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Drug repurposing against COVID-19 by GWAS GWAS针对COVID-19的药物再利用
Health Biotechnology and Biopharma Pub Date : 1900-01-01 DOI: 10.22034/HBB.2020.01
Mohammad Afzal, S. Sardari, S. Sikandar, Imran Afzal
{"title":"Drug repurposing against COVID-19 by GWAS","authors":"Mohammad Afzal, S. Sardari, S. Sikandar, Imran Afzal","doi":"10.22034/HBB.2020.01","DOIUrl":"https://doi.org/10.22034/HBB.2020.01","url":null,"abstract":"This note is prepared by the authors of a recent publication on shared genetic architecture of drug response based on summary statistics from genome-wide association studies (GWAS) to propose a drug repurposing approach for the treatment of coronavirus COVID-19. The authors proposed that in silico studies may be preceded by analyzing shared genetic architecture of drug response based on existing GWAS. © 2020, Health Biotechnology and Biopharma.","PeriodicalId":288173,"journal":{"name":"Health Biotechnology and Biopharma","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122548456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel coronavirus disease-19:An overviwe of pathogenesis, health influences and measures 新型冠状病毒病-19:发病机制、健康影响及对策综述
Health Biotechnology and Biopharma Pub Date : 1900-01-01 DOI: 10.22034/HBB.2020.08
M. Radhi, Fatima Malik Abood AL-Rubea, Iman Fadhel Abdul-Hussin, N. Hindi, R. AL-Jubori
{"title":"Novel coronavirus disease-19:An overviwe of pathogenesis, health influences and measures","authors":"M. Radhi, Fatima Malik Abood AL-Rubea, Iman Fadhel Abdul-Hussin, N. Hindi, R. AL-Jubori","doi":"10.22034/HBB.2020.08","DOIUrl":"https://doi.org/10.22034/HBB.2020.08","url":null,"abstract":"The coronavirus disease-19 (COVID-19) signs mostly include fever and respiratory symptoms (unusual viral pneumonia by SARS-Coronaviruses 2 or SARS-CoV-2). The Receptor-Binding Domain (RBD) of COVID-19 and SARS-CoV are similar, causing cross-reactivity of anti-SARSCoV antibodies with associated spike protein, exerting promising implications for rapid development of vaccines and therapeutic antibodies against COVID-19. ACE2 is the SARS TMPRSS2 for spike (S) protein receptor for initiation of infection;hence, it is a target for pharmacological intervention. Furthermore, designing novel monoclonal antibodies binding specifically to COVID-19 RBD is essential. A viral S proteins (TMPRSS2) was proposed for clinical use by blocking the viral intake by cell.Copyright © 2020, Health Biotechnology and Biopharma. All rights reserved.","PeriodicalId":288173,"journal":{"name":"Health Biotechnology and Biopharma","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126579004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New insights into the effects of hydroxychloroquine in COVID-19 羟氯喹治疗COVID-19的新见解
Health Biotechnology and Biopharma Pub Date : 1900-01-01 DOI: 10.22034/HBB.2021.13
F. Pouya, Yousef Rasmi, M. Nemati
{"title":"New insights into the effects of hydroxychloroquine in COVID-19","authors":"F. Pouya, Yousef Rasmi, M. Nemati","doi":"10.22034/HBB.2021.13","DOIUrl":"https://doi.org/10.22034/HBB.2021.13","url":null,"abstract":"In late 2019 until 2021, the novel coronavirus disease (COVID-19) has become pandemic. This disease is related to severe inflammatory symptoms of the respiratory epithelial cells and the dysfunction of several organs. One of the suggested drugs to reduce the inflammation caused by COVID-19 is hydroxychloroquine. Studies have shown this drug blocks the inflammatory pathway of nuclear factor-κB by blocking P21 activated kinase 1. Also, nanoparticle vaccines Poly Lactide-Glycolide) Acid (PLGA) containing hydroxychloroquine are effective in cancer by stimulating CD8T + cells responses. This study assumed that hydroxychloroquine was effective in inhibiting COVID-19 with these mechanisms. © 2021 Health Biotechnology And Biopharma. All Rights Reserved.","PeriodicalId":288173,"journal":{"name":"Health Biotechnology and Biopharma","volume":"85 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134413578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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