Parkinson's Disease and Beyond - A Neurocognitive Approach最新文献

Introductory Chapter: Targeting Unmet Needs in Parkinson’s Disease 导论章:针对帕金森病未满足的需求

Parkinson's Disease and Beyond - A Neurocognitive Approach Pub Date : 2019-06-19 DOI: 10.5772/INTECHOPEN.86396

S. Palermo, R. Morese, M. Stanziano

引用次数: 3

Levodopa-Induced Dyskinesias and Dyskinesias-Reduced-Self-Awareness in Parkinson’s Disease: A Neurocognitive Approach 左旋多巴诱导的帕金森病运动障碍和运动障碍-自我意识降低:一种神经认知方法

Parkinson's Disease and Beyond - A Neurocognitive Approach Pub Date : 2019-05-16 DOI: 10.5772/INTECHOPEN.86384

S. Palermo, R. Morese, C. Artusi, M. Stanziano, A. Romagnolo

{"title":"Levodopa-Induced Dyskinesias and Dyskinesias-Reduced-Self-Awareness in Parkinson’s Disease: A Neurocognitive Approach","authors":"S. Palermo, R. Morese, C. Artusi, M. Stanziano, A. Romagnolo","doi":"10.5772/INTECHOPEN.86384","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.86384","url":null,"abstract":"Levodopa-induced dyskinesias are one of the most common disabling motor complications in advanced Parkinson’s disease. The subjective perception of motor impairment is a clinical phenomenon that needs to be adequately analyzed. Indeed, the determination of patient dyskinesias-reduced-self-awareness (DRSA) and of its relationship to daily dysfunction is an important aspect of the debate on the gold standard for treatment. As the association with executive dysfunction is a matter of debate and we hypothesize it plays an important role in DRSA, we analyzed metacognitive abilities related to action monitoring and other factors, such as response-inhibition and “Theory of Mind,” which represent a novel explanation of the phenomenon. Moreover, we investigated whether and how a dysfunction in action monitoring related to the cingulo-frontal-ventral striatal circuit would be associated with DRSA using an event-related Go-NoGo fMRI experiment. Our findings suggest the presence of executive dysfunctions in DRSA pathogenesis, with a key leading role played by the cingulo-frontal network as part of a functionally impaired response-inhibition network.","PeriodicalId":286199,"journal":{"name":"Parkinson's Disease and Beyond - A Neurocognitive Approach","volume":"49 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132766848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 175

Neuroimaging in Parkinson Disease 帕金森病的神经影像学

Parkinson's Disease and Beyond - A Neurocognitive Approach Pub Date : 2019-05-06 DOI: 10.5772/INTECHOPEN.82308

Roohi Mohammad, F. Mubarak

引用次数: 2

Mitochondrial KATP Channel and Dopaminergic Vulnerability Neurons in Parkinson’s Disease 帕金森病的线粒体KATP通道和多巴胺能易损神经元

Parkinson's Disease and Beyond - A Neurocognitive Approach Pub Date : 2019-03-12 DOI: 10.5772/INTECHOPEN.81862

Gesivaldo Santos, Julita Maria Pereira Borges, Marcos Avilla-Rodriguez, Érika Pereira Rubio, Cattiúscia Batista Bromochenkel, Djalma Menezes Oliveira, Jane Lima dos Santos, Rosane Moura Aguiar, Milena Mascarenhas Ferraz, Silvana Batista Gaino, F. Capani, George E. Barreto

{"title":"Mitochondrial KATP Channel and Dopaminergic Vulnerability Neurons in Parkinson’s Disease","authors":"Gesivaldo Santos, Julita Maria Pereira Borges, Marcos Avilla-Rodriguez, Érika Pereira Rubio, Cattiúscia Batista Bromochenkel, Djalma Menezes Oliveira, Jane Lima dos Santos, Rosane Moura Aguiar, Milena Mascarenhas Ferraz, Silvana Batista Gaino, F. Capani, George E. Barreto","doi":"10.5772/INTECHOPEN.81862","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.81862","url":null,"abstract":"The motor deficiency control commonly characterizes Parkinson’s disease (PD), resulting in impairment of neuromuscular command, because of basal ganglia nuclei degeneration and late formation of Lewy’s bodies in the remaining dopaminergic (DA) neurons. Motor signals are triggered in high cortical motor areas and go toward the midbrain regions, where the final tuning movement takes place. PD is characterized primarily by the death of dopaminergic neurons in the regions known as substantia nigra compacta (STNc). Mutations in a couple of genes, such as Parkin1 and DJ1, correspond to the usual familial form of the disease, due to its association with oxidative stress and depolarization of mitochondrial membrane. However, this form does not explain the selective pattern of apoptosis between the neuronal dopaminergic areas of midbrain regions. In this chapter, we are putting forward the hypothesis of oxidative stress and mitochondrial changes as the apparent most relevant cause in PD, as well as the neuroprotective role played by Kir6.2, a potassium-ATP channel and calcium voltage-gated v1.3.","PeriodicalId":286199,"journal":{"name":"Parkinson's Disease and Beyond - A Neurocognitive Approach","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130893837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Causative and Curative Roles of Brain-Derived Neurotrophic Factor in Parkinson’s Disease 脑源性神经营养因子在帕金森病中的病因和治疗作用

Parkinson's Disease and Beyond - A Neurocognitive Approach Pub Date : 2018-11-08 DOI: 10.5772/INTECHOPEN.81215

D. Hernandez-Baltazar, Rasajna Nadella, Tamara Cibrián-Llanderal, Abraham Puga-Olguín, Abril Alondra Barrientos-Bonilla, L. Zavala-Flores, Arnulfo Villanueva-Olivo, A. Sánchez-García, M. J. Rovirosa-Hernández, J. D. Rembao-Bojórquez

{"title":"The Causative and Curative Roles of Brain-Derived Neurotrophic Factor in Parkinson’s Disease","authors":"D. Hernandez-Baltazar, Rasajna Nadella, Tamara Cibrián-Llanderal, Abraham Puga-Olguín, Abril Alondra Barrientos-Bonilla, L. Zavala-Flores, Arnulfo Villanueva-Olivo, A. Sánchez-García, M. J. Rovirosa-Hernández, J. D. Rembao-Bojórquez","doi":"10.5772/INTECHOPEN.81215","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.81215","url":null,"abstract":"Parkinson ’ s disease (PD) is characterized by the activation of degenerative and inflammatory processes in brain circuits that control movement and, according to the degree of progression of the damage, can cause neuropsychological disorders such as cognitive dysfunction. Changes in gene expression profile or post-translational mod-ifications in secretory proteins such as neurotrophic factors could define the disease progression. Brain-derived neurotrophic factor (BDNF) is relevant, because it not only participates in neuronal survival, neurotransmission, dendritic growth and cellular communication but also in disease progression. In this chapter, considering both experimental evidences and clinical reports, the authors will analyze the contri-bution of BDNF as one of the causes of neurodegeneration and neuroinflammation; discuss the participation of this neurotrophic factor in the development of cognitive dysfunction, and finally the scope of novel BDNF-based therapies for PD.","PeriodicalId":286199,"journal":{"name":"Parkinson's Disease and Beyond - A Neurocognitive Approach","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114916462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2