1200 - COVID-19最新文献

1206 Evaluation of SARS-CoV-2 IgG antibody reactivity in a multi-racial/ethnic cohort of patients with systemic lupus erythematosus 1206评价多种族/民族系统性红斑狼疮患者的SARS-CoV-2 IgG抗体反应性

1200 - COVID-19 Pub Date : 2021-11-01 DOI: 10.1136/lupus-2021-lupus21century.73

Amit Saxena, Allison Guttmann, M. Masson, Mimi Y Kim, Rebecca H. Haberman, Rochelle Castillo, J. Scher, K. Deonaraine, Alexis J Engel, H. Michael Belmont, Ashira Blazer, Jill P. Buyon, R. Fernandez-Ruiz, P. Izmirly

引用次数: 0

1202 COVID-19 pandemic stressors and psychological distress symptoms in patients with systemic lupus erythematosus and rheumatoid arthritis 1202系统性红斑狼疮和类风湿性关节炎患者的新冠肺炎大流行应激源和心理困扰症状

1200 - COVID-19 Pub Date : 2021-11-01 DOI: 10.1136/lupus-2021-lupus21century.69

D. Costa, É. Boilard, L. Flamand, E. Rollet-Labelle, Jean-Benoît Deville-Stoetzel, L. Bessette, K. Adams, Alexandra Albert, M. Audet, Sonia Lagacé, Charlotte Grondin, Philippe Desaulniers, P. Fortin

{"title":"1202 COVID-19 pandemic stressors and psychological distress symptoms in patients with systemic lupus erythematosus and rheumatoid arthritis","authors":"D. Costa, É. Boilard, L. Flamand, E. Rollet-Labelle, Jean-Benoît Deville-Stoetzel, L. Bessette, K. Adams, Alexandra Albert, M. Audet, Sonia Lagacé, Charlotte Grondin, Philippe Desaulniers, P. Fortin","doi":"10.1136/lupus-2021-lupus21century.69","DOIUrl":"https://doi.org/10.1136/lupus-2021-lupus21century.69","url":null,"abstract":"1202 Table 1Degree of Concerns related to COVID-19 Stressors for Patients with SLE or RACOVID-19 Stressors All Participantsn=97n (%) SLEn=55n (%) RAn=42n (%) Having loved ones who contracts coronavirus 40 (41.2) 28 (50.9) 12 (28.6) Possibility of contracting coronavirus 40 (41.2) 25 (45.5) 15 (35.7) Getting sick from exposure to coronavirus 31 (32) 22 (40) 9 (21.4) Working in a place likely to be exposed to the coronavirus. 26 (26.8) 17 (30.9) 9 (21.4) Possibility of condition worsening or being poorly managed due to changes in medical care 26 (26.8) 15 (27.3) 11 (26.2) Postponement or cancellation of diagnostic and disease monitoring tests 19 (19.6) 10 (18.2) 9 (21.4) Increased responsibilities at home 19 (19.6) 11 (20) 8 (19.0) Difficulty obtaining food, medicine and other essentials 16 (16.5) 9 (16.4) 7 (16.7) Changes in treatments due coronavirus pandemic 15 (15.5) 9 (16.4) 6 (14.3) Postponement or cancellation of medical visits 15 (15.5) 9 (16.4) 6 (14.3) Difficulty obtaining help or social support needed 12 (12.4) 8 (14.5) 4 (9.5) Losing a job or experiencing a drop in income related to the coronavirus pandemic 10 (10.3) 5 (9.1) 5 (11.9) Responses rated on a scale of 0 “not at all” to 4 “extremely” concerned or worried. Responses dichotomized such that a threshold of 2 or higher represent greater concern/worry.ConclusionsStressors related to the COVID-19 pandemic are experienced by an important proportion of patients with SLE and RA and are associated with psychological symptoms, particularly for patients with SLE.","PeriodicalId":263566,"journal":{"name":"1200 - COVID-19","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134448609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

1203 STING/type i interferon pathway activation in patients with perniosis during the COVID–19 pandemic 1203 STING/ i型干扰素途径在2019冠状病毒病大流行期间的激活

1200 - COVID-19 Pub Date : 2021-11-01 DOI: 10.1136/lupus-2021-lupus21century.70

J. An, A. Kalus, Sarah Chung, Brandon Seaton, Ata S. Moshiri, D. Lih, Ying Zheng, H. Krishnamurthy, Xizhang Sun, Lena Tanaka, K. Elkon

{"title":"1203 STING/type i interferon pathway activation in patients with perniosis during the COVID–19 pandemic","authors":"J. An, A. Kalus, Sarah Chung, Brandon Seaton, Ata S. Moshiri, D. Lih, Ying Zheng, H. Krishnamurthy, Xizhang Sun, Lena Tanaka, K. Elkon","doi":"10.1136/lupus-2021-lupus21century.70","DOIUrl":"https://doi.org/10.1136/lupus-2021-lupus21century.70","url":null,"abstract":"1203 Figure 1Clinical appearance of perniosis in study patients showing red and purple papules over several toes some with near blisters (A and B). MxA staining of skin from perniosis lesion (D) showing lymphocytic inflammation in the dermis with perivascular and periadenexal inflammation. There is prominent MxA staining in the epidermis, dermal inflammatory infiltrate and in the superficial endothelial cells indicating interferon activation in skin. This is compared to no MxA staining in normal skin (C).[Figure omitted. See PDF]ConclusionsThe frequency of perniosis during the COVID pandemic, suggests a relationship between these two conditions although direct evidence of COVID-19 infection has been limited. We observed a trend toward higher IFN-b gene expression in PBMC as well as higher phospho-STING protein expression in CD14 monocytes and, most significantly, strong expression of MxA in skin. While the small number of patients preclude a definitive explanation, our data suggest that COVID associated perniosis is an interferonopathy. We propose that acute, transient COVID infection led to monocyte activation, IFN-I production and damage to the small vessels, likely aggravated by cold exposure.","PeriodicalId":263566,"journal":{"name":"1200 - COVID-19","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132728993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

1205 COVID-19 vaccine beliefs amongst individuals living with lupus 1205狼疮患者对COVID-19疫苗的看法

1200 - COVID-19 Pub Date : 2021-11-01 DOI: 10.1136/lupus-2021-lupus21century.72

R. Sadun, A. Eudy, Jennifer L Rogers, K. Sun, Karissa Grier, E. Scarlett, Mithu Maheswaranathan, Lisa G. Criscione-Schreiber, J. Doss, M. Clowse

引用次数: 1

1201 Flares after SARS-Cov-2 vaccination in patients with systemic lupus erythematosus 1201例系统性红斑狼疮患者接种SARS-Cov-2疫苗后的耀斑

1200 - COVID-19 Pub Date : 2021-11-01 DOI: 10.1136/lupus-2021-lupus21century.68

M. Barbhaiya, Jonah M. Levine, Caroline H. Siegel, V. Bykerk, D. Jannat-Khah, L. Mandl

引用次数: 2