Pocket Guide to Critical Care Pharmacotherapy最新文献

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Infectious Disease 传染性疾病
Pocket Guide to Critical Care Pharmacotherapy Pub Date : 2015-06-15 DOI: 10.1093/med/9780199660155.003.0011
Erica Smith
{"title":"Infectious Disease","authors":"Erica Smith","doi":"10.1093/med/9780199660155.003.0011","DOIUrl":"https://doi.org/10.1093/med/9780199660155.003.0011","url":null,"abstract":"Tularemia, caused by Francisella tularensis, is a sporadic zoonotic disease with the potential to be an agent of biowarfare or bioterrorism. We describe here the gross, histologic, immunohistochemical, and ultrastructural findings in a group of 5 African green monkeys (AGMs) that received an average inhaled dose of 729 colony-forming units of F. tularensis and died or were euthanatized between days 7 and 11 post infection. Clinical changes were evident by 48 hours post infection, and key physiologic abnormalities included increases in body temperature, heart rate, peak cardiac pressure, and mean blood pressure. Prominent gross changes in all cases included numerous pinpoint to 1-cm, well-demarcated, necrotic foci present consistently in the lungs, mediastinal lymph nodes, and spleen but also seen in the heart, mediastinum, diaphragm, liver, urinary bladder, urethra, and mesentery. The lungs, mediastinal lymph nodes, and spleen were most severely affected, with as much as 50% of the tissue replaced by necrotic foci. Histologic changes in all tissues consisted of welldelineated foci of necrosis and neutrophilic and histiocytic inflammation, with varying amounts of hemorrhage, edema, fibrin, and vasculitis. Some lesions were immature pyogranulomas. Strong immunoreactivity was identified primarily within macrophages. Ultrastructurally, bacteria were present within cytoplasmic vacuoles of alveolar macrophages, many of which were degenerate. In summary, AGMs infected with F. tularensis by aerosol develop lethal multisystemic disease that particularly targets the lungs and lymphoid tissues. Thus, AGMs should serve as a suitable and reliable animal model for further studies of tularemia.","PeriodicalId":285296,"journal":{"name":"Pocket Guide to Critical Care Pharmacotherapy","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116848013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Infectious Diseases 传染病
Pocket Guide to Critical Care Pharmacotherapy Pub Date : 2014-10-25 DOI: 10.1007/978-1-4939-1853-9_9
J. Papadopoulos
{"title":"Infectious Diseases","authors":"J. Papadopoulos","doi":"10.1007/978-1-4939-1853-9_9","DOIUrl":"https://doi.org/10.1007/978-1-4939-1853-9_9","url":null,"abstract":"","PeriodicalId":285296,"journal":{"name":"Pocket Guide to Critical Care Pharmacotherapy","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116463350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Critical Care 急救护理
Pocket Guide to Critical Care Pharmacotherapy Pub Date : 2014-10-25 DOI: 10.1007/978-1-4939-1853-9_4
J. Papadopoulos
{"title":"Critical Care","authors":"J. Papadopoulos","doi":"10.1007/978-1-4939-1853-9_4","DOIUrl":"https://doi.org/10.1007/978-1-4939-1853-9_4","url":null,"abstract":"","PeriodicalId":285296,"journal":{"name":"Pocket Guide to Critical Care Pharmacotherapy","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129620424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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