Journal of Science and Technology (Ghana)最新文献

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Anti-hyperglycaemic and anti-oxidant activities of five Nigerian antidiabetic plants 五种尼日利亚抗糖尿病植物的抗高血糖和抗氧化活性

Journal of Science and Technology (Ghana) Pub Date : 2019-06-24 DOI: 10.4314/JUST.V37I2

M. Ayoola, A. C. Adebajo, E. Obuotor, T. Oladapo, T. C. Fleischer

{"title":"Anti-hyperglycaemic and anti-oxidant activities of five Nigerian antidiabetic plants","authors":"M. Ayoola, A. C. Adebajo, E. Obuotor, T. Oladapo, T. C. Fleischer","doi":"10.4314/JUST.V37I2","DOIUrl":"https://doi.org/10.4314/JUST.V37I2","url":null,"abstract":"Leaves of Olax subscorpioidea, Hoslundia opposita, Cleistopholis patens, Plumbago zeylanica and Dioscoreophyllum cumminsii that are used as anti-diabetics were evaluated for hyperglycaemic-lowering and antioxidant activities to justify their Nigerian ethnomedicinal usage. Leaf methanolic extracts (100, 200 and 400 mg/kg, p.o.) were assayed in normal, glucose- and alloxan-induced diabetic rats, while 1,1,-diphenyl-2-picrylhydrazyl, total antioxidant capacity, ferric reducing antioxidant power and hydroxyl radical scavenging tests were used for their antioxidant activity. Effects of n-hexane, dichloromethane, ethylacetate and aqueous partition fractions of the three most active anti-hyperglycaemic extracts were also tested in glucose-loaded rats. In normoglycaemic rats, all extracts generally lacked activity, while with glucose-loaded rats, only O. subscorpioidea (200mg/kg) and C. patens (400 mg/kg) at 1 h and O. subscorpioidea (200, 400 mg/kg) and C. patens (400 mg/kg) at 2-4 hours gave lowered (p < 0.05) blood glucose levels than glibenclamide (5 mg/kg), while activity of H. opposita and P. zeylanica (200 mg/kg) were only comparable to glibenclamide. When daily fed for fourteen days to alloxan-induced diabetic rats, all extracts, at their most active doses, gave significantly higher activity than glibenclamide. Olax subscorpioidea leaf extract had the highest hyperglycaemic-lowering and least antioxidant activities. Highest antioxidant activity of H. opposita may suggest some contribution of antioxidant property to its hyperglycaemic-lowering activity. The glucose-lowering and insulinotropic constituents of O. subscorpioidea, H. opposita and C. patens should be concentrated in their aqueous, aqueous and dichloromethane fractions, respectively. Anti-hyperglycaemic ethnomedicinal use of these plants was justified and H. opposita has additional antioxidant property. Keywords: Antioxidant activity; Diabetes mellitus; Nigerian anti-diabetic plants ","PeriodicalId":288279,"journal":{"name":"Journal of Science and Technology (Ghana)","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116645535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Analysis of gender representation in basic level English textbooks in Ghana 加纳基础英语教材中的性别代表性分析

Journal of Science and Technology (Ghana) Pub Date : 2019-06-24 DOI: 10.4314/JUST.V37I2.8

Francis Kofi Nimo Nunoo, D. Mensah, E. Boahen, I. Nunoo

引用次数: 3