800 – Pharmacoepidemiology最新文献

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801 Factors associated with SLE flares after HCQ taper, discontinuation or maintenance in the SLICC inception cohort: lower education linked with higher flare risk 801 SLICC初始队列中HCQ逐渐减少、停药或维持后与SLE发作相关的因素:低教育程度与高发作风险相关

800 – Pharmacoepidemiology Pub Date : 2021-11-01 DOI: 10.1136/lupus-2021-lupus21century.38

C. Almeida-Brasil, J. Hanly, M. Urowitz, A. Clarke, R. Ramsey‐Goldman, C. Gordon, M. Petri, E. Ginzler, D. Wallace, S. Bae, J. Romero-Díaz, M. Dooley, C. Peschken, D. Isenberg, Anisur Rahman, S. Manzi, S. Jacobsen, Sam Lim, Ronald Van Vollenhoven, O. Nived, A. Jonsen, D. Kamen, C. Aranow, G. Ruiz‐Irastorza, J. Sánchez-Guerrero, D. Gladman, P. Fortin, G. Alarcón, J. Merrill, K. Kalunian, M. Ramos-Casals, K. Steinsson, A. Zoma, A. Askanase, M. Khamashta, I. Bruce, M. Inanç, S. Bernatsky

{"title":"801 Factors associated with SLE flares after HCQ taper, discontinuation or maintenance in the SLICC inception cohort: lower education linked with higher flare risk","authors":"C. Almeida-Brasil, J. Hanly, M. Urowitz, A. Clarke, R. Ramsey‐Goldman, C. Gordon, M. Petri, E. Ginzler, D. Wallace, S. Bae, J. Romero-Díaz, M. Dooley, C. Peschken, D. Isenberg, Anisur Rahman, S. Manzi, S. Jacobsen, Sam Lim, Ronald Van Vollenhoven, O. Nived, A. Jonsen, D. Kamen, C. Aranow, G. Ruiz‐Irastorza, J. Sánchez-Guerrero, D. Gladman, P. Fortin, G. Alarcón, J. Merrill, K. Kalunian, M. Ramos-Casals, K. Steinsson, A. Zoma, A. Askanase, M. Khamashta, I. Bruce, M. Inanç, S. Bernatsky","doi":"10.1136/lupus-2021-lupus21century.38","DOIUrl":"https://doi.org/10.1136/lupus-2021-lupus21century.38","url":null,"abstract":"was unaffected by the absence of plasminogen activator inhibitor1 or tissue plasminogen activator, suggesting that protection is related to the action of Serp-1 on macrophage function. Conclusions Serp-1 blocks pristane-induced lung hemorrhage by enhancing LXR-regulated M2 macrophage polarization and Klf4-regulated IL-10 production. In view of the similarities between DAH in pristane-treated mice and SLE patients, clinical trials of Serp-1 for DAH in SLE may be warranted. Since Serp-1 treatment increases expression of the reverse cholesterol transporter ABCA1, it also may have beneficial effects on atherosclerosis in SLE patients. Supporting the feasibility of future clinical studies in SLE, Serp-1 treatment reduced myocardial damage in patients with acute coronary syndrome. Acknowledgments This work was supported by NIH grant R01-AR44731. We are grateful to Dr. Alexandra Lucas (Arizona State University) for providing recombinant Serp-1 protein.","PeriodicalId":291970,"journal":{"name":"800 – Pharmacoepidemiology","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122726710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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