Concise Introduction to Basic Real Analysis最新文献

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Review of Set Theory 集合论述评
Concise Introduction to Basic Real Analysis Pub Date : 2019-08-12 DOI: 10.1201/9780429464676-1
H. Dutta, P. Natarajan, Y. Cho
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引用次数: 0
Differentiation 分化
Concise Introduction to Basic Real Analysis Pub Date : 2019-08-12 DOI: 10.1201/9780429464676-7
H. Dutta, P. Natarajan, Y. Cho
{"title":"Differentiation","authors":"H. Dutta, P. Natarajan, Y. Cho","doi":"10.1201/9780429464676-7","DOIUrl":"https://doi.org/10.1201/9780429464676-7","url":null,"abstract":"As circulating monocytes enter the site of disease, the local microenvironment instructs their differentiation into tissue macrophages (M Φ ). To identify mechanisms that regulate M Φ differentiation, we studied human leprosy as a model, since M1-type antimicrobial M Φ predominate in lesions in the self-limited form, whereas M2-type phagocytic M Φ are charac-teristic of the lesions in the progressive form. Using a heterotypic co-culture model, we found that unstimulated endothelial cells (EC) trigger monocytes to become M2 M Φ . How-ever, biochemical screens identified that IFN- γ and two families of small molecules activated EC to induce monocytes to differentiate into M1 M Φ . The gene expression profiles induced in these activated EC, when overlapped with the transcriptomes of human leprosy lesions, identified Jagged1 (JAG1) as a potential regulator of M Φ differentiation. JAG1 protein was preferentially expressed in the lesions from the self-limited form of leprosy, and localized to the vascular endothelium. The ability of activated EC to induce M1 M Φ was JAG1-dependent and the addition tuberculoid leprosy. These differences in the immune response can be characterized by the phenotype and activation state of the macrophage. We illustrate how the local endothelial microenvironment can “ educate ” macrophages, identifying Jagged1 and select small molecules that can regulate this pathway. Therefore, these studies identify a potential strategy to intervene in infection and inflammation, by targeting macrophage instruction at the site of disease. Through the integration of in vitro modeling and gene expression profiles at the site of disease, we found that Jagged 1 harnesses the endothelial microenvironment to instruct antimicrobial macrophage responses in leprosy.","PeriodicalId":202330,"journal":{"name":"Concise Introduction to Basic Real Analysis","volume":"67 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134349367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metric Spaces – Basic Concepts, Complete Metric Spaces 度量空间-基本概念,完整度量空间
Concise Introduction to Basic Real Analysis Pub Date : 2019-08-12 DOI: 10.1201/9780429464676-4
H. Dutta, P. Natarajan, Y. Cho
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引用次数: 0
Connectedness and Compactness 连通性和紧凑性
Concise Introduction to Basic Real Analysis Pub Date : 2019-08-12 DOI: 10.1007/0-387-22727-x_4
H. Dutta, P. Natarajan, Y. Cho
{"title":"Connectedness and Compactness","authors":"H. Dutta, P. Natarajan, Y. Cho","doi":"10.1007/0-387-22727-x_4","DOIUrl":"https://doi.org/10.1007/0-387-22727-x_4","url":null,"abstract":"","PeriodicalId":202330,"journal":{"name":"Concise Introduction to Basic Real Analysis","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114875563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sequences and Series of Real Numbers 实数序列与数列
Concise Introduction to Basic Real Analysis Pub Date : 2019-08-12 DOI: 10.1201/9780429464676-3
H. Dutta, P. Natarajan, Y. Cho
{"title":"Sequences and Series of Real Numbers","authors":"H. Dutta, P. Natarajan, Y. Cho","doi":"10.1201/9780429464676-3","DOIUrl":"https://doi.org/10.1201/9780429464676-3","url":null,"abstract":"","PeriodicalId":202330,"journal":{"name":"Concise Introduction to Basic Real Analysis","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123655601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integration 集成
Concise Introduction to Basic Real Analysis Pub Date : 2019-08-12 DOI: 10.1201/9780429464676-8
H. Dutta, P. Natarajan, Y. Cho
{"title":"Integration","authors":"H. Dutta, P. Natarajan, Y. Cho","doi":"10.1201/9780429464676-8","DOIUrl":"https://doi.org/10.1201/9780429464676-8","url":null,"abstract":"","PeriodicalId":202330,"journal":{"name":"Concise Introduction to Basic Real Analysis","volume":"18 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116090935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sequences and Series of Functions 函数的序列和级数
Concise Introduction to Basic Real Analysis Pub Date : 2019-08-12 DOI: 10.1201/9780429464676-9
H. Dutta, P. Natarajan, Y. Cho
{"title":"Sequences and Series of Functions","authors":"H. Dutta, P. Natarajan, Y. Cho","doi":"10.1201/9780429464676-9","DOIUrl":"https://doi.org/10.1201/9780429464676-9","url":null,"abstract":"","PeriodicalId":202330,"journal":{"name":"Concise Introduction to Basic Real Analysis","volume":"308 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123469087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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