Archives of Hepatitis Research最新文献

{"title":"The association with histopathological findings and predictive significance of transforming growth factor beta 1 (TGF β1) in patients with chronic viral hepatitis","authors":"Bugdaci Mehmet Sait, Karaca Cetin, Koksal Ali Rıza, Boga Salih, Alkim Canan, Sokmen Mehmet","doi":"10.17352/ahr.000035","DOIUrl":"https://doi.org/10.17352/ahr.000035","url":null,"abstract":"Background: Chronic Viral Hepatitis (CVH) is the most common cause of hepatocellular cancer and cirrhosis related to liver fibrosis. The gold standard in the diagnosis of fibrosis is liver biopsy. TGF β1 is a pleiotropic cytokine that plays a pivotal role in carcinogenesis and fibrosis. The results of studies investigating the relationship between TGF β1 and histopathological findings are controversial. We aimed to investigate the relationship between TGF β1 and histopathological findings. Methods: Patients with Chronic Hepatitis B (CHB) and C (CHC), Non-Alcoholic Steatohepatitis (NASH), inactive HBsAg carriers, patients with cirrhosis and healthy control cases presenting to the Gastroenterology Clinic of Sisli Etfal Training and Research Hospital between 2009-2010 were included in the study. Laboratory tests, HCV RNA, HBV DNA, viral load, and viral markers (such as HBsAg, anti-HCV) were determined. Biopsies were performed on patients with hepatitis B and C, and non-alcoholic steatohepatitis (NASH). Histologic features were defined as Histologic Activity Index (HAI) and fibrosis stage (Knodell’s scoring). TGF β1 was evaluated by the ELISA method. Results: 267 cases including 44 non-alcoholic steatohepatitis cases [27 female (57%)], 38 inactive HBsAg carriers [23 female (60%)], 48 patients with chronic hepatitis B [17 female (35%)], 27 chronic hepatitis C [14 female (60%)], 15 decompensated cirrhosis [3 female (20%)] and 94 healthy control cases were included in the study. Compared with healthy controls, all other subgroups had significantly elevated TGF β1 levels. TGF β1 was found to have a specificity of 93.6% and a sensitivity of 88.9% (AUC: 0.948, 95% CI: 0.916-0.981) in determining liver diseases. TGF β1 had a positive correlation with fibrosis and histological activity index in patients with CHB and CHC. There was a negative correlation between TGF β1 and HBV DNA and HCV RNA. TGF β1 had a significant correlation with LDL and total cholesterol in cases with CHB and CHC. Conclusion: TGF β1 is correlated with both HAI and fibrosis in patients with CHB and CHC. TGF β1 might have a role in the prognostic significance of elevated LDL levels and low viral load in patients with CHC.","PeriodicalId":187565,"journal":{"name":"Archives of Hepatitis Research","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127009652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Viral hepatitis B in patients with hematological malignancies (Overview)","authors":"Sidorkevich Sv, Chebotkevich Vn, Kuleshov Av, Kajtandzhan Ei, Bessmel'tsev Ss","doi":"10.17352/ahr.000034","DOIUrl":"https://doi.org/10.17352/ahr.000034","url":null,"abstract":"The review presents current data on the role of viral hepatitis B in oncohematological patients. Possible ways of infection, prevention of infection, and activation of hepatitis B in this category of patients are considered. The specific features of the course of hepatitis B in various clinical situations are described: against the background of other viral infections and in the conduct of specific anti-leukemia therapy.","PeriodicalId":187565,"journal":{"name":"Archives of Hepatitis Research","volume":"87 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131945547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bio-informatics approaches in liver disease: Incomplete without experimental validation","authors":"Gaur Pratibha","doi":"10.17352/ahr.000033","DOIUrl":"https://doi.org/10.17352/ahr.000033","url":null,"abstract":"In the search for the treatment of hepatic diseases, multiple approaches have been used frequently such as bioinformatics and algorithm-based systems biology for the screening of already published data that leads to the identification of promising drug candidates at molecular levels. These studies provide a large data set of information and claim to identify many genes, which could be targeted for the cure. However, it is important to note that the identified compounds are only predictions and the potential of these suggested molecules or genes should be well confirmed by adopting robust and critical experimental approaches to satisfy all possible aspects to use them safely for therapeutic purposes. Therefore, I