发布求助
文献互助 智能选刊 最新文献

Pancreatic Cancer [Working Title]最新文献

筛选
英文 中文
Advance in Pancreatic Cancer Diagnosis and Therapy 胰腺癌诊断与治疗进展
Pancreatic Cancer [Working Title] Pub Date : 2020-11-03 DOI: 10.5772/intechopen.94413
Xiaojie Cai, Jie Gao, Yanfang Liu, Ming Wang, Qiulian Ma, A. Gong, Dongqing Wang, Haitao Zhu
{"title":"Advance in Pancreatic Cancer Diagnosis and Therapy","authors":"Xiaojie Cai, Jie Gao, Yanfang Liu, Ming Wang, Qiulian Ma, A. Gong, Dongqing Wang, Haitao Zhu","doi":"10.5772/intechopen.94413","DOIUrl":"https://doi.org/10.5772/intechopen.94413","url":null,"abstract":"Pancreatic carcinoma is the fourth leading cause of cancer death in the word wild. Although the advance in treatment this disease, the 5-years survival rate is still rather low. In the recent year, many new therapy and treatment avenues have been developed for pancreatic cancer. In this chapter, we mainly focus on the following aspect: 1) the treatment modality in pancreatic cancer, including chemotherapy, radiotherapy, and immunotherapy; 2) the mechanism of pancreatic cancer treatment resistance, especially in cancer stem cells and tumor microenvironment; 3) the diagnosis tools in pancreatic cancer, including serum markers, imaging methods and endoscopic ultrasonography. Novel molecular probes based on the nanotechnology in the diagnosis of pancreatic cancer are also discussed.","PeriodicalId":261813,"journal":{"name":"Pancreatic Cancer [Working Title]","volume":"388 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123512434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current Systemic Treatment Options for Metastatic and Unresectable Pancreatic Cancer 目前转移性和不可切除胰腺癌的全身治疗方案
Pancreatic Cancer [Working Title] Pub Date : 2020-10-05 DOI: 10.5772/intechopen.93225
C. Caglevic, M. Mahave, C. Sanhueza, L. Ubillos
{"title":"Current Systemic Treatment Options for Metastatic and Unresectable Pancreatic Cancer","authors":"C. Caglevic, M. Mahave, C. Sanhueza, L. Ubillos","doi":"10.5772/intechopen.93225","DOIUrl":"https://doi.org/10.5772/intechopen.93225","url":null,"abstract":"Metastatic and local advanced unresectable pancreatic cancers are lethal conditions that always carry a poor prognosis with rare exceptions. Currently, the mainstay of therapy is cytotoxic chemotherapy plus best supportive care. First-line therapy for patients with a good performance status includes FOLFIRINOX or gemcitabine plus nab-paclitaxel regimens. Patients carrying a deleterious germline BRCA mutation can be treated with maintenance olaparib after FOLFIRINOX. Patients with a poor performance status, but still fit enough for chemotherapy, may be treated with single agent gemcitabine. Second-line therapy will depend on previous therapy and current performance status. Options for patients treated with gemcitabine-based regimens are 5-fluorouracil plus leucovorin plus either nanoliposomal irinotecan, irinotecan or oxaliplatin. Patients that were treated with first line FOLFIRINOX may benefit from a gemcitabine-based chemotherapy, but evidence from randomized trials is lacking. Other options like immunotherapy and targeted therapies yield benefit only in very selected cases, and it is still an area of research.","PeriodicalId":261813,"journal":{"name":"Pancreatic Cancer [Working Title]","volume":"8 11","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132512554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Computer Assistance in the Minimally Invasive Ablation Treatment of Pancreatic Cancer 计算机辅助胰腺癌微创消融治疗
Pancreatic Cancer [Working Title] Pub Date : 2020-07-15 DOI: 10.5772/intechopen.93226
Benjamin Eigl, A. Andreou, M. Peterhans, S. Weber, B. Gloor
{"title":"Computer Assistance in the Minimally Invasive Ablation Treatment of Pancreatic Cancer","authors":"Benjamin Eigl, A. Andreou, M. Peterhans, S. Weber, B. Gloor","doi":"10.5772/intechopen.93226","DOIUrl":"https://doi.org/10.5772/intechopen.93226","url":null,"abstract":"The insertion of ablation needles towards pancreatic tumors demands excellent anatomical knowledge and interdisciplinary skills from the medical professional. While the placement of a single needle next to the structures at risk surrounding the pancreas is considered a challenging task, irreversible electroporation requires multiple needles to be placed in parallel at a specific location. Minimally invasive procedures complicate the already ambitious procedure, yet the ablation method bears potential to increase the overall survival for patients with locally advanced pancreatic cancer. Current studies require more clinical evidence regarding the efficacy of irreversible electroporation in pancreatic cancer by means of randomized controlled, multicenter trials. However, the ablation treatment is currently applied in expert centers only, which is due to the complex task of the needle placement. Computer-assisted surgery has shown its potential in different fields of applications to improve the targeting of diseased tissue and the confidence of the medical professional. The application of computer-assisted needle navigation for pancreatic cancer ablation holds the prospect to make the procedure more reproducible and safer.","PeriodicalId":261813,"journal":{"name":"Pancreatic Cancer [Working Title]","volume":"33 2 Pt 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116531879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信