Modern applications in Pharmacy & Pharmacology最新文献

{"title":"Letter to the Editor: The Significance of Medicinal Herbs for Treating Candidiasis","authors":"Mehrnaz Molaei, M. Havasian","doi":"10.31031/mapp.2018.02.000534","DOIUrl":"https://doi.org/10.31031/mapp.2018.02.000534","url":null,"abstract":"Editorial Candida albicans grows in the growth medium or tissue as oval and budding yeast cells. Candidiasis is undoubtedly one of the most significant as well as most common opportunistic fungal diseases in humans. The infection is acute, sub-acute, or chronic that is often seen in the skin, nails, vaginal mucus, digestive system etc. The host’s reaction against this disease ranges from brief itching and inflammation to the chronic form, acute suppurative or granulomatous. Candida albicans is the main cause of 85-90% of Vulvovaginal candidiasis cases [1]. In fact, vulvovaginitis is common in most of the women receiving medical cares and every year more than 10 million people suffer from this complication. It has been estimated that from every 10 women, at least seven of them suffer from a fungal infection at least once in their lifetime, and from every 10 women, 4 will suffer from repeated recurrence. far candidiasis. far Inner abovementioned studies strains of candida albicans","PeriodicalId":289903,"journal":{"name":"Modern applications in Pharmacy & Pharmacology","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125280983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-inflammatory Potential of a Novel Imidazole Containing Murrayanine Based Chalcone","authors":"D. Mahapatra, Ruchi Shivhare","doi":"10.31031/MAPP.2018.02.000533","DOIUrl":"https://doi.org/10.31031/MAPP.2018.02.000533","url":null,"abstract":"Murrayanine is an active carbazole compound present in the Indian Curry tree, known as Murraya koenigii L. belonging to the family Rutaceae. Traditionally, it is known to exhibit anti-anemic, febrifuge, carminative, stomachic, purgative, astringent, and anthelmintic. The present research involved the synthesis of (E)-3-(4-(1H-imidazol-1-yl)phenyl)-1-(1-methoxy-9H-carbazol-3-yl)prop-2-en-1-one from murrayanine and 4-(imidazol-1-yl) acetophenone and exploring the anti-inflammatory activity of the fabricated hybrid. The current effort involved screening the significance of imidazole function present in the ring-B of the murrayanine-chalcone scaffold and their further optimization thereof with emphasis on structural aspects. A moderate edema reducing potential has been seen in the newly developed compound (3). As compared with the indomethacin, the standard drug, the chalcone exhibited impressive anti-inflammation effect after 3hrs. The activity may be mediated by inhibiting the pro-inflammatory constituents like cyclooxygenase-2 (COX-2) and lipoxygenase (5-LOX) which may be due to the imidazole group and benzylidene acetophenone scaffold. This study will open new avenues of research by promoting the development of more potent natural product based hybrid compounds with a high level of safety. In successive studies, more derivatives may be prepared to rationally study the structural influence over the activity and to derive information which will be of applied interest.","PeriodicalId":289903,"journal":{"name":"Modern applications in Pharmacy & Pharmacology","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127453517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Should “Medicinal Herbs” be a Mandatory Course for Pharmacy Students?","authors":"M. Sekar, Taylor Allen","doi":"10.31031/MAPP.2018.02.000532","DOIUrl":"https://doi.org/10.31031/MAPP.2018.02.000532","url":null,"abstract":"We suggest that since there is widespread use of herbal products by patients, the pharmacy community cannot truly claim expertise in all medications if we continue to ignore this important area of patient’s self-therapy. This commentary is based on our experience of offering elective “Medicinal Herbs” course at the University for past eight years. Every year, about twenty percent of the pharmacy students in their third professional year enroll in this elective; invariably, at the end of the course, more students report being more comfortable in recommending and counseling over herbal therapies for many more ailments than they were at the beginning of the course. Therefore, we suggest that a stand-alone foundational level course in medicinal herbs should be a part of Pharm D curriculum for all pharmacy students. Multiple patient surveys have indicated that patients rarely inform their healthcare professionals, including pharmacists, on their herbal use. Most likely reason for such patient’s behavior is the clear perception by the patient that most healthcare professionals trained in Western medicine have no expertise in this area and are most likely to “laugh” at the patient for his ignorance and engaging in such superstitious behavior.","PeriodicalId":289903,"journal":{"name":"Modern applications in Pharmacy & Pharmacology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131124787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Introduction to Computational Methods and Their Applications in Chemistry","authors":"K. Arora","doi":"10.31031/mapp.2018.02.000531","DOIUrl":"https://doi.org/10.31031/mapp.2018.02.000531","url":null,"abstract":"It is a demand in the modern era of chemical sciences to develop and design new and useful compounds for the service of mankind without the use of methods which are traditional one. Workers were trying to develop and synthesizing series of new compounds since past in the laboratories using traditional synthetic methods and they used to check their properties thereafter. This process is time consuming and this lead to synthesis of a large number of compounds. Some recent trends have been emerged and developed in the field of designing of compounds which may include microwave synthesis, computer aided designing etc. Out of these methods this present talk/presentation will focus on computer aided designing i.e. studying and designing of compounds of on the PC first without trying a lot of synthesis in the lab. These computational methods are less time consuming, involve less chances of error, helpful in controlling and causing less pollution and may prove to be helpful in designing compounds with desired properties. This paper/lecture includes introduction to the computational methods, a little theory behind these methods, their applications and use of software/s particularly use of software/s of semi-empirical methods in QSAR studies. ISSN 2637-7756 Mod Appl Pharm Pharmacol Copyright © Kishor Arora 2/6 How to cite this article: Kishor A. Introduction to Computational Methods and Their Applications in Chemistry. Mod Appl Pharm Pharmacol. 2(2). MAPP.000531. 2018. DOI: 10.31031/MAPP.2018.02.000531 Volume -2 Issue 2 a. The structure, or geometry of the molecule b. The property or properties of a molecule or system of molecules the activity, or reactivity, of a molecule or system of molecules. Fundamental approximations behind these techniques a. The Born-Oppenheimer approximation: states that we ignore the motion of nuclei in molecules b. The Hartree-Fock (HF) approximation: states that we can simplify our calculations by aggregating, or combining, the motion of electrons c. The Linear Combination of Atomic Orbitals (LCAO): states that we can construct molecular orbitals by a relatively straightforward addition of calculated atomic orbitals. d. Most molecular modeling tools look to solve the Schrodinger Equation, In its most well known format, the Schrodinger equation is represented by: H E Ψ = Ψ Basically modeling is a technique of solving this equation within these three approximations as represented by the (Figure 2). Figure 2: Basic model technique. Some software/methods in use for this purpose Figure 3: A comparative study of the packages/methods used/employed for modeling. There are three types of methods in use based on the consideration of electrons and formation of Hamiltonian to solve the Schrodinger equation set up for the molecular system [4-7]. These are viz. semi-empirical, ab-initio and density functional methods. Some common software which is in use now-a days are: a. MOPAC b. HYPERCHEM c. GAMESS d. Gaussian etc. These are used with dif","PeriodicalId":289903,"journal":{"name":"Modern applications in Pharmacy & Pharmacology","volume":"461 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127012393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}