{"title":"Effect of ultrasound-guided brachial plexus and superficial cervical plexus nerve block anesthesia in patients with middle clavicle fractures","authors":"Jun Liu","doi":"10.23977/medbm.2023.010102","DOIUrl":"https://doi.org/10.23977/medbm.2023.010102","url":null,"abstract":": To investigate the value of ultrasound-guided brachial plexus combined with superficial cervical plexus nerve block anesthesia in the surgery of patients with mid-clavicular fracture. Eighty patients with mid-clavicular fractures admitted to a hospital from January 2020 to December 2022 were selected for the study, and they were randomly divided into a control group and a study group, 40 patients in each group, and both groups were treated with internal fixation of clavicular fractures. The anesthetic effect and anesthesia, heart rate and blood pressure at different time points, serum adrenocorticotropic hormone (ACTH) and cortisol (Cor) levels before surgery and at the time of fracture reduction, and postoperative complications were compared between the two groups. The anesthetic effect of the study group was significantly better than that of the control group ( P <0.05); the onset of anesthesia and sensory block were longer ( P <0.05) and the recovery time of sensation was shorter ( P <0.05) in the control group than in the study group; there was no significant difference between the heart rate and blood pressure of the two groups before anesthesia ( P >0.05), and the heart rate and blood pressure of the control group at the time of stripping the periosteum, at the end of surgery and at 10 min after surgery were significantly different. The heart rate and blood pressure of the control group were higher than those of the study group at the time of stripping the periosteum, at the end of surgery and 10 min after surgery ( P <0.05); before surgery, there was no significant difference in ACTH and Cor levels between the two groups ( P >0.05), and after fracture reduction, ACTH and Cor levels increased in both groups, and the control group was higher than the study group","PeriodicalId":259121,"journal":{"name":"MEDS Basic Medicine","volume":"96 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115784121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A case of acute generalized exanthematous pustulosis caused by butylphthalide sodium chloride injection and review of the literature","authors":"Hui Wang, Fangfang Dong, Chan Zhao","doi":"10.23977/medbm.2023.010107","DOIUrl":"https://doi.org/10.23977/medbm.2023.010107","url":null,"abstract":": A 73-year-old female patient with small artery occlusive cerebral infarction was given atorvastatin calcium tablets 20 mg orally once/d, aspirin enteric-coated tablets 100 mg orally once/d, Clopidogrel bisulfate tablets 75 mg orally once/d, Citicoline sodium tablets 200 mg orally three times/d, and butylphthalide and sodium chloride injection 100 ml intravenously twice/d.nine days later, the body appeared scattered erythema with sharply demarcated and different sizes, which was considered to be caused by butyl phthalein sodium chloride injection or Clopidogrel bisulfate tablets. This drug was discontinued and other drugs continued to be used. Three days later, the body temperature began to rise, reaching over 38 ℃. On the fourth day, the body temperature continued to rise, presenting classical skin lesions: Based on generalized diffuse, edematous erythema, there were dense, superficial, non-follicular yellow-white pustules, some of which formed pus lakes. After a consultation with a dermatologist, the patient was diagnosed with acute generalized exanthematous pustulosis, and treated with intravenous drips of methylprednisolone, human immunoglobin and human albumin, etc. After 3 weeks of symptomatic treatment, the skin lesions were cured. Clopidogrel bisulfate tablets were re-applied after specialist evaluation and no similar lesions occurred.","PeriodicalId":259121,"journal":{"name":"MEDS Basic Medicine","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132843131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Research Progress of Urogenic Stem Cells and Exosomes in Chronic Kidney Disease","authors":"Yuanmin Zhang, Sheng Dong","doi":"10.23977/medbm.2023.010106","DOIUrl":"https://doi.org/10.23977/medbm.2023.010106","url":null,"abstract":": Chronic kidney disease (CKD) is a chronic metabolic disease with renal function injury or glomerular filtration rate <60% caused by a variety of factors. Due to the powerful compensatory function of the kidney, the onset of the disease is hidden, and if it cannot be detected and intervened in time, it can eventually progress to end-stage renal disease. At this time, alternative drugs such as dialysis and kidney transplantation can be used to maintain life. Urine-derivedstemceslls (USUs) are stem cells obtained from human blood with very high expansion function and multi-differentiation potential, and have the characteristics of unlimited source, non-invasive and self-derived culture. Many scientific studies have shown