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Update on Mesenchymal and Induced Pluripotent Stem Cells最新文献

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The Rising Role of Mesenchymal Stem Cells in the Treatment of Various Infectious Complications 间充质干细胞在治疗各种感染性并发症中的作用日益增强
Update on Mesenchymal and Induced Pluripotent Stem Cells Pub Date : 2020-03-10 DOI: 10.5772/INTECHOPEN.91475
K. Al-Anazi, Waleed Khalid Al-Anazi, A. M. Al-Jasser
{"title":"The Rising Role of Mesenchymal Stem Cells in the Treatment of Various Infectious Complications","authors":"K. Al-Anazi, Waleed Khalid Al-Anazi, A. M. Al-Jasser","doi":"10.5772/INTECHOPEN.91475","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.91475","url":null,"abstract":"Mesenchymal stem cells are heterogenous adult multipotent stromal cells that can be isolated from various sources including: bone marrow, peripheral blood, umbilical cord blood, dental pulp, and adipose tissue. They have certain immunomodulatory, immunosuppressive, and antimicrobial properties that enable them to have several therapeutic and clinical applications including: treatment of autoimmune disorders, role in hematopoietic stem cell transplantation and regenerative medicine, as well as treatment of various infections and their associated complications such as septic shock and acute respiratory distress syndrome. Although more success has been achieved in preclinical trials on the use of mesenchymal stem cells in animal models than in human clinical trials, particularly in septic shock and Chagas disease, more progress has been made in both disorders after the recent use of specific sources and certain doses of mesenchymal stem cells. Nevertheless, the utilization of this type of stem cells has shown remarkable progress in the treatment of few infections such as tuberculosis. The clinical application of mesenchymal stem cells in the treatment of several diseases still faces real challenges that need to be resolved. The following book chapter will be an updated review on the role of mesenchymal stem cells in various infections and their complications.","PeriodicalId":179473,"journal":{"name":"Update on Mesenchymal and Induced Pluripotent Stem Cells","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128449781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Introductory Chapter: Update on Mesenchymal and Induced Pluripotent Stem Cells 导论:间充质干细胞和诱导多能干细胞的最新进展
Update on Mesenchymal and Induced Pluripotent Stem Cells Pub Date : 2020-02-06 DOI: 10.5772/intechopen.90236
K. Al-Anazi
{"title":"Introductory Chapter: Update on Mesenchymal and Induced Pluripotent Stem Cells","authors":"K. Al-Anazi","doi":"10.5772/intechopen.90236","DOIUrl":"https://doi.org/10.5772/intechopen.90236","url":null,"abstract":"Stem cells are a subset of biological cells in the human body that are capable of self-renewal, tissue repair, differentiation, and division into different cell lineages [1–3]. Based on their origin and potency, stem cells are divided into either (1) embryonic and adult (non-embryonic) stem cells or (2) unipotent, oligopotent, totipotent, multipotent, and pluripotent stem cells [1, 2, 4, 5]. Multipotent or adult stem cells include mesenchymal stem cells (MSCs), while pluripotent stem cells include embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) [5].","PeriodicalId":179473,"journal":{"name":"Update on Mesenchymal and Induced Pluripotent Stem Cells","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114609580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
The Angiogenic Paracrine Potential of Mesenchymal Stem Cells 间充质干细胞血管生成旁分泌电位
Update on Mesenchymal and Induced Pluripotent Stem Cells Pub Date : 2019-09-23 DOI: 10.5772/intechopen.84433
J. Rezaie, Morteza Heidarzadeh, M. Hassanpour, Hassan Amini, Elhameh Shokrollahi, M. Ahmadi, R. Rahbarghazi
{"title":"The Angiogenic Paracrine Potential of Mesenchymal Stem Cells","authors":"J. Rezaie, Morteza Heidarzadeh, M. Hassanpour, Hassan Amini, Elhameh Shokrollahi, M. Ahmadi, R. Rahbarghazi","doi":"10.5772/intechopen.84433","DOIUrl":"https://doi.org/10.5772/intechopen.84433","url":null,"abstract":"Tissue engineering and regenerative medicine are branches of biomedical sciences that facilitate the use of cells and biocompatible scaffolds in favor of tissue restoration. In this regard, restoration and maintenance of angiogenesis and blood supplementation could be an effective strategy for injured tissue removal, accelerating healing rate, and successful transplantation of cells and scaffolds into target sites. It has been elucidated that mesenchymal stem cells have the potency to promote angiogenesis via paracrine activity and trans-differentiation into the endothelial lineage. In this chapter, we highlighted the paracrine property of mesenchymal stem cells to modulate angiogenesis in the target tissues. family proteins regulate intercellular trafficking and docking of MVBs. In the secretory pathway, MVBs actively fuse with the plasma membrane to release exosomes into the extracellular space. In alternative pathways, MVB could prefer binding to the lysosome or directly fuse back to the plasma membrane. Once secreted, exosomes enroll several mechanisms to arrive at the target cell: (I) enter through internalization process; (II) bind through receptor-ligand interactions, (III) direct fusion with the plasma membrane of the target cell. Exosomes are able to affect the biological processes of the target cells.","PeriodicalId":179473,"journal":{"name":"Update on Mesenchymal and Induced Pluripotent Stem Cells","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114350590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Induced Pluripotent Stem Cells for Clinical Use 临床应用的诱导多能干细胞
