Rhinology journal最新文献

Neurofilament light chain is associated with olfactory dysfunction in US adults: findings from National Health and Nutrition Examination Survey 神经丝蛋白轻链与美国成年人的嗅觉功能障碍有关：全国健康与营养调查的结果

Rhinology journal Pub Date : 2024-07-01 DOI: 10.4193/rhin24.001

Juanying Zhen, Jiayu Huang, Qing Cao, Bernard Man, Yung Cheung, Chao Li

{"title":"Neurofilament light chain is associated with olfactory dysfunction in US adults: findings from National Health and Nutrition Examination Survey","authors":"Juanying Zhen, Jiayu Huang, Qing Cao, Bernard Man, Yung Cheung, Chao Li","doi":"10.4193/rhin24.001","DOIUrl":"https://doi.org/10.4193/rhin24.001","url":null,"abstract":"Background: Many individuals who have olfactory dysfunction are not aware of their impairment, which results in delayed detection of potentially hazardous situations. Simple and accurate methods for objectively assessing olfactory function are needed. In this study, we aim to investigate the utility of serum neurofilament light chain (NfL) levels as an indicator of olfactory dysfunction. Methodology: We analysed data on 1290 participants aged 40 years and older, who had valid data on olfaction and NfL level from the National Health and Nutrition Examination Survey 2013–2014. Multivariable modeling was used to investigate the relationship between olfactory dysfunction and NfL. Results: Among 1290 participants, 174 participants had olfactory dysfunction based on the results of the NHANES Pocket Smell Test. In ordinal regression models, objective olfactory dysfunction was associated with NfL. After adjusting for age, sex, race/ethnicity, diabetes, smoking, olfaction-related medical history, Parkinson's disease and Alzheimer’s disease, the association remained significant. In logistic regression models, compared to participants with lower levels of NfL in the first tertile, those in the second and third tertiles had higher odds of objective olfactory dysfunction. There was no association between self-reported olfactory dysfunction and NfL tertiles. Conclusions: A strong association between objective olfactory dysfunction and serum NfL level was observed. NfL, independent of age, is a reliable marker indicating the development of olfactory dysfunction. The measurement of serum NfL level provides valuable support for assessment of olfactory dysfunction in clinical practice.","PeriodicalId":21310,"journal":{"name":"Rhinology journal","volume":"100 s8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141695680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-life effectiveness of dupilumab in chronic rhinosinusitis with nasal polyps. Results from eight Hungarian centres with 12-month follow-up 杜必鲁单抗对伴有鼻息肉的慢性鼻炎的实际疗效。匈牙利八家中心为期 12 个月的随访结果

Rhinology journal Pub Date : 2024-06-01 DOI: 10.4193/rhin23.278

A. Kiricsi, Z. Bella, H. Kraxner, T. Szaloki, Z. Fent, B. Liktor, J. Huszka, P. Laszlo, D. Gobol, F. Helfferich, Z. Vaska, Z. Piski, L. Juhasz-Loisch, B. Horvath, D. Galantai, N. Krisztin, L. Toth, A. Bodi, M. Matuz, L. Lujber, A. Hirschberg

