Drug Discovery - Concepts to Market最新文献

In Vitro Biotransformation in Drug Discovery 药物发现中的体外生物转化

Drug Discovery - Concepts to Market Pub Date : 2018-09-19 DOI: 10.5772/INTECHOPEN.73173

S. Ravindran, Rutuja Rokade, J. Suthar, Pooja Singh, Pooja Deshpande, Rajeshree Khambadkar, Srushti Utekar

引用次数: 5

Bioinformatics Discovery of Vertebrate Cathelicidins from the Mining of Available Genomes 从可用基因组挖掘中发现脊椎动物抗菌肽的生物信息学研究

Drug Discovery - Concepts to Market Pub Date : 2018-09-19 DOI: 10.5772/INTECHOPEN.76631

J. D. L. Lastra, Cristina Garrido-Orduña, A. A. Borges, David Jíménez-Arias, Francisco J García-Machado, Mercedes Hernández, Concepción C. González, A. Boto

{"title":"Bioinformatics Discovery of Vertebrate Cathelicidins from the Mining of Available Genomes","authors":"J. D. L. Lastra, Cristina Garrido-Orduña, A. A. Borges, David Jíménez-Arias, Francisco J García-Machado, Mercedes Hernández, Concepción C. González, A. Boto","doi":"10.5772/INTECHOPEN.76631","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.76631","url":null,"abstract":"Due to the worrying increase in antimicrobial resistance to conventional antibiotics, the search for alternatives is becoming increasingly important. Antimicrobial peptides (AMPs), originating from natural resources, have been recognised as a novel class of antibiotics. An advantage of peptides over antibiotics is that the resistance is more difficult to attain than for conventional antibiotics. With the increasing number of genomes sequenced and available in the public domain, one alternative methodology to obtain novel AMPs is to analyse genes and proteins from genomic databases to predict and identify amino acid sequences that share similarities and molecular features with natural bioactive antimicrobial peptides. In this chapter, we summarise some of our recent results on the production of antimicrobial peptides, particularly, how we managed to identify a family of antimicrobial peptides: cathelicidins, through bioinformatics tools, from the genomes of two lower vertebrates (a reptile and a bird) available in public databases. We hope that our preliminary investigation with these novel peptides could be useful for the design of future strategies that pursue the production of antimicrobial peptides through biotechnology.","PeriodicalId":191867,"journal":{"name":"Drug Discovery - Concepts to Market","volume":"100 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115741285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Medicinal Plants of West Godavari 西哥达瓦里的药用植物

Drug Discovery - Concepts to Market Pub Date : 2018-09-19 DOI: 10.5772/INTECHOPEN.73499

S. Pola, Venkata Narasimha Kadali

{"title":"Medicinal Plants of West Godavari","authors":"S. Pola, Venkata Narasimha Kadali","doi":"10.5772/INTECHOPEN.73499","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.73499","url":null,"abstract":"Medicinal plants are one of the nature’s greatest gifts to the mankind. Each plant will have an exquisite deal of character, which can act as an antidote to various of diseases. Traditional medicine has become a vital alternative source of medicine all over the world today with some approximation of about 80% of the primary health care system in some developing countries. Medicinal plants are known to comprise of hundreds of active constituents that may be potentially useful for the development of therapeutic agents. The development of therapeutic agents involves the isolation and identifica - tion of bioactive compounds from plant materials which is crucial for drug discovery. Researchers from all around the globe have focused on drug discovery from the natures’ wonder medicinal plants, forming an important group of complementary and alternative medicine (CAM) therapy. West Godavari is a part of Andhra Pradesh, India, which hosts several plants that have high therapeutic significance. Each of the plants has a unique feature which can be employed for healing of various lethal diseases. The present examination intends to review the therapeutic plant assets of West Godavari area Andhra Pradesh. This evaluation also offers the critical elements which include medicinal properties of various medicinal plants found in West Godavari district of Andhra Pradesh, India.","PeriodicalId":191867,"journal":{"name":"Drug Discovery - Concepts to Market","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116662990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Cell-Based Screening to Identify Cytoprotective Compounds 基于细胞筛选鉴定细胞保护化合物

Drug Discovery - Concepts to Market Pub Date : 2018-09-19 DOI: 10.5772/INTECHOPEN.73172

Domokos Gerő

{"title":"Cell-Based Screening to Identify Cytoprotective Compounds","authors":"Domokos Gerő","doi":"10.5772/INTECHOPEN.73172","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.73172","url":null,"abstract":"Prevention of cellular injury and consequent cell death is expected to provide therapeutic benefit in various diseases, but with the complexity of cell damaging pathways involved, identification and validation of novel potential drug targets is not a trivial task. New drug targets are expected to take part in complex responses with wide-ranging effects on gene expression and cellular function and drug candidates rather modify these effects than act as simple agonists or antagonists to ultimately protect the cells from an injury. Phenotypic screening may help identify cytoprotective compounds in diseases, in which the lack of drug targets makes target-based approaches unfeasible. This chapter gives an overview of the strategy of cell-based assay development, primary screening, hit selection and confirmation. Considerations about the choice of small molecule compound libraries utilized in cell-based models are discussed as well as the use of clinical drugs for drug repurposing or repositioning. The choice of cell types and issues associated with cell culture techniques are overviewed and the most common assays and readouts are briefly described. Finally, the potential pitfalls of data analysis and hit selection are discussed.","PeriodicalId":191867,"journal":{"name":"Drug Discovery - Concepts to Market","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126486405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

