Hot Topics in Cardiometabolic Disorders最新文献

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Potential effects of DPP-4 inhibitors on cardiovascular disease DPP-4抑制剂对心血管疾病的潜在影响
Hot Topics in Cardiometabolic Disorders Pub Date : 1900-01-01 DOI: 10.4147/HTCD-100217
V. Fonseca
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引用次数: 1
DPP-4 inhibitors in the treatment of type 2 diabetes DPP-4抑制剂治疗2型糖尿病
Hot Topics in Cardiometabolic Disorders Pub Date : 1900-01-01 DOI: 10.4147/HTCD-100207
M. Gilbert, R. Pratley
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引用次数: 0
Metabolic effects of the ARB telmisartan: potential mechanisms ARB替米沙坦的代谢作用:潜在机制
Hot Topics in Cardiometabolic Disorders Pub Date : 1900-01-01 DOI: 10.4147/HTCD-100111
U. Kintscher
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引用次数: 0
Antidiabetogenic effects of telmisartan: evidence from clinical trials 替米沙坦的抗糖尿病作用:来自临床试验的证据
Hot Topics in Cardiometabolic Disorders Pub Date : 1900-01-01 DOI: 10.4147/HTCD-100115
A. Sierra
{"title":"Antidiabetogenic effects of telmisartan: evidence from clinical trials","authors":"A. Sierra","doi":"10.4147/HTCD-100115","DOIUrl":"https://doi.org/10.4147/HTCD-100115","url":null,"abstract":"","PeriodicalId":229022,"journal":{"name":"Hot Topics in Cardiometabolic Disorders","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121624948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolic effects of telmisartan 替米沙坦的代谢作用
Hot Topics in Cardiometabolic Disorders Pub Date : 1900-01-01 DOI: 10.4147/HTCD-100100
U. Kintscher, A. Sierra
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引用次数: 1
Pitavastatin: an overview 匹伐他汀:概述
Hot Topics in Cardiometabolic Disorders Pub Date : 1900-01-01 DOI: 10.4147/HTCD-110400
M. Farnier, K. Node
{"title":"Pitavastatin: an overview","authors":"M. Farnier, K. Node","doi":"10.4147/HTCD-110400","DOIUrl":"https://doi.org/10.4147/HTCD-110400","url":null,"abstract":"","PeriodicalId":229022,"journal":{"name":"Hot Topics in Cardiometabolic Disorders","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127407924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Familial high-density lipoprotein deficiency states and premature coronary heart disease 家族性高密度脂蛋白缺乏状态与早发冠心病
Hot Topics in Cardiometabolic Disorders Pub Date : 1900-01-01 DOI: 10.4147/HTCD-110307
E. Schaefer, R. Santos, M. Tani, Peter M. Schaefer, B. Asztalos
{"title":"Familial high-density lipoprotein deficiency states and premature coronary heart disease","authors":"E. Schaefer, R. Santos, M. Tani, Peter M. Schaefer, B. Asztalos","doi":"10.4147/HTCD-110307","DOIUrl":"https://doi.org/10.4147/HTCD-110307","url":null,"abstract":"High-density lipoprotein cholesterol (HDL-C) values <40 mg/dL have been shown to be an independent risk factor for coronary heart disease (CHD). Rare genetic disorders associated with marked human HDL deficiency include apolipoprotein A-I (apoA-I) deficiency with undetectable plasma apoA-I, which can be due to defects within the APOA1 gene resulting in lack of apoA-I secretion. Such patients have marked HDL deficiency, normal levels of triglycerides (TGs), and low-density lipoprotein cholesterol (LDL-C), and they can have xanthomas and premature CHD. ApoA-I variants with amino acid substitutions, especially in the region of amino acid residues 50–93 and 170–178, have been associated with amyloidosis. Patients with homozygous Tangier disease have defective cellular cholesterol efflux due to mutations in the adenosine-5′-triphosphate (ATP)-binding cassette transporter A1, detectable plasma apoA-I levels, and only pre-β1 HDL in their plasma. They have decreased LDL-C levels and can develop neuropathy and premature CHD. Patients with lecithin:cholesterol acyltransferase deficiency have both pre-β1 and α4 HDL present in their plasma and develop corneal opacities, anemia, proteinuria, and kidney failure. HDL deficiency has been associated with hypertriglyceridemia, obesity, insulin resistance, and diabetes. Common familial disorders associated with premature CHD and low HDL are: (1) dyslipidemia, seen in 15% of families, (2) combined hyperlipidemia, seen in 14% of families, and (3) hypoalphalipoproteinemia, seen in 4% of families. A common feature of all these disorders associated with premature CHD is a marked deficiency of very large α1 HDL. Niacin is currently the most optimal treatment strategy to raise HDL-C and normalize the HDL particle profile in these patients. Hot Topics in Cardiometabolic Disorders Volume 2 • Issue 3 • Year 2011 © FBCommunication Modena (Italy) Cite this article as: Schaefer EJ, Santos RD, Tani M, Schaefer PM, Asztalos BF. Familial high-density lipoprotein deficiency states and premature coronary heart disease. Hot Topics Cardiomet Disord 2011;2(3):7-16. E-mail: ernst.schaefer@tufts.edu Hot Topics in Cardiometabolic Disorders 2011;3:7-16 Copyright © 2011 FBCommunication s.r.l. a socio unico Downloaded from www.hottopicsin.com As shown in Figure 2-upper panel pre-β1 HDL is a very small disk with two molecules of apoA-I forming a belt (in yellow) around approximately 16 molecules of phospholipid (in blue), with a diameter of about 5.6 nm and a molecular weight of about 70 kDa. This particle is converted to small α4 HDL, which is a small disk with 2 molecules of apoA-I, but has about 26 molecules of phospholipid, and about 12 molecules of free cholesterol (in green), with a diameter of about 7.4 nm, and a molecular weight of about 80 kDa. Figure 2-lower panel depicts a model of medium spherical α3 HDL with 2 molecules of apoA-I, 1 molecule of apoA-II, with phospholipid and free cholesterol on its surface, and cholesteryl ester ","PeriodicalId":229022,"journal":{"name":"Hot Topics in Cardiometabolic Disorders","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123697284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combined dyslipidemia with a focus on current and emerging therapeutic approaches 将血脂异常与当前和新兴的治疗方法结合起来
Hot Topics in Cardiometabolic Disorders Pub Date : 1900-01-01 DOI: 10.4147/HTCD-110317
M. Davidson
{"title":"Combined dyslipidemia with a focus on current and emerging therapeutic approaches","authors":"M. Davidson","doi":"10.4147/HTCD-110317","DOIUrl":"https://doi.org/10.4147/HTCD-110317","url":null,"abstract":"","PeriodicalId":229022,"journal":{"name":"Hot Topics in Cardiometabolic Disorders","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127651514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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