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Bicyclo[2.2.2]octane (BCO) as a 3D-Rich Bioisostere for the para-Phenyl Group 双环[2.2.2]辛烷(BCO)作为对苯基的富3d生物同分体
Drug Discovery with Privileged Building Blocks Pub Date : 2021-09-07 DOI: 10.1201/9781003190806-6
J. Li, Minmin Yang
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引用次数: 0
Cubanes, Are We There Yet? 古巴人，我们到了吗?
Drug Discovery with Privileged Building Blocks Pub Date : 2021-09-07 DOI: 10.1201/9781003190806-9
J. Li, Minmin Yang
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引用次数: 0
Cyclopropane Derivatives as Metabolically More Robust Bioisosteres for Linear Alkyl Substituents 环丙烷衍生物作为线性烷基取代基代谢更强的生物同位体
Drug Discovery with Privileged Building Blocks Pub Date : 2021-09-07 DOI: 10.1201/9781003190806-13
J. Li, Minmin Yang
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引用次数: 0
Bicyclic Pyridines Containing Ring-Junction N 含环结的双环吡啶
Drug Discovery with Privileged Building Blocks Pub Date : 2021-09-07 DOI: 10.1201/9781003190806-4
J. Li, Minmin Yang
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引用次数: 0
Bicyclo[1.1.1]pentyl (BCP) as an sp3 Carbon-Rich Bioisostere for para-Phenyl and tert-Butyl Groups 双环[1.1.1]戊基(BCP)作为对苯基和叔丁基的sp3富碳生物同分体
Drug Discovery with Privileged Building Blocks Pub Date : 2021-09-07 DOI: 10.1201/9781003190806-5
J. Li, Minmin Yang
{"title":"Bicyclo[1.1.1]pentyl (BCP) as an sp3 Carbon-Rich Bioisostere for para-Phenyl and tert-Butyl Groups","authors":"J. Li, Minmin Yang","doi":"10.1201/9781003190806-5","DOIUrl":"https://doi.org/10.1201/9781003190806-5","url":null,"abstract":"","PeriodicalId":216758,"journal":{"name":"Drug Discovery with Privileged Building Blocks","volume":"86 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132728524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bridge-Fused Rings as m-Phenyl Bioisosteres 作为间苯基生物同分酯的桥合环
Drug Discovery with Privileged Building Blocks Pub Date : 2021-09-07 DOI: 10.1201/9781003190806-8
J. Li, Minmin Yang
{"title":"Bridge-Fused Rings as m-Phenyl Bioisosteres","authors":"J. Li, Minmin Yang","doi":"10.1201/9781003190806-8","DOIUrl":"https://doi.org/10.1201/9781003190806-8","url":null,"abstract":"While saturated p-phenyl isosteres are more and more popular in medicinal chemistry, m-phenyl and o-phenyl fragments do not have many 3-D-rich isosteres. As this review has shown, saturated mphenyl isosteres such as bicyclo[2.2.1]heptane (B, see Fig. 2), bicyclo[2.1.1]hexane (C), bicyclo[3.1.1]heptane (D), and 2oxabicyclo[2.1.1]hexane (E) are gaining popularity. As most 3-D-rich isosteres, they (a) have a higher degree of saturation for a molecule may increase receptor–ligand complementarity, which should mitigate off-target effects; (b) tend to have lower CYP450 inhibitions, thus reducing DDIs tendency; and (c) may have lower melting point and higher solubility; and (d) oxygen-containing isosteres have added advantage of lower lipophilicity.","PeriodicalId":216758,"journal":{"name":"Drug Discovery with Privileged Building Blocks","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133266878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pyridines—The Magic of Phenyl–Pyridyl Switch 吡啶-苯基-吡啶开关的魔力
Drug Discovery with Privileged Building Blocks Pub Date : 2021-09-07 DOI: 10.1201/9781003190806-23
J. Li, Minmin Yang
{"title":"Pyridines—The Magic of Phenyl–Pyridyl Switch","authors":"J. Li, Minmin Yang","doi":"10.1201/9781003190806-23","DOIUrl":"https://doi.org/10.1201/9781003190806-23","url":null,"abstract":"","PeriodicalId":216758,"journal":{"name":"Drug Discovery with Privileged Building Blocks","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128737580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bicyclo[3.1.0]hexanes
Drug Discovery with Privileged Building Blocks Pub Date : 2021-09-07 DOI: 10.1201/9781003190806-7
J. Li, Minmin Yang
{"title":"Bicyclo[3.1.0]hexanes","authors":"J. Li, Minmin Yang","doi":"10.1201/9781003190806-7","DOIUrl":"https://doi.org/10.1201/9781003190806-7","url":null,"abstract":"","PeriodicalId":216758,"journal":{"name":"Drug Discovery with Privileged Building Blocks","volume":"156 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114514216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pyrazines 吡嗪
Drug Discovery with Privileged Building Blocks Pub Date : 2021-09-07 DOI: 10.1201/9781003190806-20
J. Li, Minmin Yang
{"title":"Pyrazines","authors":"J. Li, Minmin Yang","doi":"10.1201/9781003190806-20","DOIUrl":"https://doi.org/10.1201/9781003190806-20","url":null,"abstract":"","PeriodicalId":216758,"journal":{"name":"Drug Discovery with Privileged Building Blocks","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115847371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Piperidine, the Enchanted Ring 派珀里丁，魔法戒指
Drug Discovery with Privileged Building Blocks Pub Date : 2021-09-07 DOI: 10.1201/9781003190806-19
J. Li, Minmin Yang
{"title":"Piperidine, the Enchanted Ring","authors":"J. Li, Minmin Yang","doi":"10.1201/9781003190806-19","DOIUrl":"https://doi.org/10.1201/9781003190806-19","url":null,"abstract":"","PeriodicalId":216758,"journal":{"name":"Drug Discovery with Privileged Building Blocks","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125314885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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