Prime Archives in Immunology最新文献

{"title":"Diphtheria Position of Laboratory and Improvement of New Diagnostic Assays","authors":"S. De-Simone, L. R. Gomes, G. Lechuga, Paloma Napoleão-Pêgo, D. W. Provance-Jr, F. D. Silva","doi":"10.37247/paimmu2ed.2.2021.16","DOIUrl":"https://doi.org/10.37247/paimmu2ed.2.2021.16","url":null,"abstract":"","PeriodicalId":188401,"journal":{"name":"Prime Archives in Immunology","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127842156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crotalus Durissus Ruruima Current Knowledge on Natural History, Medical Importance, and Clinical Toxinology","authors":"M. Pucca, P. Bernarde, A. M. Rocha, P. Viana, Raimundo Erasmo Souza Farias, F. Cerni, I. Oliveira, I. Ferreira, E. A. Sandri, Jacqueline A G Sachett, F. H. Wen, V. Sampaio, A. H. Laustsen, M. A. Sartim, W. Monteiro","doi":"10.37247/paimmu2ed.2.2021.17","DOIUrl":"https://doi.org/10.37247/paimmu2ed.2.2021.17","url":null,"abstract":"Citation: Pucca MB, Bernarde PS, Rocha AM, Viana PF, Farias RES, Cerni FA, Oliveira IS, Ferreira IG, Sandri EA, Sachett J, Wen FH, Sampaio V, Laustsen AH, Sartim MA and Monteiro WM (2021) Crotalus Durissus Ruruima: Current Knowledge on Natural History, Medical Importance, and Clinical Toxinology. Front. Immunol. 12:659515. doi: 10.3389/fimmu.2021.659515 REVIEW published: 08 June 2021 doi: 10.3389/fimmu.2021.659515","PeriodicalId":188401,"journal":{"name":"Prime Archives in Immunology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131148565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune Landscape in the Inflamed Colonic Mucosa of Patients with IBD","authors":"Hong Liu, S. Dasgupta, Yu Fu, Brandi Bailey, C. Roy, E. Lightcap, B. Faustin","doi":"10.37247/pai.1.2020.7","DOIUrl":"https://doi.org/10.37247/pai.1.2020.7","url":null,"abstract":"Background: Myeloid cells, and dendritic cells (DC), play vital roles in innate immunity, and in the initiation and maintenance of adaptive immunity. While T cell-associated activation pathways and cytokines have been identified and evaluated in inflammatory bowel disease (IBD) patients [1] , the role of mononuclear phagocytes are less understood. Recent reports support the crucial role of DC subsets in the development of acute colitis models [2] and suggest they may contribute to the pathogenesis of ulcerative colitis (UC) by inducing Th1/Th2/Th17 responses [3]. Results: We performed in silico analysis and evaluated the enrichment of immune cells, with a focus on mononuclear phagocytes in IBD patient colonic biopsies. Samples were from different gut locations, with different levels of disease severity, and with treatment response to current therapies. We observe enrichment of monocytes, M1 macrophages, activated DCs (aDCs) and plasmacytoid dendritic cells (pDCs) in inflamed tissues from various gut locations. This enrichment correlates with disease severity. Additionally, the same mononuclear phagocytes subsets are among the top enriched cell types in both infliximab and vedolizumab treatment non-responder samples. We further investigated the enrichment of selected DC and monocyte subsets based on gene signatures derived from a DC-and monocyte-focused single cell RNA-seq (scRNA-seq) study [4], and verified enrichment in both inflamed tissues and those with treatment resistance. Moreover, we validated an increased mononuclear phagocyte subset abundance in a Dextran Sulphate Sodium (DSS) induced colitis model in C57Bl/6 mice representative of chronic inflammation. Conclusions: We conducted an extensive analysis of immune cell populations in IBD patient colonic samples and identified enriched subsets of monocytes, macrophages and dendritic cells in inflamed tissues. Understanding how they interact with other immune cells and other cells in the colonic microenvironment such as epithelial and stromal cells will help us to delineate disease pathogenesis.","PeriodicalId":188401,"journal":{"name":"Prime Archives in Immunology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114064903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunologic Abnormalities in β-Thalassemia","authors":"Ch. D.Asadov","doi":"10.37247/pai.1.2020.1a","DOIUrl":"https://doi.org/10.37247/pai.1.2020.1a","url":null,"abstract":"","PeriodicalId":188401,"journal":{"name":"Prime Archives in Immunology","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125326367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary Polyunsaturated Fatty Acids and Cellular Immune Response in Broiler Chickens","authors":"H. Al-Khalaifah, A. Al-Nasser, T. Al-Surrayai","doi":"10.37247/PAIMMU2ED.2.2021.6","DOIUrl":"https://doi.org/10.37247/PAIMMU2ED.2.2021.6","url":null,"abstract":"immune organ weights as a general indicator, haemocytometric measurements, intestinal microbial count and hindgut acidosis, hindgut volatile fatty acids, and cellular immune response using PHA-test. The use of the different dietary treatments did not affect the general health status of the chickens and the mortality was minimal with no signs of illness or outbreaks. At 3-wk of age, there was no significant effect observed in the microbial counts of the intestine. However, at 5-wk of age, the highest microbial count was significantly observed for broilers fed EO (7.30%), closely followed by SFO (6.95%) and the least microbial counts were observed for CO (5.63%). No significance was observed for LAB and Salmonella. There was no significance observed for the effect of the dietary treatments on the hindgut volatile acid in the broilers. Wattle swelling changes were significant between dietary treatments. The results revealed that dietary FLO, FO, and DHA oils induced higher cellular response than the other treatments ( P =0.035), representing higher cellular response in these groups. In conclusion, supplemental oils rich in n-3 fatty acids may enhance the immune response in broiler chickens, represented by the intestinal microbial counts and the cellular immune response.","PeriodicalId":188401,"journal":{"name":"Prime Archives in Immunology","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129125194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}