Breast Cancer and Breast Reconstruction最新文献

Electrical Impedance Mammography: Screening and Basic Principles 电阻抗乳房x线照相术:筛选和基本原理

Breast Cancer and Breast Reconstruction Pub Date : 2020-04-21 DOI: 10.5772/intechopen.89140

A. Karpov, M. Korotkova, G. Shiferson, E. Kotomina

{"title":"Electrical Impedance Mammography: Screening and Basic Principles","authors":"A. Karpov, M. Korotkova, G. Shiferson, E. Kotomina","doi":"10.5772/intechopen.89140","DOIUrl":"https://doi.org/10.5772/intechopen.89140","url":null,"abstract":"Nowadays, screening uses the method of X-ray mammography for the early diagnosis of breast cancer. However, as a screening method, X-ray mammography has its limitations, such as age, periodicity of screening, ‘dense’ mammary gland and dynamic survey (repeated radiation). In order to overpass these limitations, more advanced alternative methods of breast examination should be used, which would be as effective as the ‘golden standard.’ Characteristics of electroimpedance diagnostics are given. The aim of screening is to detect breast cancer including early breast cancer (tumor size below 1 cm) and to form a survey of high-risk group. In order to reach these aims, the following actions need to be undertaken: search for areas with anomalous conductivity, detection of distorted mammographic scheme and evaluation of age-related electrical conductivity. The application of a scale for age-related breast conductivity with defined percentile limits allows to organize a survey group. Electrical properties of a cancerous tumor differ significantly from those of the surrounding tissues. Statistics of anomalous conductivity in cases of breast cancer is given. The disease development connected with the destruction of epithelial basement membrane is linked with various phenomena occurring in the tumor and the surrounding tissues. Statistics of disrupted mammographic scheme in cases of cancer is given.","PeriodicalId":231374,"journal":{"name":"Breast Cancer and Breast Reconstruction","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127302026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Synthetic Mesh in Immediate Breast Reconstruction 合成网片在乳房即刻重建中的应用

Breast Cancer and Breast Reconstruction Pub Date : 2020-03-04 DOI: 10.5772/intechopen.90884

Susana Gómez-Modet, L. Tejedor

引用次数: 4

Epidemiology and Genetic Susceptibility of Breast and Ovarian Cancer in Sardinian Population 撒丁岛人群乳腺癌和卵巢癌的流行病学和遗传易感性

Breast Cancer and Breast Reconstruction Pub Date : 2020-02-17 DOI: 10.5772/intechopen.90517

G. Palomba, G. Palmieri, A. Cossu, P. Paliogiannis, M. Sini

{"title":"Epidemiology and Genetic Susceptibility of Breast and Ovarian Cancer in Sardinian Population","authors":"G. Palomba, G. Palmieri, A. Cossu, P. Paliogiannis, M. Sini","doi":"10.5772/intechopen.90517","DOIUrl":"https://doi.org/10.5772/intechopen.90517","url":null,"abstract":"The objective of this population-based study is to describe epidemiological and genetic features of breast and ovarian cancer in North Sardinia, Italy. Patients who carry a high-risk mutation in one or both of the BRCA genes (BRCA1 or BRCA2) have a significantly increased risk of developing breast/ovarian cancer (BOC) and other cancers (e.g., prostate cancer in male). Epidemiological data on incidence distribution of breast/ovarian cancer from 2016 to 2019 in North Sardinia are obtained from the local tumor registry and from the cumulative results of 209 genetic testing for BRCA gene mutations performed in all young breast cancer patients and all women (over 50 years) with family history of BOC (total of 164 cases); further, 45 genetic testing is performed, on ovarian cancer patients, at any age. The results provide a different distribution of fraction mutations carried by women and a higher prevalence of the BRCA2 mutation in the north of Sardinia than the entire population and highlight the presence of specific germline mutation associated with the “founder effect” in distinct genetic subgroups reflecting genetic drift. Advances in next-generation sequencing technology, data analysis, and clinical investigation have revolutionized efforts to identify potential targets for BRCA molecular-based therapeutic agents.","PeriodicalId":231374,"journal":{"name":"Breast Cancer and Breast Reconstruction","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115517360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Breast Cancer and BRCA1 and BRCA2 Pathogenic Variants 乳腺癌与BRCA1和BRCA2致病变异

Breast Cancer and Breast Reconstruction Pub Date : 2020-01-20 DOI: 10.5772/intechopen.90926

N. Basu, D. Evans

引用次数: 0

Detection of Breast Cancer in Mammograms through a New Features Technique 通过一种新的特征技术在乳房x光检查中发现乳腺癌

