Current Perspectives on Viral Disease Outbreaks - Epidemiology, Detection and Control最新文献

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Recombinant Human Interferon-Gamma: Prospects for the Treatment of Chronic Epstein-Barr Viral Infection 重组人γ干扰素:治疗慢性eb病毒感染的前景

Current Perspectives on Viral Disease Outbreaks - Epidemiology, Detection and Control Pub Date : 2022-01-12 DOI: 10.5772/intechopen.101325

Irina A. Rakityanskaya, Tatiana S. Ryabova

{"title":"Recombinant Human Interferon-Gamma: Prospects for the Treatment of Chronic Epstein-Barr Viral Infection","authors":"Irina A. Rakityanskaya, Tatiana S. Ryabova","doi":"10.5772/intechopen.101325","DOIUrl":"https://doi.org/10.5772/intechopen.101325","url":null,"abstract":"Infection of Epstein-Barr virus (EBV) is about 90% among people over the age of 40. The EBV causes a chronic infection that is characterized by chronic or recurrent symptoms and persists for a long time. Recombinant interferon-gamma (IFN-γ) has high clinical and antiviral efficacy in the treatment of herpesvirus infections. 110 patients with chronic EBV infection were examined. The patients were divided into three groups for different treatment regimens: Group 1—IFN-γ therapy (15 injections of Ingaron i/m, 500,000 IU every other day); Group 2—valaciclovir (Valtrex 500 mg × 2 times/day, orally for 2 months); Group 3—valganciclovir (Valcyte 450 mg × 2 times/day, orally for 2 months) and IFN-γ (10–20 injections of Ingaron i/m, 500,000 IU every other day). The best results were obtained in group 3–73.07% negative PCR. In this group, the combination of valganciclovir + IFN-γ was different. We showed that the efficacy of therapy in patients with chronic EBV is determined by the duration of INF-γ administration. We also determined spontaneous and induced production of IFN-α and -γ cytokines in serum and in lymphocyte culture. We demonstrated that in patients with an initially low level of induced IFN-γ, the production of this cytokine significantly increased in three months after the end of therapy.","PeriodicalId":217136,"journal":{"name":"Current Perspectives on Viral Disease Outbreaks - Epidemiology, Detection and Control","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123414066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chikungunya Neurological Manifestations: A Systematic Literature Review 基孔肯雅热神经学表现:系统文献综述

Current Perspectives on Viral Disease Outbreaks - Epidemiology, Detection and Control Pub Date : 2022-01-12 DOI: 10.5772/intechopen.95525

Jucier Gonçalves Júnior, Marília de Oliveira Bringel, Leonardo Rodrigues de Morais, Luiz Fernando de Castro Malinverno, Giselle Vasconcelos Liberato, Myllena Maria de Morais Pereira, Modesto Leite Rolim Neto, Leonardo de Oliveira Cavalcante, Estelita Lima Cândido

{"title":"Chikungunya Neurological Manifestations: A Systematic Literature Review","authors":"Jucier Gonçalves Júnior, Marília de Oliveira Bringel, Leonardo Rodrigues de Morais, Luiz Fernando de Castro Malinverno, Giselle Vasconcelos Liberato, Myllena Maria de Morais Pereira, Modesto Leite Rolim Neto, Leonardo de Oliveira Cavalcante, Estelita Lima Cândido","doi":"10.5772/intechopen.95525","DOIUrl":"https://doi.org/10.5772/intechopen.95525","url":null,"abstract":"Although the most common Chikungunya (do not capitalize the disease unless it is named after a proper noun such as Zika, Ebola or Carrion’s Disease) manifestations are osteoarticular, those which bring the most morbidity and mortality are neurological, where thorough mapping through studies with a methodological outline have not yet been well structured. Therefore, the objective was to review the literature to identify neurological manifestations of CHIKV. We used the Virtual Health Library (VHL) and PubMed with the following descriptors: #1 “Chikungunya” [MeSH]; #2 “neurological manifestations” [MeSH] and their equivalents in the Portuguese language, selecting literature published between July 2007 to January 2018. From the 180 studies that were found, 30 were selected. Findings were divided into two subcategories: “Chikungunya: Typical Neurological Manifestations” and “Chikungunya: Severe Neurological Manifestations”. The studies show that headaches were characterized as the most common symptom in adult patients affected by CHIKV, followed by meningeal involvement. Meningeal involvement is also a more serious clinical scenario associated with encephalitis, convulsions, polyneuropathies such as Guillain-Barré syndrome and death. CHIKV is a public health problem for many reasons including its chronic potential complications. Given the neurological symptoms, this disease is concerning in age extremes, for patients with comorbidities and for patients with more than one viral infection by arboviruses, in whom the most severe neurological manifestations are more common.","PeriodicalId":217136,"journal":{"name":"Current Perspectives on Viral Disease Outbreaks - Epidemiology, Detection and Control","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121475856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trained Immunity-Based Vaccines: A Ready-to-Act Strategy to Tackle Viral Outbreaks 训练有素的免疫疫苗:应对病毒爆发的随时行动战略

Current Perspectives on Viral Disease Outbreaks - Epidemiology, Detection and Control Pub Date : 2021-01-23 DOI: 10.5772/INTECHOPEN.95765

L. Conejero, P. Saz-Leal, J. Subiza

{"title":"Trained Immunity-Based Vaccines: A Ready-to-Act Strategy to Tackle Viral Outbreaks","authors":"L. Conejero, P. Saz-Leal, J. Subiza","doi":"10.5772/INTECHOPEN.95765","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.95765","url":null,"abstract":"Viral outbreaks have become significant threats to global human public health. New emerging viruses, pathogen mutations, and even the progressive loss of efficacy in some existing vaccines are behind this problem, which is amplified by the rapid virus spread given the ease of current mobility. Taking into account that these outbreaks arise in the absence of conventional effective vaccines, alternative approaches based on trained (innate) immunity are being considered. This immunity is dependent on a functional reprogramming of innate immune cells, leading to an enhanced nonspecific response towards different pathogens, including viruses. Trained immunity-based vaccines (TIbVs), defined as vaccine formulations containing trained immunity inducers, could be used during viral outbreaks to confer non-specific protection but also to enhance adaptive specific immune responses. In this chapter, we aim to illustrate how TIbVs could tackle the above-mentioned situations derived from viral outbreaks, reviewing the potential of available TIbVs in such urgent situations with a special mention to COVID-19.","PeriodicalId":217136,"journal":{"name":"Current Perspectives on Viral Disease Outbreaks - Epidemiology, Detection and Control","volume":"86 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114524505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4