that USCs also has very important physiological and pathological effects in the fields of cell inflammatory response, cell apoptosis and cellular oxidative stress. Therefore, the search for potential biomarkers of chronic kidney disease has become an urgent problem. In this paper, the origin, isolation and culture of urogenic stem cells, their application in chronic kidney disease and the research progress of exosomes were reviewed.","PeriodicalId":259121,"journal":{"name":"MEDS Basic Medicine","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124671564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Progress in the application of intestinal flora in the treatment of diabetes","authors":"Ruohan Wen, Xingshuo Huang, Houru Liu, De-qing Yu","doi":"10.23977/medbm.2023.010104","DOIUrl":"https://doi.org/10.23977/medbm.2023.010104","url":null,"abstract":": Intestinal flora is closely related to human health, and its imbalance is related to the occurrence and development of many diseases, such as intestinal inflammation, intestinal tumors, obesity, diabetes, autoimmune diseases, etc. It has a great effect on host nutrition, exogenous and drug metabolism, and the interaction between intestinal flora and host ensures the health of body function, and also affects the participation in various physiological activities and functions of the body.","PeriodicalId":259121,"journal":{"name":"MEDS Basic Medicine","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124739778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Advances in the Pathogenesis of Knee Osteoarthritis and the Application of Chinese and Western Medicine Treatment","authors":"Baotao Sun, J. Dang","doi":"10.23977/medbm.2023.010103","DOIUrl":"https://doi.org/10.23977/medbm.2023.010103","url":null,"abstract":": Osteoarthritis of the knee is a common chronic joint disease in clinical practice. The disease is common in middle-aged and elderly people, and patients are often accompanied by pain and discomfort, activity limitation, and in severe cases, even deformity of the knee joint, which seriously reduces the quality of life of patients and causes great pain to them. In recent years, the incidence of osteoarthritis of the knee has increased with the improvement of living conditions and lifestyle changes, and the increase in life expectancy. This paper reviews the clinical research progress of Chinese and Western medicine treatment of knee osteoarthritis at this stage.","PeriodicalId":259121,"journal":{"name":"MEDS Basic Medicine","volume":"s3-35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130147130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Current Situation and Therapeutic Principles of Dance/Movement Therapy in China","authors":"Shi Hang","doi":"10.23977/medbm.2023.010101","DOIUrl":"https://doi.org/10.23977/medbm.2023.010101","url":null,"abstract":": Dance/Movement Therapy (DMT), born at the intersection of the development of dance art and psychology, has become relatively mature in Western countries such as the United States, the United Kingdom, and Germany. While in China, the profession is still in a period of vigorous development after a long period of understanding and introduction to the theoretical and practical aspects of Western DMT. This paper mainly analyzes the current development status of DMT in China","PeriodicalId":259121,"journal":{"name":"MEDS Basic Medicine","volume":"76 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121019203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Physiological Study of Microglial Cell Polarization","authors":"Jiayue Sun","doi":"10.23977/medbm.2023.010105","DOIUrl":"https://doi.org/10.23977/medbm.2023.010105","url":null,"abstract":": Microglia play an important role in the course of ICH (Intracerebral Hemorr-Hage), and its activation degree, phenotypic polarization, hematoma clearance mechanism and its interaction with nerve cells are hot topics in ICH research at present. In this paper, ICH was taken as an example, and the research progress of microglia function changes after ICH was summarized, and the phenotypic transformation of microglia was summarized. The nitrite peroxide produced by M1 microglia in the immune reaction externalizes the phosphoacyl serine residues outside the nerve cells and sends out phagocytic signals, so that microglia can play the role of brain phagocytosis and cause nerve cell damage. The expression of pro-inflammatory microglia (M1 type) and repair microglia (M2 type) increased, and the microglia were mainly M1 type. In addition, the expression of M1 microglia in ICH 72 h group was lower than that in ICH 24 h group, while the expression of M2 microglia in ICH72 h group was higher than that in ICH 24 h group. Compared with Sham group, the increasing trend of M1 microglia expression after ICH is consistent with the increasing trend of TLR4/NF-κ B.","PeriodicalId":259121,"journal":{"name":"MEDS Basic Medicine","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122594821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}