Therapeutic research最新文献

筛选
英文 中文
Efficacy and Gastrin Levels in Gastroesophageal Reflux Disease Patients Treated with Esomeprazole Following a Potassium‒competitive Acid Blocker 胃食管反流病患者在服用钾竞争酸阻滞剂后应用埃索美拉唑治疗的疗效和胃泌素水平
Therapeutic research Pub Date : 2019-01-01 DOI: 10.35248/2157-7560.21.S13.004
S. Ishihara
{"title":"Efficacy and Gastrin Levels in Gastroesophageal Reflux Disease Patients Treated with Esomeprazole Following a Potassium‒competitive Acid Blocker","authors":"S. Ishihara","doi":"10.35248/2157-7560.21.S13.004","DOIUrl":"https://doi.org/10.35248/2157-7560.21.S13.004","url":null,"abstract":"Background:Changing a drug from a potassium‒competitive acid blocker(P‒CAB) to a proton pump inhibitor(PPI)is one of the treatment options for long‒term management of gastroesophageal reflux disease(GERD). GERD symptoms and serum gastrin levels were investigated in reflux esophagitis(RE)patients who switched from potassium‒competitive acid blocker to esomeprazole. Methods:Esomeprazole 20 mg was orally administered to RE patients who had been treated with vonoprazan 20 mg once daily for more than 4 weeks. Primary endpoint was changes in the total scores at Week 4 based on the Frequency Scale for the Symptoms of Gastroesophageal Reflux Disease(FSSG)questionnaire. The secondary endpoints were changes in the reflux scores, motility scores, and total scores evaluated based on the FSSG questionnaire, changes in serum gastrin levels, and tolerability.Results:In 25 patients with mean age of 60.5 years, median FSSG total score demonstrated a significant decrease both at Week 2(p<0.05)and Week 4(p<0.01). Median FSSG reflux score demonstrated a significant decrease both at Week 2(p<0.01)and Week 4(p<0.001). Median FSSG motility scores showed no statistical significance at any time. Median serum gastrin level significantly decreased from 755 pg/mL at baseline to 309 pg/mL at Week 4(p<0.01).Conclusion:Treatment with esomeprazole in patients with GERD was suggested to be a useful option both in management of GERD symptom and serum gastrin level.","PeriodicalId":23046,"journal":{"name":"Therapeutic research","volume":"40 1","pages":"817-823"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69973031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
消化器症状を有する患者に対するQOL問診票 「出雲スケール」の症状の変化に対する反応性の検討 针对消化系统症状患者的QOL问诊表对“出云标度”症状变化的反应性讨论
Therapeutic research Pub Date : 2009-01-01 DOI: 10.1007/978-94-007-0753-5_103325
他 古田賢司
{"title":"消化器症状を有する患者に対するQOL問診票 「出雲スケール」の症状の変化に対する反応性の検討","authors":"他 古田賢司","doi":"10.1007/978-94-007-0753-5_103325","DOIUrl":"https://doi.org/10.1007/978-94-007-0753-5_103325","url":null,"abstract":"","PeriodicalId":23046,"journal":{"name":"Therapeutic research","volume":"30 1","pages":"1651-1658"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51470425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信