{"title":"Durable Ventricular Assist Device for Bridge to Transplantation","authors":"M. Ono","doi":"10.5772/intechopen.102467","DOIUrl":"https://doi.org/10.5772/intechopen.102467","url":null,"abstract":"A durable ventricular assist device (VAD) is a key mechanical circulatory support to safely bridge a heart transplant candidate to transplantation over a long waiting period. Recent UNOS policy change has a great impact on the role of continuous-flow VAD as a bridging device. The rest of the majority of countries still rely on a cf-VAD as a safe and effective support device. A sole durable VAD for bridge to transplantation in pediatric patients is Berlin Heart EXCOR, for which there is a growing demand through the improvement of a long-term result. In this chapter, I will overview the history and the present status of durable VAD for bridge to transplantation in both adult and pediatric patients.","PeriodicalId":183542,"journal":{"name":"Heart Transplantation [Working Title]","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129708437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Primary Graft Dysfunction after Heart Transplantation","authors":"Soo Yong Lee","doi":"10.5772/intechopen.102506","DOIUrl":"https://doi.org/10.5772/intechopen.102506","url":null,"abstract":"The entire transplant journey that the donor heart experiences affect the donor heart function early after transplantation. The early graft dysfunction without discernible cause is primary graft dysfunction (PGD) and has been one of the critical complications and the cause of early mortality after orthotopic heart transplantation. Although, numerous researchers investigated the pathophysiology and the related biomarkers, the process is multifactorial and therefore no definite biomarker has been proposed. After the recent definition from the International Society of Heart and Lung Transplantation, the standard of management is still under investigation by each status. Here, the prevalence, pathophysiology, biomarkers, and recent progression of management of PGD will be reviewed.","PeriodicalId":183542,"journal":{"name":"Heart Transplantation [Working Title]","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117004956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Ikura, Kazuki Nakagita, T. Uno, Hiromi Takenaka, S. Matsuda, M. Yoshii, Rika Nagata, I. Nakakura, N. Hayakawa, Tsutomu Nakamura, K. Wada, O. Seguchi
{"title":"Role of the Transplant Pharmacist","authors":"M. Ikura, Kazuki Nakagita, T. Uno, Hiromi Takenaka, S. Matsuda, M. Yoshii, Rika Nagata, I. Nakakura, N. Hayakawa, Tsutomu Nakamura, K. Wada, O. Seguchi","doi":"10.5772/intechopen.102372","DOIUrl":"https://doi.org/10.5772/intechopen.102372","url":null,"abstract":"At the National Cerebral and Cardiovascular Center, Japan, pharmacists have been involved in drug treatment management and patient care as members of multidisciplinary heart transplant teams that include surgeons, physicians, recipient transplant coordinators, and nurses during the waiting period for heart transplantation (HTx), HTx surgery, and post-HTx. During the waiting period, pharmacists play an important role in adjusting the use of antibiotics, anticoagulants, and antiarrhythmics by patients receiving a ventricular assist device (VAD). During HTx surgery and post-HTx, pharmacists advise physicians regarding the individualized medication protocol for immunosuppression and infection prevention to be used for each patient based on the patient’s pre-HTx characteristics as well as gene polymorphisms. They thus contribute to reducing the burden on the physician through the sharing of tasks. Throughout all three phases of HTx, pharmacists repeatedly provide medication and adherence education to the patients and caregivers. It is hoped that an academic society-led training protocol as well as transplant pharmacists will be established in Japan and other developed countries, and that these specialized transplant pharmacists would then provide individualized pharmacotherapy for the use of various antibiotics, anticoagulants, and immunosuppressive agents that have a narrow range of treatment in VAD and HTx patients.","PeriodicalId":183542,"journal":{"name":"Heart Transplantation [Working Title]","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126857255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evolution of Heart Transplantation Surgical Techniques","authors":"S. Jacob, Anthony N. Pham, Si M. Pham","doi":"10.5772/intechopen.102512","DOIUrl":"https://doi.org/10.5772/intechopen.102512","url":null,"abstract":"Organ transplantation has kindled the human imagination since the beginning of time. Prehistorically, transplantation appeared as mythological stories: from creatures with body parts from different species, the heart transplant between two Chinese soldiers by Pien Ch’iao, to the leg transplant by physician Saints Cosmas and Damian. By 19th century, the transplantation concept become possible by extensive contributions from scientists and clinicians whose works had taken generations. Although Alexis Carrel is known as the founding father of experimental organ transplantation, many legendary names had contributed to the experimental works of heart transplantation, including Guthrie, Mann, and Demikhov. The major contribution to experimental heart transplantation before the clinical era were made by a team lead by Richard Lower and Norman Shumway at Stanford University in the early 1960s. They played the vital role in developing experimental and clinical heart transplantation as it is known today. Using Shumway biatrial technique Christiaan Barnard started a new era of clinical heart transplantation, by performing the first in man human-to-human heart transplantation in 1967. The techniques of heart transplant have evolved since the first heart transplant. This chapter will summarize the techniques that have been used in clinical heart transplantation.","PeriodicalId":183542,"journal":{"name":"Heart Transplantation [Working Title]","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131574974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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