{"title":"Real-life effectiveness of dupilumab in chronic rhinosinusitis with nasal polyps. Results from eight Hungarian centres with 12-month follow-up","authors":"A. Kiricsi, Z. Bella, H. Kraxner, T. Szaloki, Z. Fent, B. Liktor, J. Huszka, P. Laszlo, D. Gobol, F. Helfferich, Z. Vaska, Z. Piski, L. Juhasz-Loisch, B. Horvath, D. Galantai, N. Krisztin, L. Toth, A. Bodi, M. Matuz, L. Lujber, A. Hirschberg","doi":"10.4193/rhin23.278","DOIUrl":"https://doi.org/10.4193/rhin23.278","url":null,"abstract":"Background: Research on the immune mechanism behind chronic rhinosinusitis (CRS) has revealed various new endotypes, leading to targeted therapies, especially for severe uncontrolled CRS. Biologics are novel therapeutic strategies providing targeted treatment for the difficult-to-treat recalcitrant CRSwNP patients. Dupilumab is a fully human-derived monoclonal antibody that binds to IL4Rα, inhibiting the signalling of both IL-4 and IL-13. In Hungary, it is approved for the treatment of uncontrolled CRSwNP according to criteria based on the EPOS2020 and the Hungarian guidelines. Methodology: This study aimed to collect and evaluate real-world therapeutic data of CRSwNP patients treated with dupilumab. One hundred thirty-five patients from eight different referral centres have been enrolled in this study, who received dupilumab since 2020. All subjects were adult patients (>18 years) with uncontrolled CRSwNP. Baseline data collection included demographics, medical history, previous surgeries, related comorbidities, total endoscopic nasal polyp score (NPS), SNOT22, nasal congestion parameters measured with visual analogue scale (VAS) and nasal obstruction evaluation scale (NOSE), loss of smell score (LSS) and eosinophil count. 300 mg dupilumab was administered subcutaneously every second week. Follow up visits were performed after 6 and 12 months. Results: After 6 and 12 months of treatment significant improvement was detected in all clinical parameters. Safety was proved, no severe side effects occurred, and no rescue treatment was necessary. Conclusions: Our real-life findings show that continuous dupilumab treatment is effective and safe in daily clinical practice in CRSwNP and other type 2 comorbidities such as bronchial asthma and NERD.","PeriodicalId":21310,"journal":{"name":"Rhinology journal","volume":"52 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141279528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abstract book 27th CONGRESS OF THE EUROPEAN RHINOLOGIC SOCIETY in conjunction with 37nd INTERNATIONAL SYMPOSIUM OF INFECTION & ALLERGY OF THE NOSE and 19th CONGRESS OF THE INTERNATIONAL RHINOLOGIC SOCIETY London, United Kingdom April 22-26, 2018 Abstracts 摘要:第27届欧洲鼻学会大会暨第37届国际鼻感染与过敏研讨会暨第19届国际鼻学会大会于2018年4月22日至26日在英国伦敦举行

Rhinology journal Pub Date : 2018-06-01 DOI: 10.4193/rhin18.901

引用次数: 0

Symptoms of chronic rhinosinusitis differentially impact general health-related quality of life 慢性鼻窦炎的症状对总体健康相关生活质量的影响存在差异

Rhinology journal Pub Date : 2016-12-01 DOI: 10.4193/rhino16.211

L. Hoehle, K. Phillips, R. Bergmark, D. Caradonna, S. Gray, A. Sedaghat

{"title":"Symptoms of chronic rhinosinusitis differentially impact general health-related quality of life","authors":"L. Hoehle, K. Phillips, R. Bergmark, D. Caradonna, S. Gray, A. Sedaghat","doi":"10.4193/rhino16.211","DOIUrl":"https://doi.org/10.4193/rhino16.211","url":null,"abstract":"Background: The degree to which different sinonasal symptoms contribute to the overall quality of life (QOL) detriment in chronic rhinosinusitis (CRS) patients remains unknown. In this study we sought to characterize the effect of different CRS symptoms on the general health-related QOL in patients. Methodology: We performed a prospective cross-sectional study of 131 adult patients with CRS. Sinonasal symptoms were evaluated using the 22-item Sinonasal Outcomes Test (SNOT-22) and general health-related QOL was evaluated using the EuroQol 5-Dimensional general health-related QOL survey (EQ5D) and visual analog scale (EQ5D-VAS). Health utility values (HUV) were determined using responses to the EQ5D. SNOT-22 scores were broken down into subdomain scores for sleep, nasal, otologic/facial pain and emotional function symptoms. Results: The otologic/facial pain subdomain score consistently had the largest impact on EQ5D-VAS and HUV. After otologic/facial pain, the sleep subdomain score had the second largest effect while the nasal subdomain score had the least impact on general health-related QOL. Conclusions: Different types of CRS symptoms - most prominently otologic/facial pain and sleep-related symptoms - and their underlying pathophysiologic mechanisms may differentially affect the general health-related QOL detriment associated with CRS. These findings raise the possibility that treatment of the various symptoms associated with CRS may lead to differential improvement in general-health related QOL.","PeriodicalId":21310,"journal":{"name":"Rhinology journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85172832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

The role of endothelin-1 and endothelin receptor antagonists in allergic rhinitis inflammation: ovalbumin-induced rat model 内皮素-1和内皮素受体拮抗剂在变应性鼻炎中的作用:卵清蛋白诱导的大鼠模型