put forward the opinion that these predicted markers whether prognostic, diagnostic, or molecular must be evaluated critically through a well-defined experimental pipeline.","PeriodicalId":187565,"journal":{"name":"Archives of Hepatitis Research","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122571921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The dark proteome of rodent hepatitis E virus: Analysis of intrinsically disordered regions","authors":"Shafat Zoya, Ahmed E. Anwar, P. Mohammad K., Islam Asimul, Parveen Shama","doi":"10.17352/ahr.000032","DOIUrl":"https://doi.org/10.17352/ahr.000032","url":null,"abstract":"Hepatitis E virus (HEV) is the causative agent of Hepatitis E infections across the world. Intrinsically disordered protein regions (IDPRs) or Intrinsically Disordered Protein (IDPs) are regions or proteins that are characterized by a lack of definite structure. These regions or proteins play significant roles in a wide range of biological processes, such as cell cycle regulation, control of signaling pathways, etc. IDPRs or IDPs in proteins are associated with the virus’s pathogenicity and infectivity. The occurrence of intrinsic disorder in the proteome of rat HEV remains to be elucidated, which prompted us to explore its dark proteome. In this study, the unstructured/disordered regions of ORF proteins of rat HEV have been examined. We have analyzed the prevalence of intrinsic disorder by using a set of computational predictors. The intrinsic disorder propensity analysis showed that the ORF proteins consisted of a varying fraction of intrinsic disorder. The ORF3 protein was identified with a maximum propensity for intrinsic disorder while the protein ORF6 showed the least propensity for the intrinsic disorder. Further, the analysis revealed ORF6 as highly structured protein (ORDP); ORF1 and ORF4 as moderately disordered proteins (IDPRs); and ORF3 and ORF5 as highly disordered proteins, categorizing them as ordered protein (ORDP), a protein having Intrinsically Disordered Region (IDPR) and Intrinsically Disordered Proteins (IDP) respectively. Such disordered regions may play several important roles in the pathogenesis and replication of viruses. Collectively, this comprehensive study data from our investigation suggested ORF protein’s role in the regulation and pathogenesis of rat herpesvirus.","PeriodicalId":187565,"journal":{"name":"Archives of Hepatitis Research","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134092393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of hepatitis B virus infection among persons with hepatitis D virus and diabetes mellitus in Pakistan, 2019-2021","authors":"R. Ahmad, Mazhar Muhammad Waqar, Saif Saira, Sikandar Mudasara, Mehmood Javaria, Iram Wajeeha, Tahir Hira, Noor Shanzab, Mazhar Fatima","doi":"10.17352/ahr.000031","DOIUrl":"https://doi.org/10.17352/ahr.000031","url":null,"abstract":"Introduction: The HBV virus has its enveloped protein that surrounds nucleic acid for its protection. Hepatitis B DNA virus belongs to the Hepadnoviridae family and is similar to retroviruses. Globally, HBV infected people approximately 2 billion in the world, about 350 million people were chronic carriers. One million deaths are caused by the HBV virus every year. Each year, 400,000 new cases were reported in Latin America. Among all over the World, Pakistan was considered as one of the largest chronic viral hepatitis infection countries. Methodology: 975 samples were recoded from different districts of south Punjab. The sera of the patient’s sample were examined to analyze the LFTs, HBS serology, HBS ELIZA, anti-HBeAg, AFP, anti- HDV, HBC IgM, and HBV DNA EAL TIME PCR. An anticoagulant sample was used to analyze their prothrombin time, HB level, WBC count, PLT counts, and HBA1C. Data were analyzed by using Microsoft Excel 2019 and SPSS version 14.0. Results: 975 samples were collected from the Multan district of Punjab. Out of which 638(65.43%) patients were detected positive for HBsAg serology, 312(32.84%) were not detected. The HBA1C test values are higher in HBV patients and its normal value is below 6.4%. In 1st group 258 patients out of 638 are HBV PCR DETECTED, bilirubin 2.1+-5.7, ALP 425.1±575.1, AST 119.6±102.6, ALT 62.0±41.6, and albumin 3.5±0.9. in the 2nd group, 149 patients out of 638 are HBV PCR detected, bilirubin 1.4±1.9, ALP 488.1±339.2, AST 143.0±117.4, ALT 78.1±53.4, and albumin 4.4±0.6. Conclusion: The prevalence of HBV in diabetic patients is higher as compared to control diabetic patients. the patients with high serum AFP levels tend to be HBs-Ag-positive, and those who have low