Polycystic Ovarian Syndrome最新文献

Effect of Aromatase Inhibitors versus Clomiphene Citrate for Ovulation Induction in Infertile Women with Ovulatory Dysfunction (PCO) 芳香化酶抑制剂与枸橼酸克罗米芬对排卵功能障碍不孕妇女的诱导作用

Polycystic Ovarian Syndrome Pub Date : 2020-02-13 DOI: 10.5772/intechopen.90270

H. Abduljabbar, Magda M. Hagras, Rania Magadmy

{"title":"Effect of Aromatase Inhibitors versus Clomiphene Citrate for Ovulation Induction in Infertile Women with Ovulatory Dysfunction (PCO)","authors":"H. Abduljabbar, Magda M. Hagras, Rania Magadmy","doi":"10.5772/intechopen.90270","DOIUrl":"https://doi.org/10.5772/intechopen.90270","url":null,"abstract":"A RCT conducted to assess the efficacy of letrozole as an ovulation induction agent in infertile women, and to compare the effectiveness of letrozole with the current standard agent, clomiphene citrate given for three successive cycles on the induction of ovulation. Forty-five infertile women with anovulation included, the subjects were randomly divided into two groups; subjects were allocated to either CC (100) or letrozole (5 mg) daily—5 days starting on the third day of menses, for 3 months. On stimulation day 12 subjects, serum estradiol and transvaginal sonography to document the number of follicles was done. On stimulation day 21 subjects, serum progesterone and ultrasound for the thickness of endometrium was done. Participants were followed-up monthly. Results revealed that the mean number of follicles reaching >18 mm and endometrial thickness in the letrozole comparable to those receiving clomiphene citrate. Letrozole showed lower estradiol level compared to Clomiphene citrate ( P < 0.05). Ovulation occurred in 84.4%, 78.1% in the letrozole and clomiphene citrate, respectively, and pregnancy rate is 18.8% in the letrozole group compared to 15% in the clomiphene citrate group. In conclusion, there was no significant increase in the number of follicles, endometrial thickness and pregnancy rate induced by letrozole compared with clomiphene citrate.","PeriodicalId":20325,"journal":{"name":"Polycystic Ovarian Syndrome","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90076177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Clinical Impact of Insulin Resistance in Women with Polycystic Ovary Syndrome 多囊卵巢综合征患者胰岛素抵抗的临床影响

Polycystic Ovarian Syndrome Pub Date : 2020-01-10 DOI: 10.5772/intechopen.90749

M. Orbetzova

引用次数: 5

Clinical Features of PCOS 多囊卵巢综合征的临床特点

Polycystic Ovarian Syndrome Pub Date : 2019-11-25 DOI: 10.5772/INTECHOPEN.89961

Bassim Alsadi

{"title":"Clinical Features of PCOS","authors":"Bassim Alsadi","doi":"10.5772/INTECHOPEN.89961","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.89961","url":null,"abstract":"Abstract Polycystic ovary syndrome (PCOS) is a widespread pathology that affects multiple aspects of the general health of women, with long-term effects that go well beyond the reproductive age. The considerable variability of the clinical presentation, together with the lack of universally accepted diagnostic criteria, has so far contributed to making it difficult to identify a clear etiology of the disease. The exact etiology of PCOS is still not perfectly clear to date. It is therefore a multifactorial etiology, sharing of genetic and environmental factors. The contribution of genetics to the pathogenesis of PCOS is not due to a single gene but inheritance of gene clusters. The term “polycystic ovary syndrome” does not completely reflect the complexity of this syndrome which manifests a wide spectrum of clinical manifestations and comorbidity and important metabolic implications. PCOS patients showed an increase risk of developing type 2 diabetes mellitus, dyslipidaemia, endometrial cancer and cardiovascular diseases. The clinical aspects of PCOS are hyperandrogenism, oligomenorrhoea and ultrasound morphology of the ovary. The identification of the different manifestations of PCOS in the various phases of life, can, of course, help to organize individual therapeutic strategies and likely to prevent long-term metabolic consequences. The therapeutic choices will be based on the type and extent of the disorders and if there is a desire for pregnancy.","PeriodicalId":20325,"journal":{"name":"Polycystic Ovarian Syndrome","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77556016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Computational Systems Analysis on Polycystic Ovarian Syndrome (PCOS) 多囊卵巢综合征(PCOS)的计算系统分析

