C‐H Activation for Asymmetric Synthesis最新文献

{"title":"Substrate‐Controlled Transformation: Diastereoselective Functionalization","authors":"Shengyi Yan, B. Liu, Bing‐Feng Shi","doi":"10.1002/9783527810857.ch4","DOIUrl":"https://doi.org/10.1002/9783527810857.ch4","url":null,"abstract":"","PeriodicalId":265214,"journal":{"name":"C‐H Activation for Asymmetric Synthesis","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130853953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stereoselective\u0000 \u0000 C\u0000 \u0000 \u0000 \u0000 N\u0000 \u0000 Bond‐Forming Reactions Through\u0000 \u0000 C\u0000 \u0000 (\u0000 \u0000 sp\u0000 \u0000 3\u0000 \u0000 ","authors":"P. Dauban, Romain Rey-Rodriguez, Ali Nasrallah","doi":"10.1002/9783527810857.ch2","DOIUrl":"https://doi.org/10.1002/9783527810857.ch2","url":null,"abstract":"","PeriodicalId":265214,"journal":{"name":"C‐H Activation for Asymmetric Synthesis","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126479942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Central Chirality via Asymmetric\u0000 C\u0000 (\u0000 \u0000 sp\u0000 2\u0000 \u0000 )–\u0000 H\u0000 Activation Implying Desymmetrization and Kinetic Resolution","authors":"Soufyan Jerhaoui, F. Colobert, J. Wencel‐Delord","doi":"10.1002/9783527810857.ch7","DOIUrl":"https://doi.org/10.1002/9783527810857.ch7","url":null,"abstract":"","PeriodicalId":265214,"journal":{"name":"C‐H Activation for Asymmetric Synthesis","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132799010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diastereoselective Formation of Alkenes Through\u0000 C\u0000 (\u0000 sp\u0000 2\u0000 )\u0000 H\u0000 Bond Activation","authors":"Parthasarathy Gandeepan, L. Ackermann","doi":"10.1002/9783527810857.ch9","DOIUrl":"https://doi.org/10.1002/9783527810857.ch9","url":null,"abstract":"","PeriodicalId":265214,"journal":{"name":"C‐H Activation for Asymmetric Synthesis","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123783529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non‐stereoselective C(sp\u0000 2\u0000 )–\u0000 H\u0000 Activation Followed by Selective Functionalization of Metallacyclic Intermediate","authors":"Xiaohong Chen, X. Gong, Bo Wang, G. Song","doi":"10.1002/9783527810857.ch8","DOIUrl":"https://doi.org/10.1002/9783527810857.ch8","url":null,"abstract":"","PeriodicalId":265214,"journal":{"name":"C‐H Activation for Asymmetric Synthesis","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117005574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enantioselective Intra‐ and Intermolecular Couplings","authors":"Qiaoqiao Teng, Wei-Liang Duan","doi":"10.1002/9783527810857.ch3","DOIUrl":"https://doi.org/10.1002/9783527810857.ch3","url":null,"abstract":"","PeriodicalId":265214,"journal":{"name":"C‐H Activation for Asymmetric Synthesis","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121738101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Planar Chirality via C(sp\u0000 2\u0000 )–H Activation Involved in Stereodiscriminant Step","authors":"Q. Gu, S. You","doi":"10.1002/9783527810857.ch5","DOIUrl":"https://doi.org/10.1002/9783527810857.ch5","url":null,"abstract":"","PeriodicalId":265214,"journal":{"name":"C‐H Activation for Asymmetric Synthesis","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116836139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stereoselective\u0000 C\u0000 \u0000 C\u0000 Bond‐Forming Reactions Through\u0000 C\u0000 (\u0000 sp\u0000 3\u0000 )\u0000 H\u0000 Bond Insertion of Metal Carbenoids","authors":"Aoife M. Buckley, Thomas A. Brouder, A. Ford, A. Maguire","doi":"10.1002/9783527810857.ch1","DOIUrl":"https://doi.org/10.1002/9783527810857.ch1","url":null,"abstract":"The selective and efficient construction of complex molecules is one of the most challenging goals in organic synthesis. To access such intriguing molecules, innovative methodologies in bond formation are required compared to traditional functional group transformations. It is for this reason that selective functionalization of the ubiquitous but inert C—H bond is of great interest to the chemical community [1–4]. A challenging aspect in organic chemistry for decades has been the stereoselective carbon–carbon bond formation by activation of a C(sp3)—H bond in the synthesis of pharmaceuticals, natural products, and other industrially relevant targets. A powerful approach to achieve such useful C–H functionalization is via C(sp3)–H insertion by metal carbenoids [5–8]. Generation of the metal carbenoid can occur through a number of precursors such as diazo compounds, ylide derivatives, hydrazones, and, more recently, triazoles. In this chapter, we will exclusively discuss metal carbenoids derived from α-diazocarbonyl compounds. In order to take advantage of metal carbenoid-induced C–H insertion, one must consider the reactivity of the electrophilic metal carbenoid. The synthetic utility of the free carbenes is limited by low selectivity in most reactions. In contrast, when nitrogen extrusion is facilitated by a transition metal, the resulting metal carbenoid retains the reaction scope of a free carbene while allowing highly selective transformations to occur (Figure 1.1). Historically, copper was used as the transition metal source, but few examples of efficient and selective C–H insertion were reported. The key development in C–H insertion was the discovery by the Teyssié group that dirhodium(II) carboxylates catalyzed the intermolecular C–H insertion reaction of ethyl diazoacetate with alkanes [9]. Following this, Wenkert et al. [10] and Taber and Petty [11] highlighted the potential of intramolecular C–H insertion reactions of α-diazocarbonyl compounds to lead to cyclopentanone derivatives. Importantly, it was demonstrated that C–H insertion takes place with retention of","PeriodicalId":265214,"journal":{"name":"C‐H Activation for Asymmetric Synthesis","volume":"102 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123273771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Index","authors":"","doi":"10.1002/9783527810857.index","DOIUrl":"https://doi.org/10.1002/9783527810857.index","url":null,"abstract":"","PeriodicalId":265214,"journal":{"name":"C‐H Activation for Asymmetric Synthesis","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116758991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Axial Chirality via C(sp\u0000 2\u0000 )–H Activation Involved in Stereodiscriminant Step","authors":"Quentin Dherbassy, J. Wencel‐Delord, F. Colobert","doi":"10.1002/9783527810857.ch6","DOIUrl":"https://doi.org/10.1002/9783527810857.ch6","url":null,"abstract":"","PeriodicalId":265214,"journal":{"name":"C‐H Activation for Asymmetric Synthesis","volume":"362 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132408984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}