Journal of Vitamins and Minerals最新文献

筛选
英文 中文
The Pharmacokinetics of Orally Administered Calcium Pantothenate in Healthy Adults 健康成人口服泛酸钙的药代动力学
Journal of Vitamins and Minerals Pub Date : 1900-01-01 DOI: 10.29011/jvm-106.100006
Satish Rao, A. Wade, U. Sinha, A. Shaywitz, Shafique N. Virani, D. Gretler, T. Reilly, Bruce H. Morimoto, R. Escandon
{"title":"The Pharmacokinetics of Orally Administered Calcium Pantothenate in Healthy Adults","authors":"Satish Rao, A. Wade, U. Sinha, A. Shaywitz, Shafique N. Virani, D. Gretler, T. Reilly, Bruce H. Morimoto, R. Escandon","doi":"10.29011/jvm-106.100006","DOIUrl":"https://doi.org/10.29011/jvm-106.100006","url":null,"abstract":"Pantothenic acid, aka Vitamin B5, is essential for production of coenzyme-A, an important component of energy metabolism. The pharmacokinetics (PK) of orally administered calcium pantothenate are not well characterized. This single-center, open-label study of 40 adults investigated single and multidose PK of orally administered calcium pantothenate. Tolerability of high doses and impact of food were also evaluated. This study included Single Ascending Dose (SAD) and Multiple Dose (MD) periods. For the SAD, four sequential cohorts of 8 subjects received single doses of calcium pantothenate after an overnight fast. Doses were 500 mg, 1000 mg, 2000 mg and 5000 mg; with the 5000 mg dose repeated following a 2-week washout and after a highfat meal. In the MD period, 8 subjects received 2000 mg daily for 14 days. PK samples were collected for 192 hours post-last dose in the SAD and MD periods, with frequent sampling on Days 1 and 14, and pre-dose samples on Days 12 and 13 in the MD group. Absorption was rapid with peak concentrations reached approximately 1-hour post-dose under fasted conditions. Exposure (AUC) increased with dose from 500 to 2000 mg with no further increase between 2000 and 5000 mg. Terminal half-life averaged 225 hours. Peak exposure (Cmax) increased greater than dose-proportionally from 500 to 2000 mg. Food delayed absorption by 2 hours (1.002 versus 2.995 hours), and increased AUC by 55%. Steady state was achieved by Day 14 with a 3.1-fold accumulation for AUC0-24. No deaths, serious adverse events, or discontinuations for adverse events occurred.","PeriodicalId":209633,"journal":{"name":"Journal of Vitamins and Minerals","volume":"308 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132132999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信