Polycystic Ovarian Syndrome Pub Date : 2019-10-30 DOI: 10.5772/INTECHOPEN.89490

N. Afiqah‐Aleng, Z. Mohamed-Hussein

{"title":"Computational Systems Analysis on Polycystic Ovarian Syndrome (PCOS)","authors":"N. Afiqah‐Aleng, Z. Mohamed-Hussein","doi":"10.5772/INTECHOPEN.89490","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.89490","url":null,"abstract":"Complex diseases are caused by a combination of genetic and environmental factors. Unraveling the molecular pathways from the genetic factors that affect a phenotype is always difficult, but in the case of complex diseases, this is further complicated since genetic factors in affected individuals might be different. Polycystic ovarian syndrome (PCOS) is an example of a complex disease with limited molecular information. Recently, PCOS molecular omics data have increasingly appeared in many publications. We conduct extensive bioinformatics analyses on the data and perform strong integration of experimental and computational biology to understand its complex biological systems in examin-ing multiple interacting genes and their products. PCOS involves networks of genes, and to understand them, those networks must be mapped. This approach has emerged as powerful tools for studying complex diseases and been coined as network biology. Network biology encompasses wide range of network types including those based on physical interactions between and among cellular components and those baised on similarity among patients or diseases. Each of these offers distinct biological clues that may help scientists transform their cellular parts list into insights about complex diseases. This chapter will dis-cuss some computational analysis aspects on the omics studies that have been conducted in PCOS.","PeriodicalId":20325,"journal":{"name":"Polycystic Ovarian Syndrome","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77979660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Endocrine Characteristics and Regulatory Mechanism of Follicular Development and Ovulation Failure in Mammalian Ovary 哺乳动物卵巢卵泡发育和排卵失败的内分泌特征及调控机制

Polycystic Ovarian Syndrome Pub Date : 2019-10-09 DOI: 10.5772/intechopen.89625

Zhenghong Zhang, Yan Zhang, Fengping Lin, Zhengchao Wang

{"title":"Endocrine Characteristics and Regulatory Mechanism of Follicular Development and Ovulation Failure in Mammalian Ovary","authors":"Zhenghong Zhang, Yan Zhang, Fengping Lin, Zhengchao Wang","doi":"10.5772/intechopen.89625","DOIUrl":"https://doi.org/10.5772/intechopen.89625","url":null,"abstract":"In mammals, the follicular development and following ovulation are regulated by reproductive hormones, while polycystic ovary syndrome (PCOS) is an endocrine disorder syndrome with reproductive dysfunction and abnormal glucose metabolism in most PCOS women. Its characteristics are hyperandrogenism, ovarian dysfunction, and the exclusion of other androgen excess or related dis-eases. Its clinical characteristics are large antral follicle pool from which to recruit and persistent anovulation. The incidence of PCOS in women of childbearing age ranged from 4 to 12%. About one-third of infertility cases had no ovulation, and 90% of them had PCOS. Therefore, further studying the regulatory mechanism of follicular hyperrecruitment and anovulation can provide theoretical basis for exploring the pathogenesis of PCOS and guiding clinical treatment, especially for protecting female fertility and preventing the occurrence of metabolic disorder syndrome. The present article will review the progress in endocrine characteristics and regulatory mechanism of follicular development and ovulation failure in the mammalian ovary.","PeriodicalId":20325,"journal":{"name":"Polycystic Ovarian Syndrome","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75872011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Expression and Contribution of Insulin Signaling Pathway to the Development of Polycystic Ovary Syndrome 胰岛素信号通路在多囊卵巢综合征发生中的表达及作用

Polycystic Ovarian Syndrome Pub Date : 2019-09-25 DOI: 10.5772/intechopen.89246

Qingqiang Lin, Hong Zhang, Jiu-Ru Zhao, Zhengchao Wang

引用次数: 4

Effects of Exercise Intervention on the Improvement of Polycystic Ovary Syndrome 运动干预对多囊卵巢综合征改善的影响

