Luca Spiezia, Elena Campello, Marco Cola, Francesco Poletto, Lorenzo Cerruti, Anna Poretto, Chiara Simion, Annamaria Cattelan, Roberto Vettor, Paolo Simioni
{"title":"More severe hypercoagulable state in acute COVID-19 pneumonia as compared to other pneumonia.","authors":"Luca Spiezia, Elena Campello, Marco Cola, Francesco Poletto, Lorenzo Cerruti, Anna Poretto, Chiara Simion, Annamaria Cattelan, Roberto Vettor, Paolo Simioni","doi":"10.1016/j.mayocpiqo.2020.08.014","DOIUrl":"10.1016/j.mayocpiqo.2020.08.014","url":null,"abstract":"<p><strong>Objective: </strong>To conduct a comprehensive evaluation of coagulation profiles - via traditional and whole blood thromboelastometry tests - in COVID-19 positive vs. COVID-19 negative patients admitted to medical wards for acute pneumonia.</p><p><strong>Patients and methods: </strong>We enrolled all consecutive patients admitted to Internal Medicine wards of Padova University Hospital between 7 March and 30 April 2020 for COVID-19-related pneumonia (cases) vs. non-COVID-19 pneumonia (controls). A group of healthy subjects acted as baseline for thromboelastometry parameters.</p><p><strong>Results: </strong>Fifty-six cases (mean age 64±15 yrs, M/F 37/19) and 56 controls (mean age 76±11 yrs, M/F 35/21) were enrolled. Cases and controls showed markedly hypercoagulable thromboelastometry profiles vs. healthy subjects, mainly characterized by a significantly shorter propagation phase of coagulation (Clot Formation Time, CFT) and significantly increased maximum clot firmness (MCF) (p <0.001 in all comparisons). COVID-19 patients with pneumonia had significantly shorter CFT and higher MCF (p <0.01 and <0.05, respectively in all comparisons) vs. controls.</p><p><strong>Conclusion: </strong>Patients admitted to internal medicine wards for COVID-19 pneumonia presented a markedly prothrombotic state, which seems peculiar to COVID-19 rather than pneumonia itself.</p>","PeriodicalId":18378,"journal":{"name":"Mayo Clinic Proceedings: Innovations, Quality & Outcomes","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041140/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38886167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}