Photodynamic Therapy - From Basic Science to Clinical Research最新文献

Photodynamic Treatment of Staphylococcus aureus Infections 金黄色葡萄球菌感染的光动力治疗

Photodynamic Therapy - From Basic Science to Clinical Research Pub Date : 2021-02-01 DOI: 10.5772/INTECHOPEN.95455

C. Palavecino, Camila Pérez, Tania Zúñiga

{"title":"Photodynamic Treatment of Staphylococcus aureus Infections","authors":"C. Palavecino, Camila Pérez, Tania Zúñiga","doi":"10.5772/INTECHOPEN.95455","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.95455","url":null,"abstract":"Introduction: Staphylococcus aureus is a Gram-positive coconut that causes various life-threatening infections and, in turn, represents a major producer of healthcare-associated infections. This pathogen is highly resistant to antibiotics, which has made it difficult to eradicate in recent decades. Photodynamic therapy is a promising approach to address the notable shortage of antibiotic options against multidrug-resistant Staphylococcus aureus. This therapy combines the use of a photosensitizing agent, light, and oxygen to eradicate pathogenic microorganisms. The purpose of this study is to provide relevant bibliographic information about the application of photodynamic therapy as an alternative antimicrobial therapy for Staphylococcus aureus infections. Methods: This review was achieved through a bibliographic search in various databases and the analysis of relevant publications on the subject. Results: A large body of evidence demonstrates the efficacy of photodynamic therapy in eliminating biofilm- or biofilm-producing strains of Staphylococcus aureus, as well as antibiotic-resistant strains. Conclusion: We conclude that photodynamic therapy against Staphylococcus aureus is a recommended antibacterial therapy that may complement antibiotic treatment.","PeriodicalId":186059,"journal":{"name":"Photodynamic Therapy - From Basic Science to Clinical Research","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123773637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Nanomaterials for Enhanced Photodynamic Therapy 用于增强光动力治疗的纳米材料

Photodynamic Therapy - From Basic Science to Clinical Research Pub Date : 2020-11-06 DOI: 10.5772/intechopen.94255

L. F. Freitas

引用次数: 5

Synergic Influence of Parameters Involved in the Polymeric Nanoparticle Preparation on the Efficacy of Photodynamic Therapy 聚合物纳米颗粒制备过程中相关参数对光动力治疗效果的协同影响

Photodynamic Therapy - From Basic Science to Clinical Research Pub Date : 2020-11-03 DOI: 10.5772/intechopen.94176

Barbara Silva Figueiredo, Julyana Noval de Souza Ferreira, Vannyla Viktória Viana Vasconcelos, P. Souza, Rafaela Vergna De Angeli, A. R. Silva

{"title":"Synergic Influence of Parameters Involved in the Polymeric Nanoparticle Preparation on the Efficacy of Photodynamic Therapy","authors":"Barbara Silva Figueiredo, Julyana Noval de Souza Ferreira, Vannyla Viktória Viana Vasconcelos, P. Souza, Rafaela Vergna De Angeli, A. R. Silva","doi":"10.5772/intechopen.94176","DOIUrl":"https://doi.org/10.5772/intechopen.94176","url":null,"abstract":"The challenge was always great for lipophilic photosensitizer use in the photodynamic therapy (PDT) for treatment of internal body diseases. Photosensitizer metabolism in liver, incompatibility of the molecules in the gastric acid, aggregation in the bloodstream, opsonization of molecules and phagocyting process hamper the application of the free lipophilic photosensitizer in disease treatment using PDT. This problem has been partially resolved using the drug delivery system to encapsulate the photosensitizer. Many studies have been reported using polymeric nanoparticles to encapsulate the lipophilic photosensitizer showing excellent results for PDT, but few nanoparticulate formulations are available at the pharmacies. The absence of deep knowledge about the influence of synergic effect of parameters used in the nanoparticle preparation on its properties, the photobleaching process of encapsulated photosensitizer and the molecule aggregation into the nanoparticle can decrease the photodynamic efficacy for the lipophilic photosensitizer. Our research group has studied the influence of many parameters on the nanoparticulate properties of several encapsulated phthalocyanines and porphyrin using factorial design, evaluating the free and encapsulated compound aggregation, efficacy to reduce the viability of cancer cells, the photooxidation of the biomolecules and the influence of photobleaching. This work shows the most important results to be consider in the optimization of the polymeric nanoparticle.","PeriodicalId":186059,"journal":{"name":"Photodynamic Therapy - From Basic Science to Clinical Research","volume":"72 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128766740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Application of Photodynamic Therapy in the Treatment of Osteonecrosis of the Jaw 光动力疗法在颌骨骨坏死治疗中的应用

Photodynamic Therapy - From Basic Science to Clinical Research Pub Date : 2020-10-28 DOI: 10.5772/intechopen.94257

M. Vuletić, B. L. Brzak, I. Smojver, L. Marković, M. Sušić, D. Gabrić

{"title":"Application of Photodynamic Therapy in the Treatment of Osteonecrosis of the Jaw","authors":"M. Vuletić, B. L. Brzak, I. Smojver, L. Marković, M. Sušić, D. Gabrić","doi":"10.5772/intechopen.94257","DOIUrl":"https://doi.org/10.5772/intechopen.94257","url":null,"abstract":"Osteonecrosis as term represents the death of bone tissue in the body and causes of necrosis can be different. Medication-related osteonecrosis of the jaws (MRONJ) is nowadays known as an inability of the alveolar bone to respond to a local trauma and it can result in severe local and systemic complications. In the etiology of medication-related osteonecrosis there are antiangiogenic and antiresorptive agents which have great effect on alveolar bone, producing an imbalance between resorption (osteoclastic activity) and deposition (osteoblastic activity). The exact mechanisms of development are not todays completely resolved. It is thought that it is a result from combination of medication interactions, microbiological contamination of the area and local tissue trauma. Typical signs and symptoms are painful mucosal lesions, swelling, exposed necrotic bone in the jaws, discomfort and dysesthesias. There is currently no gold standard or clearly defined treatment protocol for the disease itself. Process of treatment is demanding and main goal is to eliminate pain, control infection of soft and hard tissue and minimize progression of osteonecrosis. Besides the conventional surgical treatment, photodynamic therapy can be a viable supportive tool of initial and advanced stages of osteonecrosis and may contribute to improvements of patient′s quality of life.","PeriodicalId":186059,"journal":{"name":"Photodynamic Therapy - From Basic Science to Clinical Research","volume":"05 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130196613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anatomically Adjustable Device for Large-Area Photodynamic Therapy 解剖可调大面积光动力治疗装置

Photodynamic Therapy - From Basic Science to Clinical Research Pub Date : 2020-10-14 DOI: 10.5772/intechopen.93917

A. Fujita, Daniel José Chianfrome, Vinicius Sigari Moreira, A. Zanchin, P. F. Menezes, V. Bagnato

引用次数: 1

Evaluation of the Antimicrobial Efficacy of Different Types of Photodynamic Therapy on the Main Pathogenic Bacteria of Peri-Implantitis 不同类型光动力疗法对种植体周围炎主要致病菌抗菌效果的评价

Photodynamic Therapy - From Basic Science to Clinical Research Pub Date : 1900-01-01 DOI: 10.5772/intechopen.94268

D. Gabrić, Ana Budimir, I. Bago, L. Marković, Verica Pavlić, Bleron Azizi

引用次数: 2