AFP levels are associated with cryptogenic cirrhosis. The positive HBc IgM is higher in anti-HDV-negative cases as compared to HDV-positive cases. The value of HBV DNA was higher in anti-HDV-negative cases. The HBsAg correlates with HBV DNA level and it’s a level higher in the IT phase and lowers in the IC phase.","PeriodicalId":187565,"journal":{"name":"Archives of Hepatitis Research","volume":"130 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122510415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seroprevalence and associated risk factors for Hepatitis B Virus infections among apparently healthy pregnant mothers attending Anc in Rubkona primary health care center in Rubkona County, Unity State, South Sudan","authors":"Michael Pou Machar, Dube Jara","doi":"10.17352/AHR.000029","DOIUrl":"https://doi.org/10.17352/AHR.000029","url":null,"abstract":"Background: Hepatitis B is an infection caused by the Hepatitis B Virus (HBV), which is enveloped DNA virus that infects the liver, and the common complications are; cirrhosis, liver cancer and rest of organs failure.","PeriodicalId":187565,"journal":{"name":"Archives of Hepatitis Research","volume":"121 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123111849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatic involvement in COVID 19 infection","authors":"Paul Jayanta","doi":"10.17352/ahr.000027","DOIUrl":"https://doi.org/10.17352/ahr.000027","url":null,"abstract":"Background: Severe Acute Respiratory Distress Syndrome Coronavirus -2 (SARS -CoV-2) outbreak is a significant public health threat since December 2019. Lung is the most common organ involved by COVID 19 followed by gastrointestinal tract and liver. This review article discusses hepatic involvement and monitoring in this outbreak. \u0000Methods: Recently published studies from PubMed, Red Cross, and Copernicus were reviewed to prepare this review article. \u0000Conclusions: Hepatic involvement is common in COVID 19 infection and it is the second most common organ involved after lung. Most of the hepatic involvements are mild and self limiting. However close monitoring is required.","PeriodicalId":187565,"journal":{"name":"Archives of Hepatitis Research","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124774539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Viral Hepatitis in India","authors":"S. Kishanrao","doi":"10.17352/ahr.000026","DOIUrl":"https://doi.org/10.17352/ahr.000026","url":null,"abstract":"Viral hepatitis is a cause for major health care burden in India and is recently equated as a threat comparable to the “big three” communicable diseases – HIV/AIDS, Malaria, and Tuberculosis. Hepatitis A virus and Hepatitis E virus are predominantly enterically transmitted pathogens and are responsible to cause both sporadic infections and epidemics of acute viral hepatitis. Hepatitis B virus and Hepatitis C virus are predominantly spread via parenteral route and are notorious to cause chronic hepatitis which can lead to grave complications including cirrhosis of liver and hepatocellular carcinoma.","PeriodicalId":187565,"journal":{"name":"Archives of Hepatitis Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116221198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occult Hepatitis B Virus infection in a cohort of patients with chronic Hepatitis C","authors":"M. Naga, M. Amin, Dina Algendy, AI El Badry, M. Fawzi, AR Foda, S. Esmat, S. Gabal, Dina Sabry, M. Kamal, L. Rashed","doi":"10.17352/AHR.000022","DOIUrl":"https://doi.org/10.17352/AHR.000022","url":null,"abstract":"Introduction: The prevalence of occult hepatitis B, defi ned by absence of HBsAg and HBV DNA, \u0000ranges widely in patients with hepatitis C. This may infl uence the treatment of hepatitis C and the severity \u0000of liver disease","PeriodicalId":187565,"journal":{"name":"Archives of Hepatitis Research","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125244665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experience with Hepatitis B Viral load Testing in Jharkhand","authors":"Sana Irfan, M. Gupta, N. P. Sahu, Zulfiquar Ali Bhuttoo, Poonam Kumari","doi":"10.17352/AHR.000021","DOIUrl":"https://doi.org/10.17352/AHR.000021","url":null,"abstract":"Quantification of the viral burden is an important laboratory tool in the management of hepatitis B virus (HBV)-infected patients. However, widespread use of assays is still hampered due to the high cost.","PeriodicalId":187565,"journal":{"name":"Archives of Hepatitis Research","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115309853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}