Rhinology journal Pub Date : 2016-09-01 DOI: 10.4193/rhino15.059

A. Tatar, M. Yayla, D. Kose, Z. Halıcı, O. Yoruk, E. Polat

{"title":"The role of endothelin-1 and endothelin receptor antagonists in allergic rhinitis inflammation: ovalbumin-induced rat model","authors":"A. Tatar, M. Yayla, D. Kose, Z. Halıcı, O. Yoruk, E. Polat","doi":"10.4193/rhino15.059","DOIUrl":"https://doi.org/10.4193/rhino15.059","url":null,"abstract":"Objective: Desloratadine is a biologically active metabolite of loratadine which is indicated for the treatment of allergic rhinitis. Bosentan is a dual endothelin receptor antagonist used to treatment of pulmonary artery hypertension (PAH). In this study, we aimed to determine the role of endothelins in allergic rhinitis (AR) and the effects of endothelin receptor antagonists in AR rat models through comparison with desloratadine. Methods: In total, 20 adult Sprague-Dawley rats were used in this study. An ovalbumin-induced allergic rhinitis model was formed in three study groups except for the control group. Bosentan (100 mg/kg/day) was given to the bosentan-treated group for 7 days and desloratadine (10 mg/kg/day) was administered to the antihistaminic-treated group for 7 days. Nasal symptom scorings and histopathological examinations of the nasal tissues were carried out. Serum IgE levels and ET-1 and TNF-alpha mRNA expression levels were analysed. Between group comparisons for nasal symptoms, histopathological analysis, and molecular analyses were performed with a one-way ANOVA and Duncans multiple comparison tests. Significance was accepted at p smaller than 0.05. Results: Bosentan inhibited nasal symptom more significantly than desloratadine. The IgE level, ET-1 and TNF-alpha mRNA expression levels statistically increased in the allergic rhinitis group when compared to other groups. Conversely, the bosentan-treatment group showed a significant recovery from the same parameters. The deterioration in histopathological parameters reached the highest levels in the allergic rhinitis group. The histopathological findings were close to those of the control group in the bosentan and antihistaminic-treated group. Conclusions: ET-1 is one of the mediators that impact AR development and ET-1 antagonists can be useful for symptom control and for decreasing allergic inflammation in AR patients.","PeriodicalId":21310,"journal":{"name":"Rhinology journal","volume":"124 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88076759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Altered expression and signalling of EP2 receptor in nasal polyps of AERD patients: role in inflammation and remodelling EP2受体在AERD患者鼻息肉中的表达和信号传导改变:在炎症和重塑中的作用

Rhinology journal Pub Date : 2016-09-01 DOI: 10.4193/rhino15.207

L. Machado-Carvalho, R. Torres, M. Pérez-González, I. Alobid, J. Mullol, L. Pujols, J. Roca‐Ferrer, C. Picado

{"title":"Altered expression and signalling of EP2 receptor in nasal polyps of AERD patients: role in inflammation and remodelling","authors":"L. Machado-Carvalho, R. Torres, M. Pérez-González, I. Alobid, J. Mullol, L. Pujols, J. Roca‐Ferrer, C. Picado","doi":"10.4193/rhino15.207","DOIUrl":"https://doi.org/10.4193/rhino15.207","url":null,"abstract":"Background: Down-regulation of the E-prostanoid (EP)2 receptor has been reported in aspirin exacerbated respiratory disease (AERD). We aimed to evaluate the expression and activation of EP receptors in AERD and their role in prostaglandin (PG) E2 signalling. Methods: Samples were obtained from nasal mucosa of control subjects (NM-C, n=7) and from nasal polyps of AERD patients (NP-AERD, n=7). Expression of EP1-4 was assessed at baseline. Fibroblasts were stimulated with receptor agonists to measure cAMP levels, cell proliferation and granulocyte-macrophage colony-stimulating factor (GM-CSF) release. Results: NM-C and NP-AERD samples and fibroblasts expressed EP2, EP3 and EP4 at baseline. Lower expression of EP2 and higher expression of EP4 was observed in NP-AERD compared with NM-C. Stimulation with PGE2 and butaprost caused a higher increase in cAMP in NM-C than in NP-AERD. On the contrary, CAY10598 produced a higher production of cAMP in NP-AERD compared with NM-C. The anti-proliferative effect of PGE2 and butaprost was lower in NP-AERD than in NM-C fibroblasts. Similarly, the capacity of PGE2 and butaprost to inhibit GM-CSF release was lower in NP-AERD than in NM-C. Conclusions: The altered expression of EP2 in AERD may contribute to reduce the capacity of PGE2 to mediate anti-proliferative and anti-inflammatory effects.","PeriodicalId":21310,"journal":{"name":"Rhinology journal","volume":"123 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81676786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Automated assessment of intranasal trigeminal function 鼻内三叉神经功能的自动评估

