Current Trends in Toxicology and Pharmacology Research最新文献

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Efficacy of Botulinum Toxin Stereotype A and Its Relevant Mechanisms of Action in Both Cosmetic and Therapeutic Uses A型肉毒毒素在美容和治疗中的功效及其相关作用机制

Current Trends in Toxicology and Pharmacology Research Pub Date : 1900-01-01 DOI: 10.53902/cttpr.2021.01.000503

O. Tulp

引用次数: 0

Treatment with α-Methylparatyrosine Inhibits Sympathetic but Not Thyroidal Responses to Diet-Induced Thermogenesis in Lean Cafeteria-Overfed Rats α-甲基副酪氨酸治疗可抑制饮食诱导的产热大鼠的交感神经反应而非甲状腺反应

Current Trends in Toxicology and Pharmacology Research Pub Date : 1900-01-01 DOI: 10.53902/cttpr.2022.02.000504

O. Tulp

{"title":"Treatment with α-Methylparatyrosine Inhibits Sympathetic but Not Thyroidal Responses to Diet-Induced Thermogenesis in Lean Cafeteria-Overfed Rats","authors":"O. Tulp","doi":"10.53902/cttpr.2022.02.000504","DOIUrl":"https://doi.org/10.53902/cttpr.2022.02.000504","url":null,"abstract":"The sympathoplegic drug α-methylparatyrosine (α-MPT) was administered to lean, normally fed rats or rats overfed to induce diet induced thermogenesis (DIT) with a highly palatable Cafeteria diet regimen (Café) for twelve weeks, and measures of resting thermogenesis under thermoneutral conditions (VO2 at ambient 30°C), serum T3 and 24-hour urinary vanilmandelic acid (VMA) excretion determined before and after the α-MPT treatment. The café diet resulted in significant increases in VO2, serum T3, and VMA excretion. The α-MPT resulted in approximately fifty percent decrease in the Café-induced increase in VO2 after 24hours, while thyroidal function appeared clinically unaffected. These observations suggest that the sympathetic contributions to diet-induced thermogenesis (DIT) following chronic overfeeding with the Café diet regimen represent only about half of the reported dietary induced thermic response to overfeeding and non-sympathetic contributions including the thyroidal actions that likely account for the remaining proportion of the increased DIT and sympathetic component may decrease further over time spent since feeding.","PeriodicalId":292211,"journal":{"name":"Current Trends in Toxicology and Pharmacology Research","volume":"278 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124472490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

In-Vitro Investigation of CPH Drug-Montmorillonite Clay Interaction CPH与蒙脱土相互作用的体外研究

Current Trends in Toxicology and Pharmacology Research Pub Date : 1900-01-01 DOI: 10.53902/cttpr.2021.01.000501

Adel Saeed

{"title":"In-Vitro Investigation of CPH Drug-Montmorillonite Clay Interaction","authors":"Adel Saeed","doi":"10.53902/cttpr.2021.01.000501","DOIUrl":"https://doi.org/10.53902/cttpr.2021.01.000501","url":null,"abstract":"The aim of the present work is to explore a naturally occurring clay mineral Montmorillonite (MMT), purified from raw Yemeni bentonite clay, as adsorbent material for ciprofloxacin hydrochloride antibiotic (CPH) in order to investigate the interaction of CPH and MMT. CPH-MMT composites were synthesized and the study design involved the investigation of the effect of three variables, namely; the time, pH and concentration of drug, on the intercalation process. The drug loading and recovery mechanisms were examined and supported by diffusion kinetics laws and adsorption isotherm models. The statistical analysis of the effect of different factors on the adsorption process showed that there was a significant difference in the amount of CPH drug that adsorbed due to variations in these factors. This study showed that the equilibrium time attained after 4 hours and the pH of the drug solution played a crucial role in the intercalation process and the adsorption isotherm was fitted by the Langmuir model with maximum adsorption and followed the pseudo-second-order kinetics. Ciprofloxacin hydrochloride is proved to successfully intercalate into the interlayers of MMT. The intercalation of a drug in MMT follows pseudo-second order kinetics. It is recommended that the overall rate of the adsorption procedure is expected to be controlled by the chemical adsorption process. The adsorption process follows the Langmuir model with a maximum amount of CPH intercalated in MMT being 263.15mg/g. This indicates the homogeneous nature of the MMT surface and the formation of monolayer coverage of CPH on the surface of MMT.","PeriodicalId":292211,"journal":{"name":"Current Trends in Toxicology and Pharmacology Research","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133590652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0