Serotonin and the CNS - New Developments in Pharmacology and Therapeutics [Working Title]最新文献

Mathematical Models of Serotonin, Histamine, and Depression 血清素、组胺和抑郁症的数学模型

Serotonin and the CNS - New Developments in Pharmacology and Therapeutics [Working Title] Pub Date : 2021-05-19 DOI: 10.5772/INTECHOPEN.96990

Janet Best, A. M. Buchanan, H. F. Nijhout, P. Hashemi, M. Reed

{"title":"Mathematical Models of Serotonin, Histamine, and Depression","authors":"Janet Best, A. M. Buchanan, H. F. Nijhout, P. Hashemi, M. Reed","doi":"10.5772/INTECHOPEN.96990","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.96990","url":null,"abstract":"The coauthors have been working together for ten years on serotonin, dopamine, and histamine and their connection to neuropsychiatric illnesses. Hashemi has pioneered many new experimental techniques for measuring serotonin and histamine in real time in the extracellular space in the brain. Best, Reed, and Nijhout have been making mathematical models of brain metabolism to help them interpret Hashemi’s data. Hashemi demonstrated that brain histamine inhibits serotonin release, giving a direct mechanism by which inflammation can cause a decrease in brain serotonin and therefore depression. Many new biological phenomena have come out of their joint research including 1) there are two different reuptake mechanisms for serotonin; 2) the effect of the serotonin autoreceptors is not instantaneous and is long-lasting even when the extracellular concentrations have returned to normal; 3) that mathematical models of serotonin metabolism and histamine metabolism can explain Hashemi’s experimental data; 4) that variation in serotonin autoreceptors may be one of the causes of serotonin-linked mood disorders. Here we review our work in recent years for biological audiences, medical audiences, and researchers who work on mathematical modeling of biological problems. We discuss the experimental techniques, the creation and investigation of mathematical models, and the consequences for neuropsychiatric diseases.","PeriodicalId":21701,"journal":{"name":"Serotonin and the CNS - New Developments in Pharmacology and Therapeutics [Working Title]","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88881576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Roles of the Serotoninergic System in Coping with Traumatic Stress 血清素系统在应对创伤应激中的作用

Serotonin and the CNS - New Developments in Pharmacology and Therapeutics [Working Title] Pub Date : 2021-05-12 DOI: 10.5772/INTECHOPEN.97221

T. Vitalis, C. Verney

引用次数: 0

Serotonin, Sleep and Depression: A Hypothesis 血清素、睡眠和抑郁:一个假说

Serotonin and the CNS - New Developments in Pharmacology and Therapeutics [Working Title] Pub Date : 2021-04-19 DOI: 10.5772/INTECHOPEN.96525

V. Kovalzon

{"title":"Serotonin, Sleep and Depression: A Hypothesis","authors":"V. Kovalzon","doi":"10.5772/INTECHOPEN.96525","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.96525","url":null,"abstract":"For most cases of endogenous depression (major depression), the hypothesis of monoamine deficiency, despite a number of limitations it faces, is still considered the most acceptable explanation. The main difficulty faced by this hypothesis is the reason for the decrease in the level of cerebral monoamines (primarily serotonin) during depression. It is assumed either increased activity of the MAO enzyme, which metabolizes serotonin, or a mutation with the loss of function of the gene of the Tph-2 enzyme, which synthesizes serotonin, as possible causes. In this review, a third cause is proposed, which can explain a number of cases of «spontaneous» onset of depressive symptoms in apparently healthy people, as well as links the hypotheses of “monoamine deficiency” and “disturbances in circadian rhythms.” It is assumed that the formation of endogenous depression is due to a combination of two factors: a reduced “basal” level of cerebral serotonin and excessively long pre-morning periods of REM sleep, during which the release of cerebral monoamines stops altogether. As a possible way to of non-drug treatment of depression, not deprivation, but fragmentation of this phase of sleep is suggested, that is much easier for patients to tolerate.","PeriodicalId":21701,"journal":{"name":"Serotonin and the CNS - New Developments in Pharmacology and Therapeutics [Working Title]","volume":"52 4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89053108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Experimental Serotonin Syndrome: Effects of GABA-ergic Medications and 5-HT2-Antagonists 实验性血清素综合征:gaba -能药物和5- ht2拮抗剂的作用

Serotonin and the CNS - New Developments in Pharmacology and Therapeutics [Working Title] Pub Date : 2021-03-16 DOI: 10.5772/INTECHOPEN.96362

R. Nikolov, K. Koleva

引用次数: 0