Breast Cancer and Breast Reconstruction Pub Date : 2019-10-29 DOI: 10.5772/intechopen.89062

A. Ebrahim

引用次数: 0

L-Shaped Nipple Reconstruction: A Novel Technique to Improve Patient Satisfaction Outcomes l型乳头重建:一种提高患者满意度的新技术

Breast Cancer and Breast Reconstruction Pub Date : 2019-10-20 DOI: 10.5772/INTECHOPEN.86068

Krishnamurthy Sreedhar Murthy

{"title":"L-Shaped Nipple Reconstruction: A Novel Technique to Improve Patient Satisfaction Outcomes","authors":"Krishnamurthy Sreedhar Murthy","doi":"10.5772/INTECHOPEN.86068","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.86068","url":null,"abstract":"INTRODUCTION Nipple reconstruction is the final stage of breast reconstruction and performed after acceptable breast mound shape and symmetry has been achieved. Here is a description of an original technique of L shaped nipple reconstruction to address issues such as transverse mas-tectomy scar which lies at the Neo nipple position. AIM The objective of this study is to describe an original tech-nique of nipple reconstruction, using a combination of random flap and dermal graft; and also measures patient satisfaction of outco-mes. This original technique is set to overcome challenges of nipple reconstruction such as correct positioning, maintaining adequate projection and creating an almost inconspicuous scar. METHODS 31 patients underwent the L-shaped nipple reconstruction between 2011 and 2016 at our Breast Unit. Complications and outcomes were analysed and compared with 59 patients who underwent traditional CV flap during the same study period (total N=90, i.e., L flap n=31 and CV flap=59). RESULTS There was no statistically significant difference in complication rates between traditional CV flap (9.7%) and L-shaped (13.6%) nipple reconstructions (Fishers exact test p=0.74). In our study cohort undergoing L flap nipple reconstruction, 94% were either pleased or very pleased with their decision to have undergone nipple reconstruction and 93% would either strongly or very strongly recommend it to a friend. CONCLUSIONS The innovative L-shaped nipple reconstruction has positive patient satisfaction out-comes and is a very suitable alternative to traditional nipple reconstruction such as CV flap.","PeriodicalId":231374,"journal":{"name":"Breast Cancer and Breast Reconstruction","volume":"162 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124454881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic Mutation Carriers: Special Considerations for Their Influence on a Modern Breast Reconstruction Practice 基因突变携带者:对现代乳房再造实践影响的特殊考虑

Breast Cancer and Breast Reconstruction Pub Date : 2019-07-26 DOI: 10.5772/INTECHOPEN.86795

A. Woodfin, A. Antony

{"title":"Genetic Mutation Carriers: Special Considerations for Their Influence on a Modern Breast Reconstruction Practice","authors":"A. Woodfin, A. Antony","doi":"10.5772/INTECHOPEN.86795","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.86795","url":null,"abstract":"With medical advancement, increasing numbers of genetic variations and mutations are being uncovered that offer greater insight into which patients have a predisposition for the development of breast cancer. Reasonable management for these patients includes high-risk surveillance, medical prophylaxis, or bilateral prophylactic mastectomy with immediate reconstruction which is becoming increasingly popular. However, this cohort of patients differs from the average breast cancer patient in that they are typically younger and may have distinct reconstructive objectives for their outcomes. This chapter considers this unique and expanding population, as well as their expectations for surgical outcomes both aesthetically and oncologically. We will discuss the evolving role of social media in this population, with patient to patient virtual information sharing and how this may impact patient referrals in a manner diverging from traditional hospital-based patterns. Furthermore, we discuss how practices in which cutting-edge and novel surgical treatments are available, such as pre-pectoral and single stage reconstruction, and that incorporate team collaboration with the surgical oncologist to deliver aesthetically pleasing results with nipple sparing mastectomy and concealed scars may ultimately be attractive to genetic mutation carriers concerned not only with risk reduction but also post-operative aesthetics.","PeriodicalId":231374,"journal":{"name":"Breast Cancer and Breast Reconstruction","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131559308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immediate Breast Reconstruction with Free Autologous Tissue Transfer 自体游离组织移植即刻乳房重建

Breast Cancer and Breast Reconstruction Pub Date : 2019-04-16 DOI: 10.5772/INTECHOPEN.85652

Justin T Zelones, Suzanne Inchauste, D. Nguyen

引用次数: 0

Breast Reconstruction with TRAM Flap TRAM皮瓣乳房再造

Breast Cancer and Breast Reconstruction Pub Date : 2019-04-09 DOI: 10.5772/INTECHOPEN.85443

E. Karacaoglu

引用次数: 0