nicole Eter, Uwe Hansen, Martin Dominik Leclaire, Maged Alnawaiseh","doi":"10.1007/s00347-022-01606-6","DOIUrl":"10.1007/s00347-022-01606-6","url":null,"abstract":"Background: In keratoconus (KC) a progressive deformation and thinning of the cornea occurs. In contrast to Scheimpflug-based examinations, optical coherence tomography (OCT) can precisely measure the corneal layers separately, allowing separate analyses of corneal epithelial and corneal stromal thicknesses.Aim of this work: The aim of this work was to analyze the corneal epithelial thickness measured by optical coherence tomography (OCT) in patients with KC in comparison to the corneal epithelial thickness in healthy subjects. The diagnostic value of the observed changes was evaluated.Material and methods: In a retrospective analysis 125 eyes of patients with KC and 140 eyes of healthy subjects were included. Corneal measurements were performed by OCT (Optovue, XR-Avanti, Fremont, CA, USA). Corneal stromal thicknesses and corneal epithelial thicknesses in different locations were measured and analyzed.Results: There were significant differences in stromal and epithelial thickness measurements. Of the derived epithelial thickness parameters four showed a good discriminatory power between healthy controls and KC patients (area under the curve in the receiver operating characteristic analysis > 0.7).Conclusion: Patients with KC showed an altered epithelial thickness compared to healthy controls. The derived calculated parameters based on corneal epithelial thickness can distinguish between KC and a healthy cornea.","PeriodicalId":29790,"journal":{"name":"Ophthalmologie","volume":"119 1","pages":"952-957"},"PeriodicalIF":0.6,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51805380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Erratum to: Epigenetic changes in the promoter of the fragile histidine triad (FHIT) gene in human sebocytes under the influence of in vitro culture]. [在体外培养的影响下，人皮脂细胞中脆弱组氨酸三联体(FHIT)基因启动子的表观遗传变化]。

IF 0.9 4区医学

Ophthalmologie Pub Date : 2022-04-11 DOI: 10.1007/s00347-022-01627-1

Magdalena Jotzo, C. Zouboulis, W. Ballhausen

引用次数: 1