ISRN Biomarkers最新文献

Serum Ratio of Leptin to Adiponectin in Patients with Chronic Periodontitis and Type 2 Diabetes Mellitus 慢性牙周炎和2型糖尿病患者血清瘦素/脂联素比值的研究

ISRN Biomarkers Pub Date : 2014-01-12 DOI: 10.1155/2014/952636

X. Ling, M. Xin, He Lu, Wang Xian-e, Zhang Lin

引用次数: 4

Correlation between Body Mass Index and Thyroid Function in Euthyroid Individuals in Greece 希腊甲状腺功能正常人群体重指数与甲状腺功能的相关性

ISRN Biomarkers Pub Date : 2013-09-23 DOI: 10.1155/2013/651494

A. Milionis, C. Milionis

{"title":"Correlation between Body Mass Index and Thyroid Function in Euthyroid Individuals in Greece","authors":"A. Milionis, C. Milionis","doi":"10.1155/2013/651494","DOIUrl":"https://doi.org/10.1155/2013/651494","url":null,"abstract":"Although the effects of hypothyroidism and hyperthyroidism on body weight have been clearly demonstrated, there is no sufficient data on the relationship between the body mass index (BMI) and minor differences within the normal range of thyroid function. The present study aims to investigate the relationship of fluctuations of the thyroid stimulating hormone (TSH) and thyroid hormones with BMI in euthyroid subjects. The study included 736 euthyroid healthy individuals of known age, weight, height, and biochemical picture of the thyroid function. Individuals were classified according to BMI and thyroid hormones’ values. The variations of normal thyroid function in euthyroid individuals were associated with body weight changes. A statistically significant positive correlation between BMI and thyroid function in women was found, while in men the correlation was not statistically significant. The alterations in thyroid function are mainly primary, while changes in body weight are secondary. The reason may be simple or multifactorial, and the biological mechanism is not completely known. Finally, the thyroid function disorders in conjunction with the strong influence of various environmental factors can increase body weight and lead to obesity.","PeriodicalId":194012,"journal":{"name":"ISRN Biomarkers","volume":"190 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116395167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 44

Flow Cytometric Measurement of Aneuploid DNA Content Correlates with High S-Phase Fraction and Poor Prognosis in Patients with Non-Small-Cell Lung Cancer 流式细胞术检测非小细胞肺癌患者非整倍体DNA含量与高s期分数和不良预后相关

ISRN Biomarkers Pub Date : 2013-08-07 DOI: 10.1155/2013/354123

Rancés Blanco, Charles E. Rengifo, M. Cedeño, M. Frómeta, E. Rengifo

{"title":"Flow Cytometric Measurement of Aneuploid DNA Content Correlates with High S-Phase Fraction and Poor Prognosis in Patients with Non-Small-Cell Lung Cancer","authors":"Rancés Blanco, Charles E. Rengifo, M. Cedeño, M. Frómeta, E. Rengifo","doi":"10.1155/2013/354123","DOIUrl":"https://doi.org/10.1155/2013/354123","url":null,"abstract":"Cellular DNA content (ploidy) and proliferation activity (e.g., S-phase fraction) measured by flow cytometry have been usually related to the biologic aggressiveness of various neoplasms. In this study, these parameters were analyzed in paraffin-embedded tumor specimens from 43 cases of resected non-small-cell lung cancer (NSCLC). Additionally, the correlation of them with both prognosis and a variety of clinic-pathological features were investigated. The stage and the appearance of both local recurrence and metastasis were related to overall survival of patients. Twenty-two tumors (51.2%) had a diploid DNA distribution, while 21 were aneuploid (48.8%). The mean of aneuploidy was 1.6% ± 0.3%. A correlation was found between ploidy and survival as well as with the appearance of local recurrence and/or metastasis. The mean values of S-phase fraction of diploid and aneuploid tumors were 16.7 ± 11.3% and 32.9 ± 12.1%, respectively, which were significantly different (). Similar results were obtained analyzing the proliferation index (sum of cells in S and G2/M phases of cell cycle) (). However, no correlation between these parameters and both overall survival of patients and clinicopathological features was observed. Our results could suggest the potential use of ploidy analysis as a useful complement of TNM stage in NSCLC.","PeriodicalId":194012,"journal":{"name":"ISRN Biomarkers","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125376475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Short-Term Stability of Biomarkers of Oxidative Stress and Antioxidant Status in Human Serum 人血清中氧化应激和抗氧化状态生物标志物的短期稳定性

ISRN Biomarkers Pub Date : 2013-06-18 DOI: 10.1155/2013/316528

E. Jansen, P. Beekhof, J. Cremers, D. Vieželienė, V. Mužáková, J. Skalický

引用次数: 23

Diagnostically Relevant Molecular Markers in Head and Neck Neoplasms 头颈部肿瘤诊断相关分子标记

ISRN Biomarkers Pub Date : 2013-06-03 DOI: 10.1155/2013/873953

S. Varghese, P. Mathew, J. Jose

引用次数: 6

CD133 Staining Detects Acute Kidney Injury and Differentiates Clear Cell Papillary Renal Cell Carcinoma from Other Renal Tumors CD133染色检测急性肾损伤和鉴别透明细胞乳头状肾细胞癌与其他肾肿瘤

ISRN Biomarkers Pub Date : 2013-06-02 DOI: 10.1155/2013/353598

J. Schwartz, F. Dumler, J. Hafron, G. Wilson, S. C. Wolforth, M. Rooney, Wei Li, Ping L. Zhang

{"title":"CD133 Staining Detects Acute Kidney Injury and Differentiates Clear Cell Papillary Renal Cell Carcinoma from Other Renal Tumors","authors":"J. Schwartz, F. Dumler, J. Hafron, G. Wilson, S. C. Wolforth, M. Rooney, Wei Li, Ping L. Zhang","doi":"10.1155/2013/353598","DOIUrl":"https://doi.org/10.1155/2013/353598","url":null,"abstract":"CD133 has recently been characterized as a progenitor cell marker in the kidney. However, the expression of this marker has not been thoroughly investigated in kidney injury and variants of renal tumors for pathology practice. We quantified CD133 expression in kidney biopsies from patients with acute renal failure and compared staining intensity with serum creatinine levels. CD133 expression levels were also evaluated in several subtypes of renal neoplasms. Normal adult renal parenchyma showed CD133 expression in parietal epithelium and in less than 5% of the epithelial cells in proximal and distal nephron tubules. However, CD133 was diffusely upregulated in the injured proximal and distal tubular epithelium and the CD133 expression scores in renal tubules were significantly correlated with serum creatinine levels. Amongst the renal tumors, CD133 was diffusely expressed in clear cell papillary renal cell carcinoma but was only focally present in other types of renal tumors. In summary, CD133 is a useful marker to detect renal tubular injury and to differentiate clear cell papillary renal cell carcinoma from other tumor types.","PeriodicalId":194012,"journal":{"name":"ISRN Biomarkers","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124924423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9