PharmSciRN: Analytical Chemistry Techniques & Methods (Topic)最新文献

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A Study on Structural Characterization of Potential Impurities of Sugammadex Sodium Using LC/ESI/QTOF/MS/MS and NMR 用LC/ESI/QTOF/MS/MS和NMR表征糖madex钠潜在杂质的结构
PharmSciRN: Analytical Chemistry Techniques & Methods (Topic) Pub Date : 2021-10-01 DOI: 10.2139/ssrn.3856020
Senthil Kumar Pichandi Mohanraj, R. Tulasi, Venkatesan Chidambaram Subramanian, B. Dandu, Vinodh Guvvala, Srinivas Kota
{"title":"A Study on Structural Characterization of Potential Impurities of Sugammadex Sodium Using LC/ESI/QTOF/MS/MS and NMR","authors":"Senthil Kumar Pichandi Mohanraj, R. Tulasi, Venkatesan Chidambaram Subramanian, B. Dandu, Vinodh Guvvala, Srinivas Kota","doi":"10.2139/ssrn.3856020","DOIUrl":"https://doi.org/10.2139/ssrn.3856020","url":null,"abstract":"The first selective relaxant binding agent (SRBA), Sugammadex sodium (SGS) is used to reverse anesthesia. A study of the process related and degradation products will help to optimize process parameters and also to develop the analytical methods and set the quality standard for a quality control strategy in pharmaceutical industry. During the manufacture of SGS, all the process related impurities are controlled in every stage and process related and degradation products are controlled in the active pharmaceutical ingredient (API) as per ICH guidelines. A total of nine process related and degradation impurities of SGS (Impurity-A to Impurity-I) were isolated and characterized by using LC/ESI/QTOF/MS/MS and NMR studies.","PeriodicalId":19957,"journal":{"name":"PharmSciRN: Analytical Chemistry Techniques & Methods (Topic)","volume":"149 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73914303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
A Brief Review on the Reaction Mechanisms of Co2 Hydrogenation into Methanol Co2加氢制甲醇反应机理综述
PharmSciRN: Analytical Chemistry Techniques & Methods (Topic) Pub Date : 2020-01-01 DOI: 10.53894/ijirss.v3i2.31
Jawed Qaderi
{"title":"A Brief Review on the Reaction Mechanisms of Co2 Hydrogenation into Methanol","authors":"Jawed Qaderi","doi":"10.53894/ijirss.v3i2.31","DOIUrl":"https://doi.org/10.53894/ijirss.v3i2.31","url":null,"abstract":"The catalytic reduction of CO2 to methanol is an appealing option to reduce greenhouse gas concentration as well as renewable energy production. In addition, the exhaustion of fossil fuel, increase in earth temperature and sharp increases in fuel prices are the main driving factor for exploring the synthesis of methanol by hydrogenating CO2. Many studies on the catalytic hydrogenation of CO2 to methanol were published in the literature over the last few decades. Many of the studies have presented different catalysts having high stability, higher performance, low cost, and are immediately required to promote conversion. Understanding the mechanisms involved in the conversion of CO2 is essential as the first step towards creating these catalysts. This review briefly summarizes recent theoretical developments in mechanistic studies focused on using density functional theory, kinetic Monte Carlo simulations, and micro-kinetics modeling. Based on these simulation techniques on different transition metals, metal/metal oxide, and other heterogeneous catalysts surfaces, mainly, three important mechanisms that have been recommended are the formate (HCOO), reverse water–gas shift (RWGS), and trans-COOH mechanisms. Recent experimental and theoretical efforts appear to demonstrate that the formate route in which the main intermediate species is H2CO* in the reaction route, is more favorable in catalytic hydrogenation of CO2 to chemical fuels in various temperature and pressure conditions.","PeriodicalId":19957,"journal":{"name":"PharmSciRN: Analytical Chemistry Techniques & Methods (Topic)","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84540498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 29
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