Rhinology journal Pub Date : 2016-03-01 DOI: 10.4193/rhino15.002

T. Hummel, C. Kaehling, F. Grosse

{"title":"Automated assessment of intranasal trigeminal function","authors":"T. Hummel, C. Kaehling, F. Grosse","doi":"10.4193/rhino15.002","DOIUrl":"https://doi.org/10.4193/rhino15.002","url":null,"abstract":"Background: The intranasal trigeminal system is a key player in the perception of intranasal airflow. Why it has not been studied very well may be due to the lack of techniques that allow for fast, reliable and inexpensive routine investigation of the system. The basis of the current study is the notion that--within limits--the intranasal trigeminal system detects the overall mass of a stimulus and not just its concentration. Thus, changing the duration of the stimulus at a given concentration has a similar effect as changing its concentration. Methodology: Ninety-nine normosmic subjects participated [48 women and 51 men; mean (range) age = 45 years (20-88 years)]. In addition, 50 patients with olfactory loss were investigated once (28 women, 22 men; mean age 58 years, SD = 14 years; age range 24-88 years; causes of olfactory loss: viral infections n = 22, head trauma n = 8, chronic sinunasal disease n = 3, idiopathic n = 17). CO2-stimuli with various durations (multiples of 50 ms) were presented through a standard bilateral nasal cannula at an interval of 10 s; stimulus duration was increased by 50 ms from one stimulus presentation to the next, until the subject pushed a button indicating a painful sensation. This was the basis for automated assessment of CO2-pain responsiveness. Results: This current study had four main findings: (1) Using the new, automated device CO2 pain responsiveness can be measured reliably, (2) CO2 pain responsiveness correlates with olfactory function, (3) as with olfaction, women are more sensitive to CO2 , and CO2-pain responsiveness also correlates with aging, (4) CO2-pain responsiveness is lower in patients with olfactory loss compared to normosmic, healthy controls, even when controlling for age. Conclusion: We have demonstrated that the current approach is a reliable and valid measure of intranasal trigeminal function.","PeriodicalId":21310,"journal":{"name":"Rhinology journal","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78456589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Follow-up of Thalidomide treatment in patients with Hereditary Haemorrhagic Telangiectasia 沙利度胺治疗遗传性出血性毛细血管扩张症的随访

Rhinology journal Pub Date : 2015-12-01 DOI: 10.4193/rhino14.289

A. Hosman, C. Westermann, R. Snijder, F. Disch, C. Mummery, J. Mager

{"title":"Follow-up of Thalidomide treatment in patients with Hereditary Haemorrhagic Telangiectasia","authors":"A. Hosman, C. Westermann, R. Snijder, F. Disch, C. Mummery, J. Mager","doi":"10.4193/rhino14.289","DOIUrl":"https://doi.org/10.4193/rhino14.289","url":null,"abstract":"Background: Patients with a hereditary vascular disorder called Rendu-Osler-Weber syndrome (Hereditary Haemorrhagic Telangiectasia, HHT) haemorrhage easily due to weak-walled vessels. Haemorrhage in lungs or brain can be fatal but patients suffer most from chronic and prolonged nosebleeds (epistaxis), the frequency and intensity of which increases with age. Several years ago, it was discovered serendipitously that the drug Thalidomide had beneficial effects on the disease symptoms in several of a small group of HHT patients: epistaxis and the incidence of anaemia were reduced and patients required fewer blood transfusions. In addition, they reported a better quality of life. However, Thalidomide has significant negative side effects, including neuropathy and fatigue. Methods: We followed up all HHT patients in the Netherlands who had been taking Thalidomide at the time the original study was completed to find out (i) how many had continued taking Thalidomide and for how long (ii) the nature and severity of any side-effects and (iii) whether side-effects had influenced their decision to continue taking Thalidomide. Results: Only a minority of patients had continued taking the drug despite its beneficial effects on their symptoms and that the side effects were the primary reason to stop. Conclusion: Despite symptom reduction, alternative treatments are still necessary for epistaxis in HHT patients and a large-scale clinical trial is not justified although incidental use in the most severely affected patients can be considered.","PeriodicalId":21310,"journal":{"name":"Rhinology journal","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77295224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2