Polycystic Ovarian Syndrome Pub Date : 2019-09-19 DOI: 10.5772/intechopen.88896

Shaobing Wang, Zhenghong Zhang, Yiping Liu

引用次数: 2

Interplay between Oxidative Stress and Chronic Inflammation in PCOS: The Role of Genetic Variability in PCOS Risk and Treatment Responses PCOS中氧化应激和慢性炎症的相互作用:遗传变异在PCOS风险和治疗反应中的作用

Polycystic Ovarian Syndrome Pub Date : 2019-08-29 DOI: 10.5772/intechopen.88698

R. Herman, M. Sever, A. Janež, V. Dolžan

{"title":"Interplay between Oxidative Stress and Chronic Inflammation in PCOS: The Role of Genetic Variability in PCOS Risk and Treatment Responses","authors":"R. Herman, M. Sever, A. Janež, V. Dolžan","doi":"10.5772/intechopen.88698","DOIUrl":"https://doi.org/10.5772/intechopen.88698","url":null,"abstract":"PCOS is often accompanied by insulin resistance, which is associated with the pathogenesis of the syndrome and increases the risk of developing the metabolic syndrome, type 2 diabetes, and cardiovascular complications. All these processes are characterized by chronic inflammation, which may be associated with an increased formation of reactive oxygen species and activation of inflammatory pathways that may further aggravate the function of pancreatic beta-cells. It has been shown that PCOS treatment improves metabolic indexes, while at the same time lowering inflammatory indicators. This chapter summarizes the latest findings about the role of oxidative stress and chronic inflammation in pathogenesis of PCOS. It also provides information on genetic variability in these pathways that may lead to interindividual differences in the risk for PCOS-related metabolic complications. Furthermore, genetic variability in these pathways may influence response to different treatment options in PCOS patients. a significant association between and polymorphism genotype in PCOS patients than in controls ( p 0.01) pathways and PCOS risk, clinical manifestations, or treatment response. Evidence shows that different genetic polymorphisms in those pathways have an important role in susceptibility for the development of PCOS and that they greatly influence its clinical manifestations. There is still a lack of studies that would evaluate how those polymorphisms affect individual treatment response. Large pharmacogenetic studies would improve our understanding of PCOS pathogenesis, and they could identify polymorphisms potentially used as a predictive biomarker for evaluating the risk for developing PCOS and for predicting treatment response in an individual patient.","PeriodicalId":20325,"journal":{"name":"Polycystic Ovarian Syndrome","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84910020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Roles of ncRNAs in Ovarian Dysfunction of Polycystic Ovary Syndrome ncrna在多囊卵巢综合征卵巢功能障碍中的作用

Polycystic Ovarian Syndrome Pub Date : 2019-08-07 DOI: 10.5772/INTECHOPEN.88314

Junyong Han, Zhen Yu, Gang Chen, Fan Wang

{"title":"Roles of ncRNAs in Ovarian Dysfunction of Polycystic Ovary Syndrome","authors":"Junyong Han, Zhen Yu, Gang Chen, Fan Wang","doi":"10.5772/INTECHOPEN.88314","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.88314","url":null,"abstract":"Polycystic ovary syndrome (PCOS) is a common endocrine disease in women of childbearing age. Many heterogeneous clinical manifestations of PCOS, including hyperandrogenism, obesity, insulin resistance, hirsutism, acne, chronic anovulation and infertility, seriously affected the quality of life of women worldwide and made it difficult to clearly demonstrate the specific pathophysiology. In recent years, large-scale studies have shown that non-coding RNAs (ncRNAs) play an important role in the regulation of ovarian functions, which did not have the ability to encode proteins and could regulate hormone synthesis and germ cell development, differentiation, and apoptosis by silencing transposable elements and regulating coding genes. A number of researches by whole transcriptome sequencing of polycystic ovaries (PCO) from PCOS patients or PCOS model animals found that the abnormal expressions of many ncRNAs were involved in the regulation of ovarian dys-functions of PCOS, including the development of oocytes, the microenvironment of follicular fluid, and the proliferation, differentiation, and apoptosis of granulosa cells. The present review focused on the roles of ncRNAs in the PCO of PCOS, in order to provide a theoretical basis for further understanding of the molecular mechanisms of PCO formation in PCOS.","PeriodicalId":20325,"journal":{"name":"Polycystic Ovarian Syndrome","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87732805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1