Frontiers in Clinical Drug Research - Anti-Infectives最新文献

{"title":"Nanoantibiotics: Recent Developments and Future Prospects","authors":"M. Ovais, N. Zia, A. Khalil, M. Ayaz, Amjad Khalil, Irshad Ahmad","doi":"10.2174/9781681086378119050006","DOIUrl":"https://doi.org/10.2174/9781681086378119050006","url":null,"abstract":"","PeriodicalId":278269,"journal":{"name":"Frontiers in Clinical Drug Research - Anti-Infectives","volume":"74 4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114940681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Use of Commensal Microbes: Fecal/Gut Microbiota Transplantation","authors":"P. A. Vanny, Aline Machiavelli, Catherine W. Wippel, Jessica Rodrigues de Andrade, C. P. Zamparette, D. C. Tartari, T. Sincero, A. R. Pinto, C. Zárate-Bladés","doi":"10.2174/9781681086378119050004","DOIUrl":"https://doi.org/10.2174/9781681086378119050004","url":null,"abstract":"","PeriodicalId":278269,"journal":{"name":"Frontiers in Clinical Drug Research - Anti-Infectives","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124965247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alternative Approaches to Antimicrobials","authors":"A. Filazi, B. Yurdakok-Dikmen","doi":"10.2174/9781681086378119050005","DOIUrl":"https://doi.org/10.2174/9781681086378119050005","url":null,"abstract":"","PeriodicalId":278269,"journal":{"name":"Frontiers in Clinical Drug Research - Anti-Infectives","volume":"88 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126206734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting Magnesium Homeostasis as Potential Anti-infective Strategy Against Mycobacteria","authors":"S. Hameed, Z. Fatima","doi":"10.2174/9781681086378119050008","DOIUrl":"https://doi.org/10.2174/9781681086378119050008","url":null,"abstract":"","PeriodicalId":278269,"journal":{"name":"Frontiers in Clinical Drug Research - Anti-Infectives","volume":"58 2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122290462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"List of Contributors","authors":"","doi":"10.2174/9781681086378119050002","DOIUrl":"https://doi.org/10.2174/9781681086378119050002","url":null,"abstract":"","PeriodicalId":278269,"journal":{"name":"Frontiers in Clinical Drug Research - Anti-Infectives","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116292355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cranberry Juice and Other Functional Foods in Urinary Tract Infections in Women: A Review of Actual Evidence and Main Challenges","authors":"R. Monroy-Torres, Ana Karen Medina-Jiménez","doi":"10.2174/9781681086378119050007","DOIUrl":"https://doi.org/10.2174/9781681086378119050007","url":null,"abstract":"","PeriodicalId":278269,"journal":{"name":"Frontiers in Clinical Drug Research - Anti-Infectives","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114890591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frontiers in Clinical Drug Research - Anti-Infectives: Volume 5","authors":"Atta-ur- Rahman","doi":"10.2174/97816810863781190501","DOIUrl":"https://doi.org/10.2174/97816810863781190501","url":null,"abstract":"","PeriodicalId":278269,"journal":{"name":"Frontiers in Clinical Drug Research - Anti-Infectives","volume":"91 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122937179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated Approaches for Marine Actinomycete Biodiscovery","authors":"Larissa Buedenbender","doi":"10.2174/9781681086378119050003","DOIUrl":"https://doi.org/10.2174/9781681086378119050003","url":null,"abstract":"This PhD project examined integrated approaches for marine actinomycete biodiscovery. A \u0000library of 120 actinomycete strains derived from the three Australian ascidians, Symplegma \u0000rubra, Aplidium solidium and Polyclinum vasculosum, was established in order to access new \u0000chemical diversity of underexplored marine ecological niches for natural product drug \u0000discovery. Specifically, the genera Streptomyces and Micromonospora were highly diverse and \u0000abundantly present, while fewer Nocardia and Rhodococcus and only one Streptosporangium \u0000representative were isolated. Only two isolates occurred in all three ascidians indicating speciesspecificity \u0000of actinomycetes in the ascidian. LC-MS/MS profiling of extracts obtained from the \u0000ascidians and their actinomycete associates revealed many overlapping ions between hosts and \u0000cultured isolates indicating that these compounds were likely to be synthesised by the microbial \u0000associates. Laboratory cultures of the actinomycetes displayed even more diverse metabolomes \u0000than those of their ascidian hosts; thus making ascidian-associated actinomycetes an excellent \u0000target for biodiscovery. \u0000Reisolation of already known compounds is a major obstacle to natural product drug \u0000discovery; therefore, sophisticated dereplication approaches have to be employed in the early \u0000stages of discovery. To facilitate the dereplication, a new strain prioritisation approach using \u0000HSQC-TOCSY NMR spectra together with anti-plasmodial activity data was developed. This \u0000allowed for prioritisation of microbial strains that are more likely to produce diverse polyketide \u0000or peptide natural products. This approach was further validated through dereplication of monoand \u0000co-culture extracts of four different microbial strains. HSQC-TOCSY NMR profiles of the \u0000extracts clearly showed co-cultivation induced changes in the microbial metabolomes. \u0000Streptomyces sp. (USC-16018) was selected based on the strain prioritisation approach and \u0000large-scale fermentations led to the isolation of a new ansamycin polyketide, herbimycin G with \u0000weak anti-plasmodial activity (77 % at 40 μM), as well as the known compounds elaiophylin, \u0000and the four diketiopiperazines, Cyclo-L-Pro-L-Leu, Cyclo-L-Pro-L-Phe, Cyclo-L-Pro-L-Val and \u0000Cyclo-L-Pro-L-Tyr. The crude NMR profile of the sediment-derived Streptomyces sp. (USC- \u0000636) revealed the presence of indole-associated signals and three tryptophan containing \u0000diketopiperazines, naseseazine A – C, were isolated. The new compound naseseazine C \u0000exhibited moderate anti-plasmodial activity (IC50 3.52 μM). \u0000Overall, this thesis highlights the immense chemical diversity of actinomycetes from marine \u0000sources, as well as the importance of sophisticated dereplication approaches and provides an \u0000alternative new solution for strain selection that has led to the discovery of new bioactive natural products with potential as new drug leads.","PeriodicalId":278269,"journal":{"name":"Frontiers in Clinical Drug Research - Anti-Infectives","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134255085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}