Hematology, Blood Transfusion and Disorders最新文献

Beware Of Temperature Changes: A Case Report Of Paroxysmal Cold Haemoglobinuria 注意温度变化:阵发性寒性血红蛋白尿1例报告

Hematology, Blood Transfusion and Disorders Pub Date : 2019-11-08 DOI: 10.24966/hbtd-2999/100021

{"title":"Beware Of Temperature Changes: A Case Report Of Paroxysmal Cold Haemoglobinuria","authors":"","doi":"10.24966/hbtd-2999/100021","DOIUrl":"https://doi.org/10.24966/hbtd-2999/100021","url":null,"abstract":"Paroxysmal cold haemoglobinuria is an immune haemolytic syndrome characterized by the presence of autoantibodies reactive against specific red blood cell antigens. At low temperatures, these antibodies and the complement fix to the red blood cells, leading to haemolysis upon warming up. We present the case of a twenty-one months old male child, who presented with a six-day history of malaise, productive cough and fe -ver, already medicated with amoxicillin and clavulanic acid two days before. On physical examination, the child was prostrated, severe ly pale, but with no hemodynamic instability or difficulty breathing. Blood tests revealed the presence of severe anaemia (Hb 5.4 g/dL), leucocytosis (19.90 x 10 9 /L), without immature cells in the blood film; reticulocytosis (89.7 x 10 6 /L) and evidence of hemolysis (haptoglo-bin <8 mg/dL; LDH 1328 UI/L; bilirubin 1 mg/dL and unconjugated bilirubin 0.6 mg/dL), C-reactive-protein 56.7 mg/L. He received a transfusion of red blood cells, initiated treatment with oral clarithro mycin and reinforced the rewarming of the extremities with good re - sults (Hb 9.6 g/dL). Regarding serological investigation, the results revealed a positive IgM for Mycoplasma pneumoniae ; positive Direct Antiglobulin Test with specificity for CD3, and positive Donath Land steiner test, leading to the diagnosis. This case report represents a syndrome that even though rare, is important to bear in mind when facing a case of severe haemolysis. Despite the favorable outcome, additional follow-up must be placed in outpatient setting, with periodic clinical and laboratorial revalua -tions.","PeriodicalId":236918,"journal":{"name":"Hematology, Blood Transfusion and Disorders","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115610308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Correlations Between Aging, Oxidative Stress, Micronutrient Deficiencies, Pollutant Metal-Toxicity And Increased Serum Gamma-Glutamyl Transferase (GGT) Among Chronic Myeloid Leukemia Congolese 慢性髓性白血病刚果人衰老、氧化应激、微量营养素缺乏、污染物金属毒性和血清γ -谷氨酰转移酶(GGT)升高的相关性

Hematology, Blood Transfusion and Disorders Pub Date : 2019-11-08 DOI: 10.24966/hbtd-2999/100024

B. Longo-Mbenza

引用次数: 1

Perioperative And Postoperative Management In Patients With Alpha-2-Antiplasmin Deficiency: A Case Study Of 67-Year-Old Male Undergoing Operative Distal Femur Repair α -2抗纤溶酶缺乏患者的围手术期和术后处理:67岁男性股骨远端手术修复病例研究

Hematology, Blood Transfusion and Disorders Pub Date : 2019-11-08 DOI: 10.24966/hbtd-2999/100023

G. Monohan

引用次数: 0

Screening For Anaemia At Different Phases Of The Menstrual Cycle Among Female Students In A Nigerian University 尼日利亚一所大学女学生在月经周期不同阶段的贫血筛查

Hematology, Blood Transfusion and Disorders Pub Date : 2019-11-08 DOI: 10.24966/hbtd-2999/100022

M. Lugos

引用次数: 0

Vitamin E Status and Total Body Water in Children and Adolescents with Sickle Cell Anemia 儿童和青少年镰状细胞性贫血患者的维生素E水平和全身水分

Hematology, Blood Transfusion and Disorders Pub Date : 2018-07-24 DOI: 10.24966/hbtd-2999/100019