On the Organization of a Drug Discovery Platform 论药物发现平台的组织

Drug Discovery - Concepts to Market Pub Date : 2018-09-19 DOI: 10.5772/INTECHOPEN.73170

J. Boutin, O. Nosjean, G. Ferry

引用次数: 1

Biomedical and Pharmaceutical Applications of Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) 电感耦合等离子体质谱(ICP-MS)在生物医学和制药领域的应用

Drug Discovery - Concepts to Market Pub Date : 2018-09-19 DOI: 10.5772/INTECHOPEN.74787

D. N. Reddy, A. J. Al-Rajab, G. Reddy

{"title":"Biomedical and Pharmaceutical Applications of Inductively Coupled Plasma-Mass Spectrometry (ICP-MS)","authors":"D. N. Reddy, A. J. Al-Rajab, G. Reddy","doi":"10.5772/INTECHOPEN.74787","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.74787","url":null,"abstract":"Medical science is a field of study that is relevant to all people, but the development of pharmaceutical, biomedical and life science is of particular importance. In these fields, further studies are being established to determine with incredible accuracy the quantities and concentration of inorganic elements and organic compounds, such as nucleotides, sulphur and phosphorous containing peptides and proteins, to be used in all kinds of drugs. Since 1980, inductively coupled plasma-mass spectrometry (ICP-MS) has emerged as a new and powerful technique for elemental and isotopic analysis. It provides a means for the analysis of an extremely wide range of elements and the co-analysis of most elements in the periodic table. It can also be used for qualitative, quantitative and semi- quantitative analysis and for the measurement of isotopic ratios through mass-to-charge ratios. In recent years, ICP-MS has emerged as the best technique for the quantification of inorganic impurities in pharmaceutical and biomedical applications. This chapter focuses on introducing the applications of ICP-MS in the pharmaceutical and biomedical fields. Some problems facing ICP-MS are also presented at the end of this chapter.","PeriodicalId":191867,"journal":{"name":"Drug Discovery - Concepts to Market","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129864418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Pharmacologic Interventions for Preventing Chondrocyte Apoptosis in Rheumatoid Arthritis and Osteoarthritis 预防类风湿关节炎和骨关节炎软骨细胞凋亡的药物干预

Drug Discovery - Concepts to Market Pub Date : 2018-09-19 DOI: 10.5772/INTECHOPEN.73174

C. Malemud

{"title":"Pharmacologic Interventions for Preventing Chondrocyte Apoptosis in Rheumatoid Arthritis and Osteoarthritis","authors":"C. Malemud","doi":"10.5772/INTECHOPEN.73174","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.73174","url":null,"abstract":"Chronic inflammation drives the progression of rheumatoid arthritis (RA) and osteo - arthritis (OA) to synovial joint failure. The inflammatory state in both musculoskeletal diseases is associated with significantly elevated levels of pro-inflammatory cytokines in joint synovial fluid, which is best exemplified by increases in interleukin-1β (IL-1β), IL-6, IL-17, tumor necrosis factor-α, among others, as well as increased activity of soluble mediators such as nitric oxide and certain growth factors including vascular endothe lial growth factor and fibroblast growth factor. The multitude of these factors activate chondrocyte signal transduction pathways resulting in programmed cell death, other wise known as apoptosis as well as compromising chondrocyte autophagy. Importantly, chondrocyte apoptosis causes a loss of articular cartilage vitality which dampens carti lage repair mechanisms because at present, the possibility that chondrocyte progenitor cells could replace those differentiated chondrocytes lost via apoptosis remains debat -able. Certain pharmacologic interventions which have been proven to induce apoptosis in various cancer cell studies in vitro suggest the possibility that drugs could be devel oped to specifically suppress or completely inhibit chondrocyte apoptosis in RA and OA cartilage. This review supports that contention and indicates that apoptosis can be inhibited by identifying novel cellular targets which promote apoptosis and autophagy.","PeriodicalId":191867,"journal":{"name":"Drug Discovery - Concepts to Market","volume":"97 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133192649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Drug Treatment of Obesity: From Bench to Bedside 肥胖的药物治疗:从实验室到床边

Drug Discovery - Concepts to Market Pub Date : 2018-02-09 DOI: 10.5772/INTECHOPEN.73559

J. Jakab, R. Smolić, A. Včev, M. Smolić

引用次数: 2