Rossijskij žurnal gastroènterologii gepatologii koloproktologii最新文献

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Liver Transplantation in the Treatment of Unresectable Hepatocellular Carcinoma in the Absence of Liver Cirrhosis 肝移植治疗无肝硬化不可切除的肝细胞癌

Rossijskij žurnal gastroènterologii gepatologii koloproktologii Pub Date : 2018-08-31 DOI: 10.22416/1382-4376-2018-28-4-76-83

O. Olisov, M. Novruzbekov, I. E. Galankina, L. Zimina, V. Gulyaev, L. V. Donova, M. Khubutiya

引用次数: 2

Small Bowel Bacterial Overgrowth Syndrome in Patients with Bronchial Asthma 支气管哮喘患者的小肠细菌过度生长综合征

Rossijskij žurnal gastroènterologii gepatologii koloproktologii Pub Date : 2018-08-29 DOI: 10.22416/1382-4376-2018-28-4-47-54

N. Potskhverashvili, O. Zolnikova, N. I. Kokina, N. Dzhakhaya, A. V. Sedova, E. Bueverova, A. Trukhmanov

{"title":"Small Bowel Bacterial Overgrowth Syndrome in Patients with Bronchial Asthma","authors":"N. Potskhverashvili, O. Zolnikova, N. I. Kokina, N. Dzhakhaya, A. V. Sedova, E. Bueverova, A. Trukhmanov","doi":"10.22416/1382-4376-2018-28-4-47-54","DOIUrl":"https://doi.org/10.22416/1382-4376-2018-28-4-47-54","url":null,"abstract":"Aim. This work is aimed at studying the role of the small bowel bacterial overgrowth syndrome (SBBOS) in the pathogenesis of bronchial asthma (BA).Materials and methods. The study included 80 BA patients (45 and 35 patients allergic and non-allergic BA forms, respectively). Conventional laboratory and instrumental studies were conducted. SBBOS was confirmed by a hydrogen breath test with lactulose. Patients received conventional basal therapy with combined drugs (long-acting β2-adrenomimetics, and inhaled glucocorticoids). For SBBOS treatment, rifaximin (23 patients) or rifaximin followed by probiotic (B. bifidum, B. longum, B. infantis, L. rhamnosus) for 1 month (22 patients) was administered. Control studies were conducted on the 14th day and following 1 month of treatment.Results. A frequent combination of the small bowel bacterial overgrowth syndrome and bronchial asthma was revealed. 67 % and 43 % of the patients with the allergic form and non-allergic asthma form, respectively, are shown to suffer from SBBOS, p = 0.028. High levels of IgE (p < 0.01) and eosinophils in sputum (p < 0.001), combined with severe impairment of the function of external respiration (p < 0.01) in the case of SBBOS with allergic asthma reflect a more pronounced degree of sensitization of these patients. The correction of composition disorders of the intestinal microflora is accompanied by a statistically significant decrease in the immune response (p < 0.01) and improvement in the function of external respiration (p < 0.001).Conclusion. SBBOS is a significant factor, aggravating the course of bronchial asthma and playing an important role in the development and maintenance of sensitization of patients. ","PeriodicalId":226715,"journal":{"name":"Rossijskij žurnal gastroènterologii gepatologii koloproktologii","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133534171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Hereditary colorectal cancer: genetics and screening diagnostics 遗传性结直肠癌:遗传学和筛查诊断

Rossijskij žurnal gastroènterologii gepatologii koloproktologii Pub Date : 2018-06-05 DOI: 10.22416/1382-4376-2018-28-3-18-25

O. Kit, D. I. Vodolazhsky, Yuriy A. Gevorkyan, N. Soldatkina, F. N. Grechkin, M. A. Kozhushko, Inna Yefimova

{"title":"Hereditary colorectal cancer: genetics and screening diagnostics","authors":"O. Kit, D. I. Vodolazhsky, Yuriy A. Gevorkyan, N. Soldatkina, F. N. Grechkin, M. A. Kozhushko, Inna Yefimova","doi":"10.22416/1382-4376-2018-28-3-18-25","DOIUrl":"https://doi.org/10.22416/1382-4376-2018-28-3-18-25","url":null,"abstract":"Aim of review. To present the data on main forms of hereditary colorectal cancer (CRC) and to discuss issues of its diagnostics, genetic testing and patient management. Summary. CRC is one of the most widespread oncologic diseases and takes the leading positions for morbidity and mortality in the pattern of neoplastic diseases in Russia. In 30% of cases disease development is associated to genetic predisposition, however only 5% of all CRC cases are linked to established hereditary syndromes, such as Lynch syndrome (hereditary non-polyposis colorectal cancer), family adenomatous polyposis, MUTYH-associated polyposis, juvenile polyposis, hereditary mixed polyposis syndrome, Peutz-Jeghers syndrome and serrated polyposis syndrome. The current review presents clinical and genetic features of two basic colorectal hereditary syndromes - Lynch syndrome and family adenomatous polyposis. Conclusion. Both clinical and molecular genetic investigations of hereditary CRC forms make possible individual comprehensive approach for diagnosis verification, evaluation of cancer risk, early diagnostics, treatment and prevention for decrease of morbidity and mortality.","PeriodicalId":226715,"journal":{"name":"Rossijskij žurnal gastroènterologii gepatologii koloproktologii","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125561960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2