Update on Mesenchymal and Induced Pluripotent Stem Cells Pub Date : 2019-09-06 DOI: 10.5772/intechopen.88878
V. Vanneaux
{"title":"Induced Pluripotent Stem Cells for Clinical Use","authors":"V. Vanneaux","doi":"10.5772/intechopen.88878","DOIUrl":"https://doi.org/10.5772/intechopen.88878","url":null,"abstract":"","PeriodicalId":179473,"journal":{"name":"Update on Mesenchymal and Induced Pluripotent Stem Cells","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132624655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
GMSC: Updates of Advances on Its Therapy in Immunological Diseases GMSC:其在免疫疾病治疗中的最新进展
Update on Mesenchymal and Induced Pluripotent Stem Cells Pub Date : 2019-07-09 DOI: 10.5772/INTECHOPEN.85153
Yuluan Hou, S. Zheng
{"title":"GMSC: Updates of Advances on Its Therapy in Immunological Diseases","authors":"Yuluan Hou, S. Zheng","doi":"10.5772/INTECHOPEN.85153","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.85153","url":null,"abstract":"Mesenchymal stem cells (MSCs) derived from various tissues are multi-potency of self-renewal and differentiation into multi-lineages, including chondrocytes, adipocytes and osteoblasts in vitro and in vivo . In addition, these cells also display potent immune regulatory roles that benefit the treatment of inflammatory and autoimmune diseases. We and others have previously identified that human gingival-derived mesenchymal stem cells (GMSCs) not only share similar biological features, but also display some potential advantages compared to other MSC populations. In the chapter, we have discussed the discovery, phenotypic and func-tional characteristics, as well as updated the advances of these cell therapies in immunological diseases.","PeriodicalId":179473,"journal":{"name":"Update on Mesenchymal and Induced Pluripotent Stem Cells","volume":"27 7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125688404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Mesenchymal Stromal Cells in the Management of Osteoarthritis of the Knee 间充质间质细胞在膝关节骨关节炎治疗中的作用
Update on Mesenchymal and Induced Pluripotent Stem Cells Pub Date : 2019-05-21 DOI: 10.5772/INTECHOPEN.86016
Charan Thej, Pawan Kumar Gupta
{"title":"The Role of Mesenchymal Stromal Cells in the Management of Osteoarthritis of the Knee","authors":"Charan Thej, Pawan Kumar Gupta","doi":"10.5772/INTECHOPEN.86016","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.86016","url":null,"abstract":"Osteoarthritis (OA) is one of the most common chronic, inflammatory, and degenerative diseases affecting the synovial joints, the hip, and the knee. OA is commonly managed clinically by treating pain with anti-inflammatory medicines using nonsteroidal anti-inflammatory drugs (NSAIDS) or analgesics. In severe OA patients, invasive knee replacement surgery is the last option. Treatment of OA using mesenchymal stromal cells (MSCs) has been widely explored due to their anti-inflammatory properties and chondrogenic differentiation potential. In this chapter, we comprehensively discuss in detail the in vitro OA potency development, OA preclinical studies, and clinical trials conducted using MSCs.","PeriodicalId":179473,"journal":{"name":"Update on Mesenchymal and Induced Pluripotent Stem Cells","volume":"74 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130681635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
The Dual Nature of Mesenchymal Stem Cells (MSCs): Yin and Yang of the Inflammatory Process 间充质干细胞(MSCs)的双重性质:炎症过程的阴阳
Update on Mesenchymal and Induced Pluripotent Stem Cells Pub Date : 2019-03-15 DOI: 10.5772/INTECHOPEN.82877
C. Ciavarella, G. Pasquinelli
{"title":"The Dual Nature of Mesenchymal Stem Cells (MSCs): Yin and Yang of the Inflammatory Process","authors":"C. Ciavarella, G. Pasquinelli","doi":"10.5772/INTECHOPEN.82877","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.82877","url":null,"abstract":"The well-known reparative properties of mesenchymal stem cells (MSCs) make them an attractive source for cell-based therapy. In vitro and in vivo studies support an anti-inflammatory role of MSCs by directly targeting immune cells or via the secretion of immunomodulatory factors. MSCs have been isolated from several human normal tissues, even from pathological biopsies and blood samples; in these cases, MSCs displayed peculiar characteristics, suggesting a phenotype transition into a pathological state. Indeed, MSCs derived from inflamed tissues acquired a pro-inflammatory behaviour. In this view, MSCs may be crucial players of many pathways involved in human diseases, especially during the inflammatory cascade. The present chapter will minutely describe the basic biology of human MSCs derived from normal and pathological arteries, focusing on their dual nature as cellular switchers of the inflammatory setting. We will also discuss the emerging role of miRNAs in regulating MSC functions and their potential use as alternative strategies to manipulate MSC efficacy.","PeriodicalId":179473,"journal":{"name":"Update on Mesenchymal and Induced Pluripotent Stem Cells","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128989326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
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