Receptors P1 and P2 as Targets for Drug Therapy in Humans最新文献

Functions of Purinergic Receptors 嘌呤能受体的功能

Receptors P1 and P2 as Targets for Drug Therapy in Humans Pub Date : 2019-12-24 DOI: 10.5772/intechopen.88251

E. Sarıkaya

引用次数: 0

Purinergic Signaling and Dental Orofacial Pain 嘌呤能信号与口腔面部疼痛

Receptors P1 and P2 as Targets for Drug Therapy in Humans Pub Date : 2019-11-28 DOI: 10.5772/intechopen.87181

Xiuxin Liu

{"title":"Purinergic Signaling and Dental Orofacial Pain","authors":"Xiuxin Liu","doi":"10.5772/intechopen.87181","DOIUrl":"https://doi.org/10.5772/intechopen.87181","url":null,"abstract":"Pain is a common complaint of patients in the dental clinic. Patient with dental orofacial pain usually presents with hyperalgesia and allodynia. Its management has been a challenge, especially in the status of chronic pain or neuropathic pain. Purinergic signaling is dictated by ATP release, purinergic receptors activation, and sequential hydrolysis of ATP. Purinergic signaling participates in nociception processing in the sensory nerves by control of pain signal transduction, modulation, and sensitization. Since purinergic receptors are preferentially expressed in trigeminal nerves, purinergic singling may play a crucial role in the development of dental orofacial pain. In this chapter, we overview the expressions of purinergic receptors as well as the machinery for ATP release, ATP degradations, and adenosine generation in trigeminal nerves. Specifically, the roles of ATP signaling in dental orofacial pain generation and central sensitization via activation of P2 receptors and adenosine signaling in analgesia via activation of P1 receptors in trigeminal nerves are updated. We also discuss the affection of ecto-nucleotidases, the major enzymes responsible for extracellular ATP degradation and adenosine generation in trigeminal nerves that drive the shift from ATP-induced pain to adenosine-induced analgesia. This chapter provides advanced outlines for purinergic signaling in trigeminal nerves and unveils potential therapeutic targets for the management of dental orofacial pain.","PeriodicalId":273495,"journal":{"name":"Receptors P1 and P2 as Targets for Drug Therapy in Humans","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130574796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Purinergic Signaling in the Pathophysiology of Perinatal Hypoxic-Ischemic Encephalopathy 嘌呤能信号在围产期缺氧缺血性脑病病理生理中的作用

Receptors P1 and P2 as Targets for Drug Therapy in Humans Pub Date : 2019-07-30 DOI: 10.5772/INTECHOPEN.86425

Tagore M. Morais-Lima, J. Vicentini, A. P. Alberto, Pedro Henrique Moreira de Freitas, C. Perret, Natiele Carla da Silva Ferreira, Deepaneeta Sarmah, B. Sinha, G. Das, P. Bhattacharya, Xin Wang, L. A. Alves, R. Rozental

{"title":"The Role of Purinergic Signaling in the Pathophysiology of Perinatal Hypoxic-Ischemic Encephalopathy","authors":"Tagore M. Morais-Lima, J. Vicentini, A. P. Alberto, Pedro Henrique Moreira de Freitas, C. Perret, Natiele Carla da Silva Ferreira, Deepaneeta Sarmah, B. Sinha, G. Das, P. Bhattacharya, Xin Wang, L. A. Alves, R. Rozental","doi":"10.5772/INTECHOPEN.86425","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.86425","url":null,"abstract":"Perinatal hypoxic-ischemic encephalopathy (HIE), known as birth asphyxia, remains a major contributor to poor neurodevelopmental outcomes including cerebral palsy and seizures. One striking feature of HIE injury is a delayed progression of neuronal degeneration that spreads over time from the most severely damaged areas outward into neighboring undamaged regions. There is increasing evidence that these lesions act as sites of origin for waves of spreading depression (SD), a wave of neuronal and glial depolarization, that progressively enlarge the brain lesions. While the pathophysiology of SD is still under debate, there is increasing evidence that purinergic receptors in conjunction with connexin and pannexin 1 channels are necessary for sustained propagation of the waves and neuroinflammation. This review intends to discuss the relative contribution of purinergic signaling and connexin and pannexin 1 channels to trigger and spread SD waves leading to the development of progressive brain lesions under conditions of perinatal HIE.","PeriodicalId":273495,"journal":{"name":"Receptors P1 and P2 as Targets for Drug Therapy in Humans","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126854322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Brief View of Molecular Modeling Approaches to P2 Receptors P2受体分子模拟方法综述

Receptors P1 and P2 as Targets for Drug Therapy in Humans Pub Date : 2019-07-30 DOI: 10.5772/INTECHOPEN.86862

A. P. Alberto, L. Santos, R. Ferreira, D. N. M. Ferreira, L. A. Alves

{"title":"A Brief View of Molecular Modeling Approaches to P2 Receptors","authors":"A. P. Alberto, L. Santos, R. Ferreira, D. N. M. Ferreira, L. A. Alves","doi":"10.5772/INTECHOPEN.86862","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.86862","url":null,"abstract":"Purinergic receptors are a class of receptors distributed into two groups, P1 and P2. P1 receptors are activated by nucleosides, like adenosine, while nucleotides active P2 receptors. In turn, P2 receptors comprise two families, metabotropic P2Y and ionotropic P2X. P2Y receptors consist in eight members, namely, P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and P2Y14, described in mammals, while P2X includes seven members, numbered P2X1 to P2X7. These receptors have been described as expressed in practically all cells studied to date. In this context, P2 receptors are suggested as participating in certain diseases. The general approach applied in the discovery of new drugs is expensive and lengthy. Alternatively, in the last 20 years, molecular modeling has emerged as an exciting tool for the design of new drugs, in less time and at low costs. These tools allow for in silico testing of thousands of molecules against a target protein, as well as toxicity, absorption, distribution, metabolism, and constant affinity predictions of a given interaction. Thus, molecular modeling algorithms emerge as an increasingly important tool for the design of drugs targeting purinergic receptors as therapeutic targets of many diseases, including cancer, pain, inflammation, cardiovascular, and endocrine conditions.","PeriodicalId":273495,"journal":{"name":"Receptors P1 and P2 as Targets for Drug Therapy in Humans","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132083332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1