Lead Chemistry最新文献

Epigenetics and Lead Neurotoxicity 表观遗传学和铅神经毒性

Lead Chemistry Pub Date : 2020-05-29 DOI: 10.5772/intechopen.92657

Yi Xu, Tian Wang, Jie Zhang

{"title":"Epigenetics and Lead Neurotoxicity","authors":"Yi Xu, Tian Wang, Jie Zhang","doi":"10.5772/intechopen.92657","DOIUrl":"https://doi.org/10.5772/intechopen.92657","url":null,"abstract":"Lead exposure continues to threaten human health in a worldwide perspective. Among the multiple target organs affected by lead, central nervous system (CNS) pervades in the adverse consequences by chronic lead exposure, leading to a variety of neurotoxic manifestations and neurological disorders. The epigenetic machinery plays a vital role in the control of key neural functions, particularly neuronal development. Faulty epigenetic gene regulation can have marked deleterious effect on the developing brain that can last for an entire lifespan. Mounting evidence suggests that lead exposure can pose detrimental effect on CNS through these epigenetic mechanisms. And this chapter reviews the current understandings of concrete epigenetic forms, exemplified by DNA methylation, histone modification, and ncRNAs, responding to lead exposure and moderating the consequent neurotoxicity. In addition, Alzheimer’s disease (AD) is presented as a typical instance to explain how environmental lead exposure results in the occurrence of AD in an “early exposure, late onset” fashion. A future perspective, highlighting additional forms of epigenetic elements as well as interactive actions among different molecules, was also proposed. In summary, epigenetics was substantially implicated in regulating lead neurotoxicity.","PeriodicalId":17958,"journal":{"name":"Lead Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76752179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Effects of Lead on Reproductive Health 铅对生殖健康的影响

Lead Chemistry Pub Date : 2020-04-15 DOI: 10.5772/intechopen.91992

Osmel La Llave León, José Manuel Salas Pacheco

引用次数: 10

High-Temperature Electrochemical Refining of Secondary Lead 二次铅的高温电化学精炼

Lead Chemistry Pub Date : 2020-03-09 DOI: 10.5772/intechopen.91429

Pavel A. Arkhipov, Yury P. Zaykov

{"title":"High-Temperature Electrochemical Refining of Secondary Lead","authors":"Pavel A. Arkhipov, Yury P. Zaykov","doi":"10.5772/intechopen.91429","DOIUrl":"https://doi.org/10.5772/intechopen.91429","url":null,"abstract":"The present chapter is devoted to the analysis of the obtained data on the high-temperature electrolytic production of high-purity lead from secondary lead in chloride melts. Kinetic parameters of electrode reactions were calculated, and the sequences of the metal dissolution from the double lead-antimony (Pb-Sb), lead-bismuth (Pb-Bi), and antimony-bismuth (Sb-Bi) alloys were determined. A long-term electrolysis of the antimony (battery scrap), bismuth (lead-bismuth), and lead-containing raw materials in the electrolytic cell of original construction with a porous ceramic diaphragm impregnated with the eutectic KCl-PbCl 2 chloride electrolyte was performed. The anode lead alloy, containing 57.0 wt% of antimony and 36.0 wt% of bismuth, and cathode grade lead were obtained as a result of the electrolysis. The values of lead, antimony, and bismuth separation coefficients were calculated according to the values of the equilibrium potentials of the Pb-Sb, Pb-Bi, and Sb-Bi alloys. The values of separation coefficients were found to be 6.5 (cid:1) 10 6 – 1.5 (cid:1) 10 8 for a single stage at the lead extraction from the Pb-Sb and Pb-Bi alloys, which proves the possibility of a highly effective lead extraction. The value of Sb-Bi alloy separation coefficient ranges from 5.5 to 6.5, which testifies the complexity and low effectiveness of the separation process. An electrolytic refining of lead-bismuth and secondary lead, obtained from the battery scrap, was performed.","PeriodicalId":17958,"journal":{"name":"Lead Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85608771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis, Characterization, Applications, and Toxicity of Lead Oxide Nanoparticles 氧化铅纳米颗粒的合成、表征、应用及毒性研究

Lead Chemistry Pub Date : 2020-02-21 DOI: 10.5772/intechopen.91362

Amra Bratovcic

{"title":"Synthesis, Characterization, Applications, and Toxicity of Lead Oxide Nanoparticles","authors":"Amra Bratovcic","doi":"10.5772/intechopen.91362","DOIUrl":"https://doi.org/10.5772/intechopen.91362","url":null,"abstract":"Over the past few years, the interest of material scientists for metal and metal oxide nanoparticles (NPs) is increasing dramatically because of their unique physicochemical characteristics such as catalytic activity and optical, electronic, antibacterial, and magnetic properties which depend on their size, shape, and chemical surroundings. Recently, several new routes of synthesis of lead monoxide (PbO) nanoparticles have been used, such as chemical synthesis, calcination, sol-gel pyrolysis, anodic oxidation, solvothermal method, thermal decomposition, chemical deposition, laser ablation, and green methods. Essentially, for the structural characterization of lead oxide nanoparticles, several spectroscopic, microscopic, and thermogravimetric methods of analysis are used. Lead oxide has been widely utilized in batteries, gas sensors, pigments, ceramics, and glass industry. Furthermore, lead oxide nanoparticles are graded as toxic and dangerous for the human health and environment. Therefore, there is an urgent need to develop new approaches and standardized test procedures to study the potential hazardous effect of nanoparticles on the human health and environment. The aim of this chapter is to provide an overview of the recent trends in synthesis of lead oxide nanoparticles, their characterization, possible applications, and toxicity.","PeriodicalId":17958,"journal":{"name":"Lead Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87973144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22