Plasmodium Species and Drug Resistance最新文献

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A Double Line of Defense: Heat Shock Proteins and Polyamines Act as Contributing Factors to Drug Resistance of some Plasmodium Parasites 双重防线:热休克蛋白和多胺是一些疟原虫耐药的促进因素

Plasmodium Species and Drug Resistance Pub Date : 2021-11-10 DOI: 10.5772/intechopen.98852

Xolani Henry Makhoba

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引用次数: 2

rRNA Platform Technology for Drug Discovery Methods for Identifying Ligands That Target Plasmodium RNA Structural Motifs 用于鉴定疟原虫RNA结构基序配体的药物发现方法的rRNA平台技术

Plasmodium Species and Drug Resistance Pub Date : 2021-11-10 DOI: 10.5772/intechopen.98776

Harrison Ndung’u Mwangi, Francis Jackim Mulaa

{"title":"rRNA Platform Technology for Drug Discovery Methods for Identifying Ligands That Target Plasmodium RNA Structural Motifs","authors":"Harrison Ndung’u Mwangi, Francis Jackim Mulaa","doi":"10.5772/intechopen.98776","DOIUrl":"https://doi.org/10.5772/intechopen.98776","url":null,"abstract":"Determining the structure of the P. falciparum40s leads to better understanding of the structural basis for its protein-synthesizing roles in the cell. This enables researchers in the field of drug development to run in silico ligand screening experiments using the solved P. falciparum 40S structure as a target against a library of potential anti-malarial compounds. Drug leads identified through this method can lead to further biochemical and In vitro binding studies with the ultimate goal of developing new class of anti-malarial drugs. The use of structure prediction and modeling technologies in this study dramatically reduces the time it takes from target identification to drug lead determination. Furthermore, very many compounds that were previously incapable of being experimentally tested can now be tested in silico against the generated structure. Owing to the increasing utility of bioinformatics and three dimensional structural modeling software, one can accurately build physical models solely from sequence data by unwrapping the information therein on probable motif sites capable of being anchored onto available compounds or aptamers.","PeriodicalId":228370,"journal":{"name":"Plasmodium Species and Drug Resistance","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128829508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0