International Journal of Clinical and Molecular Oncology最新文献

{"title":"Prognostic Significance of Degree of Anaemia and Blood Transfusions in Gastric Cancer Patients","authors":"S. Gilani","doi":"10.59657/2993-0197.brs.23.003","DOIUrl":"https://doi.org/10.59657/2993-0197.brs.23.003","url":null,"abstract":"Background: Anaemia is a common complication of many solid tumours and occurs in approximately 41 % of patients with advanced gastric cancer at the time of diagnosis. Studies have shown that anaemia is an independent prognostic factor in gastric cancer, however it is less clear if blood transfusion alters the outcome in these patients. Aim of this study is to evaluate the effect of anaemia and blood transfusion on survival in advanced gastric cancer patients at our institution. Methods: This is a retrospective review of electronic medical records of gastric cancer patients treated from January to December 2013. Patients' demographics and clinical data was collected and analysed in relation to various factors including level of haemoglobin and use of blood transfusion. Survival was calculated using Univariate, multivariate and Kaplan-Meier survival analysis. Results: A total of 112 patients were identified including 79 (70%) males and 33 (30%) females with a median age of 73 years. Vast majority (n=88, 79%) of patients had locally advanced (T4 or node positive) disease at initial presentation. Eighty-three patients did not proceed to surgery after neoadjuvant chemotherapy due to inoperable disease. Initial Haemoglobin was >100 gram per litre in 28 (25%) patients. Nineteen patients had Haemoglobin of <80 gram per litre. 96 (86%) patients received blood transfusion. Overall, 98 (87.5%) patients died. The estimated median overall survival was 12 months (95% CI=11-81; SD=17). The 1-, 3-, and 5-years OS were 55%, 30% and 10% respectively. The median progression free survival (PFS) with any treatment was 10 months (SD=20). Univariate analysis showed statistical significance of level of Hb and surgical resection to overall survival (P=0.0122 and P=0.0001). Multivariate analysis showed disease stage, surgical resection and Hb level as independent factors to the outcome. Conclusion: The point prevalence of anaemia in our gastric cancer patients during treatment had an effect on overall survival. The outcome couldn't be improved with blood transfusion. Our findings indicate the need for a consistent diagnostic and treatment approach to anaemia in this setting.","PeriodicalId":210002,"journal":{"name":"International Journal of Clinical and Molecular Oncology","volume":"118 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116350794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comparative Study of The Clinical Outcomes Using Conventional Manual Staplers and Circular Powered Staplers in Patients Undergoing Left Sided Colorectal Anastomosis","authors":"H. Singhavi","doi":"10.59657/2993-0197.brs.23.002","DOIUrl":"https://doi.org/10.59657/2993-0197.brs.23.002","url":null,"abstract":"Aim: The aim of our study was to assess safety and efficacy of powered circular staplers for colorectal anastomosis and its comparison with conventional (manual staplers). Method: It’s a single institute, single surgeon based retrospective study to compare powered staplers with manual for the patient’s undergoing anastomosis in colorectal surgery. We assessed the two techniques on the basis of type of surgery, technical problems, intraoperative leak, post-operative leak, blood transfusion, post-operative complication rates, adverse events, additional use of analgesics, antibiotics and readmission rates. SPSS version 20 was used to perform the statistical analysis. Result: Study consisted of forty- eight patients who underwent surgery for colorectal disease. Mean operating time was same for both the groups (3.33 hours). One post-operative leak was observed in manual stapler anastomosis. Four patients had complications including anastomotic leak, anastomotic stricture, wound infection and perianal pain in our study, amongst them three patients underwent manual anastomosis while one patient underwent powered anastomosis. One patient in each arm required readmission. Three patients who underwent powered stapler anastomosis required higher analgesics and higher antibiotics as compared to none in manual, however it was not statistically significant. The mean pain score for patient in powered stapler and manual stapler was 2.96 and 2.92 respectively(p<0.851), while mean length of stay was 7.04 for powered and 6.1 for manual stapler(p<0.08). Conclusion: In our preliminary study, powered stapler was safe and efficacious without any added complications and adverse events. We observed comparable intraoperative and higher trends of post-operative complication rates in manual stapler group.","PeriodicalId":210002,"journal":{"name":"International Journal of Clinical and Molecular Oncology","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122189984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes With Optimal Treatment in Geriatric Head and Neck Cancers – Tertiary Cancer Centre Experience","authors":"I. Ahmed","doi":"10.59657/2993-0197.brs.22.001","DOIUrl":"https://doi.org/10.59657/2993-0197.brs.22.001","url":null,"abstract":"Aim: Older patients with locally advanced head and neck cancers (LA-HNC) are under-represented in clinical trials and denied standard treatment with concurrent Chemo-radiation. Most are treated with Radiotherapy (RT) alone. However, with the use of Intensity Modulated Radiation Therapy (IMRT) and good supportive care, even this cohort of patients can be considered for chemo-radiation. Methods and Materials: 69 patients with age >65 years with LA-HNC treated between April 2015 and December 2019 in our Institute were prospectively evaluated for treatment compliance and outcomes. All patients were planned to receive 70Gy in 33-35 fractions with IMRT and weekly Cisplatin at a dose of 40mg/m2 (or Carboplatin-AUC-2). Loco-regional Control (LRC), Overall survival (OS) and prognostic factors were evaluated. Results: Median age at presentation was 67 years (65-81). 54 were male. 64% had Karnofsky Performance Status of >90. 42% had Oropharyngeal Primary. 17% had co-morbidities. 66% had T3 disease, 77% had Node positive disease. 54% had stage III disease. All patients completed 70Gy. 81% patients received at least 5 (>200mg/m2) chemotherapy cycles. Acute Grade3 toxicity was seen in 20% of patients. 64% had complete response. With a median follow up of 23.6 months (3-71), OS was 53.5%. Estimated 2-year LRC was 60%; estimated 2- and 5-year OS was 53.5% and 34.3% respectively. On Univariate analysis, age <70 years, Cisplatin use, limited nodal disease, Stage III and complete response to treatment showed good OS (p<0.05). Conclusion: Definitive chemo-IMRT approach in older LA-HNC is well tolerated with good clinical outcomes. Hence older age should not be a barrier for standard treatment.","PeriodicalId":210002,"journal":{"name":"International Journal of Clinical and Molecular Oncology","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128415897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}