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Expression of E-Cadherin in Epidermis from Wounds Treated with Costus afer Stem Juice Extract 木香茎汁提取物对伤口表皮e -钙粘蛋白表达的影响

Current Issue Pub Date : 2018-12-05 DOI: 10.33140/tapi/00006

引用次数: 1

The Influence of Statins on Bone Tissue in Ovariectomized Rats 他汀类药物对去卵巢大鼠骨组织的影响

Current Issue Pub Date : 2018-10-31 DOI: 10.33140/tapi/00007

Article, Seferos, G. Rallis, Kotsiou

{"title":"The Influence of Statins on Bone Tissue in Ovariectomized Rats","authors":"Article, Seferos, G. Rallis, Kotsiou","doi":"10.33140/tapi/00007","DOIUrl":"https://doi.org/10.33140/tapi/00007","url":null,"abstract":"Objectives: Osteoporosis is a silent, progressive, systemic skeletal disease characterized by impaired bone architecture\u0000with decreased bone mass density, affecting mainly women. Statins, inhibitors of HMG-CoA-reductase, seem to interfere\u0000with bone formation exerting anabolic and anti-resorptive effect. The aim of the present study is to investigate the\u0000effect of simvastatin on size parameters and bone density of mandible and femur, in an ovariectomized rat model of\u0000osteoporosis.\u0000Methods: 50 Wistar female rats were randomized in five groups (n=10). Groups 1, 2,3 were ovariectomized, 4 and\u00005 serve as controls. Groups 2, 3 and 5 were treated with simvastatin (0.5mg/kg/daily per os). Size parameters of the\u0000isolated femur, mandible and uterus, BMD via dual energy X-Ray absorptiometry (DEXA) and serum interleukin-13\u0000(IL-13) were estimated.\u0000Results: DEXA results showed significant decrease of BMD in ovariectomized group / controls while statins treatment\u0000decreased the severity of BMD lose. The serum IL-13, as osteogenesis index, seems to be positively influenced by\u0000statins treatment. Conclusions: Statins treatment seems to restore the decreased femur and mandible parameters and\u0000uterus weight in experimental menopause following ovariectomy.","PeriodicalId":196498,"journal":{"name":"Current Issue","volume":"104 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124135588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0