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2022 APS Special Issue最新文献

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Strategies to reduce the wearing time of cabotegravir sodium dissolving microarray pacthes by facilitating fast tip detachment from the baseplate 通过促进针尖与基板的快速分离来减少卡替格拉韦钠溶微阵列贴片磨损时间的策略
2022 APS Special Issue Pub Date : 2022-11-04 DOI: 10.5920/bjpharm.1083
Fabiana Volpe-Zanutto, Lalitkumar V. Kumar, I. Tekko, C. Jarrahian, R. Donnelly
{"title":"Strategies to reduce the wearing time of cabotegravir sodium dissolving microarray pacthes by facilitating fast tip detachment from the baseplate","authors":"Fabiana Volpe-Zanutto, Lalitkumar V. Kumar, I. Tekko, C. Jarrahian, R. Donnelly","doi":"10.5920/bjpharm.1083","DOIUrl":"https://doi.org/10.5920/bjpharm.1083","url":null,"abstract":"Dissolvingmicroarray patches (DMAP) contain micron-scale projections and are usually madefrom biocompatible water-soluble polymers containing a high amount of drug intheir tips, to be delivered through the skin layers. The challenge regarding DMAPis the detachment of the tips from the baseplate.  This impacts the wearing time, the deliveryefficiency of the skin, and patient compliance. In our previous work, wereported the delivery of cabotegravir sodium (CAB Na), an anti-HIV drug, necessittingthe wearing time of more than 1 hour [1].Herein we developed strategies to reduce the wearing time of DMAP containingcabotegravir sodium from hours to 10 minutes by facilitating tip detachmentfrom the baseplate. ","PeriodicalId":239152,"journal":{"name":"2022 APS Special Issue","volume":"73 3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130154623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Challenges and considerations of automated agglomeration detection method development with image analysis in dissolution testing 溶出度检测中图像分析自动结块检测方法开发的挑战与思考
2022 APS Special Issue Pub Date : 2022-11-03 DOI: 10.5920/bjpharm.1139
Alexandra Taseva, T. Persoons, D. D'Arcy
{"title":"Challenges and considerations of automated agglomeration detection method development with image analysis in dissolution testing","authors":"Alexandra Taseva, T. Persoons, D. D'Arcy","doi":"10.5920/bjpharm.1139","DOIUrl":"https://doi.org/10.5920/bjpharm.1139","url":null,"abstract":"Dissolution testing is widely used during all stages of drug development. The potential to develop an imaging analysis method to automatically detect agglomerations during dissolution testing has recently been explored. The stages of the method development were manual observation of pre-recorded videos from the dissolution testing, choice of parameters for agglomerate identification and 2-stage method validation (internal and external). This work presents the two main challenges faced during the agglomeration identification method (AIM) development a) attaining an optimal number of particle detections in a video frame and b) discerning different objects (e.g., air bubbles, single particles and agglomerates) based on their specifications.","PeriodicalId":239152,"journal":{"name":"2022 APS Special Issue","volume":"154 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122828061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing the effect of moderately increasing medium viscosity on the intrinsic dissolution rate and diffusion coefficient of ibuprofen particles 适度增加介质粘度对布洛芬颗粒固有溶出速率和扩散系数的影响
2022 APS Special Issue Pub Date : 2022-11-03 DOI: 10.5920/bjpharm.1130
Marina Navas Bachiller, T. Persoons, A. Healy, D. D'Arcy
{"title":"Assessing the effect of moderately increasing medium viscosity on the intrinsic dissolution rate and diffusion coefficient of ibuprofen particles","authors":"Marina Navas Bachiller, T. Persoons, A. Healy, D. D'Arcy","doi":"10.5920/bjpharm.1130","DOIUrl":"https://doi.org/10.5920/bjpharm.1130","url":null,"abstract":"This study investigated the effects of moderately increasing medium viscosity through two viscosity enhancing agents (VEA) (HPMC and sucrose) on the intrinsic dissolution of a BCS class II drug (ibuprofen). The differences in intrinsic dissolution were characterized through the estimation of a diffusion coefficient (D) of ibuprofen in different media with the Levich equation. Increasing viscosity decreased the intrinsic dissolution rate of ibuprofen with both VEAs. The calculated D from intrinsic dissolution data overestimated the experimental value, but the results suggest that intrinsic dissolution could be used as a tool to estimate a relative change in D in different viscosities. ","PeriodicalId":239152,"journal":{"name":"2022 APS Special Issue","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131156320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Pharmaceutical Science in a post-COVID-19 world: The 13th APS PharmSci International Conference 后covid -19时代的制药科学:第13届APS PharmSci国际会议
2022 APS Special Issue Pub Date : 2022-11-01 DOI: 10.5920/bjpharm.1268
Hannah Batchelor
{"title":"Pharmaceutical Science in a post-COVID-19 world: The 13th APS PharmSci International Conference","authors":"Hannah Batchelor","doi":"10.5920/bjpharm.1268","DOIUrl":"https://doi.org/10.5920/bjpharm.1268","url":null,"abstract":"The 13th APS PharmSciInternational Conference was held in Belfast between the 7th and 9th September 2022 at the city’s landmark Europa Hotel. The event, the first face-to-face APS meeting since Greenwich in 2019, attracted 365 delegates of more than 20 nationalities. A key theme running through the conference was how innovation and teamwork in the pharmaceutical sciences, often across international boundaries, continue to drive the recovery of patients, healthcare organizations, the economy, and society to overcome the deleterious effects of the COVID-19pandemic.","PeriodicalId":239152,"journal":{"name":"2022 APS Special Issue","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123546021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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