Biochemical Testing - Clinical Correlation and Diagnosis最新文献

Serum Protein Electrophoresis and Its Clinical Applications 血清蛋白电泳及其临床应用

Biochemical Testing - Clinical Correlation and Diagnosis Pub Date : 2019-10-11 DOI: 10.5772/intechopen.88367

Satish Ramanathan, C. Srinivas

引用次数: 2

Advancement in Analytical and Bioanalytical Techniques as a Boon to Medical Sciences 分析和生物分析技术的进步对医学科学的好处

Biochemical Testing - Clinical Correlation and Diagnosis Pub Date : 2019-06-14 DOI: 10.5772/INTECHOPEN.80279

Khushaboo Pandey, O. Mishra

{"title":"Advancement in Analytical and Bioanalytical Techniques as a Boon to Medical Sciences","authors":"Khushaboo Pandey, O. Mishra","doi":"10.5772/INTECHOPEN.80279","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.80279","url":null,"abstract":"The most important objectives frequently found in analytical and bioanalytical chemistry involve advancement of analytical techniques and its application to relevant medical/clinical problems. Keeping in view to these aspects, the present chapter is primarily focused on the development of advanced analytical techniques applied in the medical field. For example, N-acetyl-beta-D-glucosaminidase (NAG) enzyme is a specific biomarker of acute kidney injury. A biomarker is an entity that is purposely measured and estimated as an indicator of normal biological process, pathogenic process, or pharmacological responses to a therapeutic intervention. Hence, successive measurements of urinary NAG may enhance its clinical use as an indicator of ongoing tubular injury. Hence, in order to obtain information for selective monitoring of biomarker, the development of a practical and valid analytical method is important. Experimentation is driven by the need to know more about the medical effects and safety features of the biologically active analyte. It is therefore more important to evaluate the information that is already available for that particular analyte and to quantify the level of uncertainty for the proposed technique.","PeriodicalId":237039,"journal":{"name":"Biochemical Testing - Clinical Correlation and Diagnosis","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132689726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Resource-Based View of Laboratory Management: Tissue Bank ATMP Production as a Model 实验室管理的资源观:以组织库ATMP生产为模型

Biochemical Testing - Clinical Correlation and Diagnosis Pub Date : 2019-05-31 DOI: 10.5772/INTECHOPEN.86561

Wojciech Smętek, Jacek Węgrzyk, A. Klama-Baryła, W. Łabuś, M. Kraut, Michał Szapski, M. Nowak, D. Kitala

引用次数: 1

Urinary Iodine: Biomarker for Population Iodine Nutrition 尿碘:人群碘营养的生物标志物

Biochemical Testing - Clinical Correlation and Diagnosis Pub Date : 2019-04-17 DOI: 10.5772/INTECHOPEN.84969

Husniza Hussain, Rusidah Selamat, L. K. Kuay, F. Zain, M. Y. Jalaludin

{"title":"Urinary Iodine: Biomarker for Population Iodine Nutrition","authors":"Husniza Hussain, Rusidah Selamat, L. K. Kuay, F. Zain, M. Y. Jalaludin","doi":"10.5772/INTECHOPEN.84969","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.84969","url":null,"abstract":"Many reports or manuals had focused on the implementation of iodine deficiency disorder (IDD) elimination programme from the point of view of the programme managers. In this chapter, we will focus on the importance of urinary iodine testing, its related diagnosis and further biomarker testing suggested for further diagnosis related to thyroid health. This chapter will be relevant for the respondents to the monitoring programme, particularly the 8–10-year-old schoolchildren and pregnant women, i.e., the vulnerable targeted groups from either the iodine-deficient areas or the Universal Salt Iodization (USI) gazetted areas. USI has been proposed by the World Health Organization (WHO) as the most cost-effective programme to eliminate IDD, and it is also a way to increase the intelligent quotient (IQ) of the world population for the future. This chapter had been laid out so that the readers will know briefly the rationale behind the testing of urinary iodine among schoolchildren and pregnant women under the implementation of the USI programmes in their countries and their benefits, especially the utilisation of urinary iodine as the biomarker to por-tray the population iodine status. Diagnosis including iodine-induced thyroid diseases and further biomarkers measurement besides urinary iodine is also discussed briefly.","PeriodicalId":237039,"journal":{"name":"Biochemical Testing - Clinical Correlation and Diagnosis","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133109344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Amino Acids Profiling for the Diagnosis of Metabolic Disorders 氨基酸谱分析诊断代谢紊乱

Biochemical Testing - Clinical Correlation and Diagnosis Pub Date : 2019-03-08 DOI: 10.5772/INTECHOPEN.84672

Yana Sandlers

引用次数: 9

ZIKV Diagnostics: Current Scenario and Future Directions ZIKV诊断:目前的情况和未来的方向

Biochemical Testing - Clinical Correlation and Diagnosis Pub Date : 2018-11-29 DOI: 10.5772/INTECHOPEN.82373

Zilton F. M. Vasconcelos, R. Azevedo, A. Zin, L. Neves, D. Cunha

{"title":"ZIKV Diagnostics: Current Scenario and Future Directions","authors":"Zilton F. M. Vasconcelos, R. Azevedo, A. Zin, L. Neves, D. Cunha","doi":"10.5772/INTECHOPEN.82373","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.82373","url":null,"abstract":"Since the discovery of the Zika virus in Uganda in 1947, diagnostic challenges remain, especially when we take into account the epidemiological context of the surveyed population. Genetic similarities with other flavivirus are responsible for cross-reac tivity during serological evaluation that would often be the only resources to confirm the infection in asymptomatic cases or samples collected after the short window of viral RNA detection. The importance of Zika virus infection diagnosis is undoubtedly useful for pregnant women. This statement became evident after 2015 Brazil’s Zika outbreak when a significant increase in cases of newborn with microcephaly was observed. Reverse transcriptase real-time PCR is the most reliable tool for Zika virus infection diagnosis. It detects viral RNA in both biological fluids and tissues and contributes to clinical case classification for initial description of developmental changes observed in neonates exposed congenitally to Zika virus. In conclusion, advances in serological diagnostic are urgent. The safest pathway for these studies requires laborious, subjective, and low throughput PRNT evaluations. Consequently, critical public health questions remain unanswered: how serum prevalent is the general population and pregnant women; can we define risk for congenital Zika syndrome (CZS) and Guillain-Barré syndrome; and how to assess vaccine efficacy and long-term protection.","PeriodicalId":237039,"journal":{"name":"Biochemical Testing - Clinical Correlation and Diagnosis","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125220909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Pre-Analytical Within-Laboratory Evacuated Blood-Collection Tube Quality Evaluation 分析前实验室内真空采血管质量评价

Biochemical Testing - Clinical Correlation and Diagnosis Pub Date : 2018-11-05 DOI: 10.5772/INTECHOPEN.80685

N. Gros

引用次数: 1