R. Williams-Hooker

{"title":"Vitamin E Status and Total Body Water in Children and Adolescents with Sickle Cell Anemia","authors":"R. Williams-Hooker","doi":"10.24966/hbtd-2999/100019","DOIUrl":"https://doi.org/10.24966/hbtd-2999/100019","url":null,"abstract":"Sickle Cell Disease (SCD) is a genetic disorder caused by a Hemoglobin gene mutation (HbS), which produces abnormal sickle he- moglobin that causes Red Blood Cells (RBC), to form rigid, sickle or holly-leaf-shaped cells rather than the typical round and flexible shape. These RBC’s are not able to pass through the vessels so less oxygen is transported to tissues, leading to vaso-occlusive pain cri - ses, organ damage, stroke, chronic anemia, decreased quality of life and early death. Nutritional concerns for children with SCD include weight loss and poor growth, delayed puberty, vitamin and mineral deficiencies and fluid imbalance. Several studies have shown that dietary intake falls below recommendations in SCD patients and that plasma levels of certain key vitamins, including vitamin E, are lower than reference values. Children with SCD have low to body water, which could be related, in part, to decreased intake. This study ex - plored vitamin E plasma status, vitamin E and fluid intake, and Total Body Water (TBW) status to determine if any of these variables were low. Each variable was also compared to pain scores to see if there was any correlation. Thirty African American children with SCD (15 female, mean age 12.03) participated in this study. Results showed that patients had decreased vitamin E and fluid intake, decreased corrected plasma vitamin E, and TBW below normal, however none of these factors was associated with pain medications. Further research needs to be conducted with a greater sample size and more pain variables.","PeriodicalId":236918,"journal":{"name":"Hematology, Blood Transfusion and Disorders","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129665888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Idiopathic Thrombocytopenic Purpura (ITP) in the Elderly Over 75 Years: About a Rare Series in the Very Elderly Subjects 特发性血小板减少性紫癜(ITP)在75岁以上的老年人:关于一个罕见的系列在老年受试者

Hematology, Blood Transfusion and Disorders Pub Date : 2018-07-24 DOI: 10.24966/HBTD-2999/100017

A. Zulfiqar

引用次数: 0

Effects of Low-Molecular Heparin on Pregnant Women with Factor V Mutation (GA Genotype) 低分子肝素对GA基因型V因子突变孕妇的影响

Hematology, Blood Transfusion and Disorders Pub Date : 2018-07-24 DOI: 10.24966/HBTD-2999/100020

A. Momot

引用次数: 0

Stem Cell Mobilization with and without Plerixafor: A Comparative Analysis 使用和不使用Plerixafor的干细胞动员:比较分析

Hematology, Blood Transfusion and Disorders Pub Date : 2018-07-24 DOI: 10.24966/HBTD-2999/100018

M. M. Fresen

{"title":"Stem Cell Mobilization with and without Plerixafor: A Comparative Analysis","authors":"M. M. Fresen","doi":"10.24966/HBTD-2999/100018","DOIUrl":"https://doi.org/10.24966/HBTD-2999/100018","url":null,"abstract":"A Abstract Patients scheduled for high-dose chemotherapy who fail to mobilize a sufficient number of hematopoietic stem cells have a poor prognosis. Since 2008 the CXCR4-inhibitor plerixafor is available to improve stem cell collection and to reduce the number of failed mo -bilizers. The of Hodgkin Lymphoma (HD) and Multiple Myeloma (MM) was evaluated (group A). All patients received G-CSF with or without chemotherapy for mobilization. This group was matched by age, sex and diagnosis to 47 proven poor mobilizers receiving plerixafor (group B). In group A, 92.9% diagnosed with NHL and all patients diagnosed with MM and HD gathered more than 2.0 × 10^6 CD34+ cells/kg BW. In group B, 64.3% of the NHL patients, 88.2% of the patients diagnosed with MM and all patients with HD were able to collect the defined minimum of CD34+ cells. In total, 74.5% of poor mobilizing patients who received plerixafor gathered more than 2.0 × 10^6/kg BW CD34+ cells. Transplanted cells engrafted in both cohorts; how- ever, in NHL and MM patients, engraftment of white blood cells and platelets were significant earlier in group A than in group B. In conclusion, only 4.3% of patients failed first mobilization at -tempt. For these limited number of patients plerixafor is a valuable additive.","PeriodicalId":236918,"journal":{"name":"Hematology, Blood Transfusion and Disorders","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133954274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0